INT100965

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 85
Total Number 86
Disease Relevance 37.74
Pain Relevance 75.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 11
nerve 7
cortex 4
sciatic nerve 4
sensory neurons 3
Nav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nav1.6 1382 100.00 Very High Very High Very High
sodium channel 1008 100.00 Very High Very High Very High
Sciatic nerve 962 100.00 Very High Very High Very High
nav1.8 935 100.00 Very High Very High Very High
nav1.3 390 100.00 Very High Very High Very High
Nav1.2 272 100.00 Very High Very High Very High
Nav1.1 100 100.00 Very High Very High Very High
addiction 71 100.00 Very High Very High Very High
Nav1.7 58 100.00 Very High Very High Very High
nociceptor 55 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1376 99.84 Very High Very High Very High
Nerve Compression Syndromes 496 99.84 Very High Very High Very High
Injury 1437 99.72 Very High Very High Very High
Nociception 237 99.60 Very High Very High Very High
Inflammatory Pain 36 98.92 Very High Very High Very High
Pain 477 98.12 Very High Very High Very High
Hypersensitivity 81 98.00 Very High Very High Very High
Nervous System Injury 353 97.96 Very High Very High Very High
Hypertrophy 18 97.96 Very High Very High Very High
Neuropathic Pain 546 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein levels for Nav1.1 and Nav1.6 were up-regulated in layer II-IV cortical neurons in this region of cortex.
Positive_regulation (up-regulated) of Nav1 in cortex associated with nav1.1 and nav1.6
1) Confidence 0.70 Published 2004 Journal Brain Res. Section Abstract Doc Link 15053958 Disease Relevance 0.29 Pain Relevance 0.92
SWDs increased with age in WAG/Rij rats. mRNA levels for sodium channels Nav1.1 and Nav1.6, but not Nav1.2, were found to be up-regulated selectively within the facial somatosensory cortex (at AP +0.0, ML +6.0 mm).
Positive_regulation (up-regulated) of Nav1 in cortex associated with somatosensory cortex, nav1.1, nav1.2, sodium channel and nav1.6
2) Confidence 0.70 Published 2004 Journal Brain Res. Section Abstract Doc Link 15053958 Disease Relevance 0.23 Pain Relevance 0.80
Protein levels for Nav1.1 and Nav1.6 were up-regulated in layer II-IV cortical neurons in this region of cortex.
Positive_regulation (up-regulated) of Nav1 in cortex associated with nav1.1 and nav1.6
3) Confidence 0.70 Published 2004 Journal Brain Res. Section Abstract Doc Link 15053958 Disease Relevance 0.29 Pain Relevance 0.92
This could be related to the relatively few number of projections from the lumbar spinal cord, or low levels of Nav1.3 transcript upregulation after CCI.
Positive_regulation (upregulation) of Nav1 in spinal cord associated with nav1.3, eae and spinal cord
4) Confidence 0.70 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 1.00 Pain Relevance 1.46
Typical nodes were identified and defined by the presence of a dense Nav1.6 accumulation flanked on both sides by the paranodal staining of caspr as seen in the Nav1.6 combined with caspr z-series.
Positive_regulation (accumulation) of Nav1.6 in nodes associated with nav1.6
5) Confidence 0.69 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.81
The Nav1.6 accumulation was traced with the "freehand" tool and a histogram was generated to collect the number of pixels, average intensity, and standard deviation values for that accumulation.
Positive_regulation (accumulation) of Nav1.6 associated with nav1.6
6) Confidence 0.69 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.64
The common relationship of caspr with Nav1.6 was also altered in some accumulations and included the presence of "heminodes" where caspr staining was located on only one side of a contiguous Nav1.6 accumulation and "split nodes" where two distinct NaCh accumulations were separated by a gap in the same fiber and with each accumulation flanked on one side by caspr (Fig. 2B).
Positive_regulation (accumulation) of Nav1.6 in nodes associated with sodium channel and nav1.6
7) Confidence 0.69 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.78
This step allowed an objective method of distinguishing pixels within the Nav1.6 accumulation that were included in the evaluation, without altering intensity values.
Positive_regulation (accumulation) of Nav1.6 associated with nav1.6
8) Confidence 0.69 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.72
Since the apparent density, size (including the nodal gap axial length) and intensity of Nav1.6 accumulations, and the intensity of caspr staining in the paranodal region of typical nodes appeared so different in lesioned IONs when compared to normal IONs, these observations were evaluated further using quantitative techniques.


