INT100952

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Context Info
Confidence 0.35
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.34
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NAT2) small molecule metabolic process (NAT2) transferase activity, transferring acyl groups (NAT2)
cytoplasm (NAT2)
Anatomy Link Frequency
T24 2
NAT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 6 96.00 Very High Very High Very High
cINOD 1 95.24 Very High Very High Very High
Paracetamol 5 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bladder Cancer 10 97.80 Very High Very High Very High
INFLAMMATION 1 95.04 Very High Very High Very High
Toxicity 3 62.96 Quite High
Nicotine Addiction 11 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Transitional Cell Carcinoma 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Adenoma 2 5.00 Very Low Very Low Very Low
Nephrotoxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In two cell lines both deficient in NER and one expressing CYP1A2 and NAT2, 2,6-DMA and 3,5-DMA were cytotoxic at dose levels of 100 ?
Negative_regulation (deficient) of Gene_expression (one) of NAT2
1) Confidence 0.35 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0.06 Pain Relevance 0.08
Sulindac inhibited gene expression and activity of arylamine N-acetyltransferase and DNA-2-aminofluorene adduct formation in T24 human bladder tumor cells.
Negative_regulation (inhibited) of Gene_expression (expression) of arylamine N-acetyltransferase in T24 associated with bladder cancer
2) Confidence 0.27 Published 2001 Journal Urol. Res. Section Title Doc Link 11828994 Disease Relevance 0.28 Pain Relevance 0.10

General Comments

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