INT10100

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Context Info
Confidence 0.47
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 22
Total Number 32
Disease Relevance 15.32
Pain Relevance 5.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)
Anatomy Link Frequency
chondrocytes 7
PMN 5
cleavage 2
brain 1
fibroblast 1
ELANE (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 504 100.00 Very High Very High Very High
metalloproteinase 128 100.00 Very High Very High Very High
anesthesia 6 99.80 Very High Very High Very High
diclofenac 12 99.62 Very High Very High Very High
Opioid 4 99.58 Very High Very High Very High
Inflammation 279 99.42 Very High Very High Very High
cytokine 100 98.16 Very High Very High Very High
potassium channel 4 95.08 Very High Very High Very High
narcan 2 93.60 High High
antagonist 6 93.24 High High
Disease Link Frequency Relevance Heat
Osteoarthritis 439 100.00 Very High Very High Very High
INFLAMMATION 358 99.42 Very High Very High Very High
Toxicity 18 99.08 Very High Very High Very High
Adhesions 289 98.96 Very High Very High Very High
Reprotox - General 3 10 98.84 Very High Very High Very High
Pressure And Volume Under Development 13 98.00 Very High Very High Very High
Colon Cancer 12 97.40 Very High Very High Very High
Necrosis 57 96.80 Very High Very High Very High
Cancer 76 96.44 Very High Very High Very High
Stress 435 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The physiological significance of vasopressin in this region is unclear; however, it is possible that vasopressin in SCN influences the circadian rhythm of other brain peptides via synaptic interaction, as a pacemaker.
SCN Binding (interaction) of in brain
1) Confidence 0.47 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0
Incorporation of silver into alginate fibers increased antimicrobial activity and improved the binding affinity for elastase, matrix metalloproteases-2, and the proinflammatory cytokines tested.
elastase Binding (affinity) of associated with cytokine
2) Confidence 0.42 Published 2009 Journal Wound Repair Regen Section Abstract Doc Link 19614916 Disease Relevance 0.99 Pain Relevance 0.19
Alginate was found to bind considerable amounts of elastase, reduce the concentration of proinflammatory cytokines and inhibit the formation of free radicals.
elastase Binding (bind) of associated with cytokine
3) Confidence 0.42 Published 2009 Journal Wound Repair Regen Section Abstract Doc Link 19614916 Disease Relevance 1.20 Pain Relevance 0.23
In the experiment in which pancreatic juice and pig pancreatic kallikrein were added to granulocytes in vitro, we recognized a gradual release of PMN-elastase.
PMN-elastase Binding (recognized) of in PMN
4) Confidence 0.34 Published 1992 Journal Agents Actions Suppl. Section Abstract Doc Link 1462874 Disease Relevance 0.42 Pain Relevance 0.08
Incorporation of silver into alginate fibers increased antimicrobial activity and improved the binding affinity for elastase, matrix metalloproteases-2, and the proinflammatory cytokines tested.
elastase Binding (binding) of associated with cytokine
5) Confidence 0.32 Published 2009 Journal Wound Repair Regen Section Abstract Doc Link 19614916 Disease Relevance 0.99 Pain Relevance 0.19
On immune-precipitation of neutrophil elastase in BALF, CS was detected in the immune precipitate, which indicates a possible association of CS with neutrophil elastase in BALF.
elastase Binding (immune-precipitation) of in neutrophil
6) Confidence 0.32 Published 2006 Journal Transl Res Section Abstract Doc Link 16890150 Disease Relevance 0.20 Pain Relevance 0.45
By binding to proteins, HNE activates MMP-13 and increases the susceptibility of type II collagen to proteolytic cleavage by MMP-13 [18].
HNE Binding (binding) of in cleavage associated with metalloproteinase
7) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.64 Pain Relevance 0.39
Diclofenac was also shown to bind to PMN with a low affinity.
PMN Binding (bind) of in PMN associated with diclofenac
8) Confidence 0.14 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3300657 Disease Relevance 0 Pain Relevance 0.38
Judging from our experience with HNE, cellular responses to electrophiles appear to be graduated based upon concentration and time of exposure.
HNE Binding (experience) of
9) Confidence 0.12 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.38 Pain Relevance 0
By binding to proteins, HNE is capable of activating MMP-13 and increasing the susceptibility of type II collagen (Col II) to proteolytic cleavage by MMP-13 [10].
HNE Binding (binding) of in cleavage
10) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.73 Pain Relevance 0.29
Taken together, these findings suggest that interactions between chondrocytes and HNE-modified Col II may contribute to the production of inflammatory and catabolic mediators known to be involved in OA.


HNE-modified Binding (interactions) of in chondrocytes associated with inflammation and osteoarthritis
11) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.33 Pain Relevance 0.17
These data indicate that interactions between human OA chondrocytes and HNE-Coll II adduct influence cell morphology, viability and phenotype.
HNE-Coll Binding (interactions) of in chondrocytes associated with osteoarthritis
12) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.10 Pain Relevance 0.05
Binding of opioid peptides to the formyl peptide receptor was ruled out as a mechanism of increased adherence by showing that the opioids failed to block the binding of f-met-leu-phe-lys to PMN.
PMN Binding (binding) of in PMN associated with opioid
13) Confidence 0.09 Published 1987 Journal J. Neuroimmunol. Section Abstract Doc Link 2954999 Disease Relevance 0.07 Pain Relevance 0.89
To gain insights into the signalling pathways activated during interactions between chondrocytes and HNE-modified Col II, we examined the HNE-induced phosphorylation patterns of MAPKs over extended time periods by Western blotting and ELISA.
HNE-modified Binding (interactions) of in chondrocytes
14) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.30 Pain Relevance 0.15
In the next series of experiments, we investigated whether interactions between chondrocytes and their surrounding matrix, HNE-modified Col II, regulate the production of factors known to be involved in OA, such as PGE2, a product of COX-2, and MMP-13.
HNE-modified Binding (interactions) of in chondrocytes associated with osteoarthritis
15) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.19 Pain Relevance 0.10
time, the interaction between the major lipoperoxidation product, HNE, and PPAR
HNE Binding (interaction) of
16) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.74 Pain Relevance 0.07
Our results clearly showed that interactions between chondrocytes and HNE-Col II adducts, probably via adhesion molecules, strongly evoking a panoply of signalling pathways that trigger cell adhesion and viability as well as MMP-13 and COX-2 expression, as illustrated in Figure 7.
HNE-Col Binding (interactions) of in chondrocytes associated with adhesions
17) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.74 Pain Relevance 0.10
Therefore, it has the ability to displace bound HNE off the protein surface or to bind covalently into HNE-protein adducts.
HNE-protein Binding (bind) of
18) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.47 Pain Relevance 0.15
Our novel findings indicate that HNE-binding to Col II results in multiple abnormalities of chondrocyte phenotype and function, suggesting its contribution in osteoarthritis development.
HNE Binding (-) of in chondrocyte associated with reprotox - general 3 and osteoarthritis
19) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991038 Disease Relevance 0.62 Pain Relevance 0.09
The main purpose of this study was to investigate interactions between human OA chondrocytes and HNE-modified Col II.
HNE-modified Binding (interactions) of in chondrocytes associated with osteoarthritis
20) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.17 Pain Relevance 0.05

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