Positive_regulation (accumulations) of Nav1.6 in nodes associated with nav1.6
9) Confidence 0.69 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.81
Quantitative evaluation determined that the density (Fig. 3A) and size (Fig. 3B) of Nav1.6 accumulations were both significantly greater in the lesioned IONs when compared to normal IONs.
Positive_regulation (accumulations) of Nav1.6 associated with nav1.6
10) Confidence 0.69 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.80
Four weeks after injury when extracellular recordings demonstrated hyperexcitability of L3-L5 dorsal horn multireceptive nociceptive neurons, and when pain-related behaviors were evident, quantitative RT-PCR, in situ hybridization, and immunocytochemistry revealed an upregulation of Nav1.3 in dorsal horn nociceptive neurons.
Positive_regulation (upregulation) of Nav1 in neurons associated with nociception, nav1.3, pain, injury, dorsal horn and hyperexcitability
11) Confidence 0.69 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14523090 Disease Relevance 1.54 Pain Relevance 1.85
These results demonstrate for the first time that Nav1.3 is upregulated in second-order dorsal horn sensory neurons after nervous system injury, showing that SCI can trigger changes in sodium channel expression, and suggest a functional link between Nav1.3 expression and neuronal hyperexcitability associated with central neuropathic pain.
Positive_regulation (upregulated) of Nav1 in nervous system associated with nav1.3, nervous system injury, frailty, neuropathic pain, sodium channel, dorsal horn and hyperexcitability
12) Confidence 0.69 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14523090 Disease Relevance 1.43 Pain Relevance 1.92
The increased persistent sodium current and ramp current, which are consistent with upregulation of Nav1.3 within dorsal horn neurons, suggest a basis for the hyperresponsiveness of these neurons following SCI.
Positive_regulation (upregulation) of Nav1 in neurons associated with nav1.3, spinal cord injury and dorsal horn neuron
13) Confidence 0.69 Published 2006 Journal Exp Brain Res Section Abstract Doc Link 16718433 Disease Relevance 0.79 Pain Relevance 0.49
Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury.
Positive_regulation (Upregulation) of Nav1 in neuronal associated with nav1.3, neuralgia, neuropathic pain, sodium channel, hyperexcitability and spinal cord
14) Confidence 0.60 Published 2003 Journal J. Neurosci. Section Title Doc Link 14523090 Disease Relevance 1.29 Pain Relevance 1.85
Nav1.7, Nav1.6 and Nav1.3 channels are upregulated [36-39] or down-regulated [25,39-41] in DRG neurons after nerve injury or axotomy.
Positive_regulation (upregulated) of Nav1 in nerve associated with dorsal root ganglion, nav1.3, nervous system injury, nav1.6 and nav1.7
15) Confidence 0.55 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 0.96 Pain Relevance 1.51
Nav1.7, Nav1.6 and Nav1.3 channels are upregulated [36-39] or down-regulated [25,39-41] in DRG neurons after nerve injury or axotomy.
Positive_regulation (upregulated) of Nav1 in nerve associated with dorsal root ganglion, nav1.3, nervous system injury, nav1.6 and nav1.7
16) Confidence 0.55 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 0.97 Pain Relevance 1.52
Nav1.7, Nav1.6 and Nav1.3 channels are upregulated [36-39] or down-regulated [25,39-41] in DRG neurons after nerve injury or axotomy.
Positive_regulation (upregulated) of Nav1 in nerve associated with dorsal root ganglion, nav1.3, nervous system injury, nav1.6 and nav1.7
17) Confidence 0.55 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 0.97 Pain Relevance 1.52
Therefore, intra-axonal polyadenylation resulting in reduced turnover and increased steady-state mRNA levels [45] was ruled out as a mechanism of increased NaV1.8 mRNA accumulation in SNE axons.
Positive_regulation (accumulation) of NaV1 associated with nerve compression syndromes
18) Confidence 0.53 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.49 Pain Relevance 0.23
Another possibility we considered was the upregulation of a third TTX-R channel, Nav1.5, which is normally expressed in sensory neurons during development but declines to very low levels at birth and adulthood [36].
Positive_regulation (upregulation) of Nav1 in sensory neurons
19) Confidence 0.53 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.55 Pain Relevance 0.53
SWDs increased with age in WAG/Rij rats. mRNA levels for sodium channels Nav1.1 and Nav1.6, but not Nav1.2, were found to be up-regulated selectively within the facial somatosensory cortex (at AP +0.0, ML +6.0 mm).
Positive_regulation (up-regulated) of Nav1 in cortex associated with somatosensory cortex, nav1.1, nav1.2, sodium channel and nav1.6
20) Confidence 0.50 Published 2004 Journal Brain Res. Section Abstract Doc Link 15053958 Disease Relevance 0.23 Pain Relevance 0.80

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