INT101

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Context Info
Confidence 0.57
First Reported 1976
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 3.48
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (HRH1) plasma membrane (HRH1) nucleus (HRH1)
cytoplasm (HRH1) signal transducer activity (HRH1)
Anatomy Link Frequency
plasma 1
basophils 1
HRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 25 100.00 Very High Very High Very High
Antihistamine 25 99.80 Very High Very High Very High
Migraine 6 99.68 Very High Very High Very High
tetrodotoxin 1 99.20 Very High Very High Very High
headache 11 98.16 Very High Very High Very High
c fibre 1 90.88 High High
neuropeptide release 1 90.00 High High
Inflammatory mediators 2 88.40 High High
Inflammation 27 88.24 High High
Neuropeptide 3 87.80 High High
Disease Link Frequency Relevance Heat
Migraine Disorders 8 99.68 Very High Very High Very High
Headache 10 98.16 Very High Very High Very High
Necrosis 2 95.80 Very High Very High Very High
Wheal 4 95.56 Very High Very High Very High
Cancer 2 95.44 Very High Very High Very High
Weight Gain 2 94.92 High High
INFLAMMATION 53 88.24 High High
Increased Venous Pressure Under Development 7 87.44 High High
Insulin Resistance 2 86.08 High High
Asthma 10 82.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to blocking the H1-receptor, an antihistamine may have other effects that contribute to its antiallergic effect.
Negative_regulation (blocking) of H1-receptor associated with antihistamine
1) Confidence 0.57 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC3003605 Disease Relevance 0.86 Pain Relevance 0.21
These results indicate that histamine H1 receptor antagonists such as mepyramine are potent inhibitors of P450 2D forms because of their high affinity for these enzymes.
Negative_regulation (inhibitors) of histamine H1 receptor associated with antagonist
2) Confidence 0.36 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7853212 Disease Relevance 0 Pain Relevance 0.23
It is also postulated that central blockade of the H1 receptor and 5-HT2c receptor stimulates energy intake by increasing appetite with a resultant positive energy balance, thereby causing weight gain [23–25].
Spec (postulated) Negative_regulation (blockade) of H1 receptor associated with weight gain
3) Confidence 0.32 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2668653 Disease Relevance 0.70 Pain Relevance 0.27
Because both immediate histamine-induced headache and intracranial arterial dilatation and delayed histamine-induced migraine are blocked by H1-receptor blockade, a likely common pathway for GTN and histamine-induced headaches/migraines and intracranial arterial responses may be via activation of the NO-cGMP pathway.
Spec (likely) Negative_regulation (blockade) of H1-receptor associated with migraine, migraine disorders and headache
4) Confidence 0.28 Published 1997 Journal Cephalalgia Section Abstract Doc Link 9453277 Disease Relevance 1.20 Pain Relevance 1.02
The activation induced by IBS supernatants was inhibited by histamine receptor (H1-H3) antagonists, 5-HT3 receptor antagonist, and protease inhibition.
Negative_regulation (antagonists) of histamine receptor
5) Confidence 0.18 Published 2009 Journal Gastroenterology Section Body Doc Link 19596012 Disease Relevance 0 Pain Relevance 0
The administration of Famotidine was repeated 12 hours after the first dose to ensure an adequate plasma level of the drug and continuous histamine receptor blockade.
Negative_regulation (blockade) of histamine receptor in plasma
6) Confidence 0.08 Published 2007 Journal J Transl Med Section Body Doc Link PMC1929055 Disease Relevance 0 Pain Relevance 0.24
Histamine receptor antagonists reduced by approximately 60% UVB and cis-UCA-induced systemic immunosuppression.
Negative_regulation (reduced) of Histamine receptor associated with antagonist
7) Confidence 0.05 Published 2002 Journal Methods Section Abstract Doc Link 12231191 Disease Relevance 0.25 Pain Relevance 0.40
The vasodilator response to 5-HT is unaffected by alpha- or beta-adrenergic or cholinergic receptor blockade, by ganglionic blockade, or by histamine receptor blockade, but is blocked by tetrodotoxin and also the 5-HT antagonist, dihydroergotamine.
Negative_regulation (blockade) of histamine receptor associated with tetrodotoxin and antagonist
8) Confidence 0.03 Published 1976 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 9034 Disease Relevance 0.41 Pain Relevance 0.18
For example, rat mast cells have been shown to produce an "NO-like factor" which inhibits histamine-release [32] while there are investigations that indicate that NO does not affect histamine-secretion in human basophils [33].
Negative_regulation (inhibits) of histamine-release in basophils
9) Confidence 0.00 Published 2004 Journal BMC Gastroenterol Section Body Doc Link PMC514546 Disease Relevance 0 Pain Relevance 0
NO can inhibit this histamine-release [14] and thereby further contribute to the inhibition of acid secretion.
Negative_regulation (inhibit) of histamine-release
10) Confidence 0.00 Published 2004 Journal BMC Gastroenterol Section Body Doc Link PMC514546 Disease Relevance 0 Pain Relevance 0

General Comments

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