INT10101

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Context Info
Confidence 0.36
First Reported 1988
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 12.62
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PLAT) protein modification process (PLAT) extracellular space (PLAT)
extracellular region (PLAT) cytoplasm (PLAT)
Anatomy Link Frequency
chorion 1
blood 1
coronary artery 1
amnion 1
BC-1 1
PLAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Percutaneous transluminal coronary angioplasty 16 99.92 Very High Very High Very High
Inflammatory response 17 99.60 Very High Very High Very High
Angina 39 98.16 Very High Very High Very High
ischemia 44 97.24 Very High Very High Very High
cva 89 94.84 High High
cytokine 63 94.44 High High
metalloproteinase 12 92.88 High High
tetrodotoxin 1 92.72 High High
Inflammatory marker 11 83.36 Quite High
Inflammation 82 82.96 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 148 100.00 Very High Very High Very High
Coronary Artery Disease 124 100.00 Very High Very High Very High
Death 69 100.00 Very High Very High Very High
INFLAMMATION 109 99.60 Very High Very High Very High
Shock 2 99.54 Very High Very High Very High
Head Trauma 3 98.88 Very High Very High Very High
Cv General 3 Under Development 86 98.16 Very High Very High Very High
Rupture 29 98.08 Very High Very High Very High
Stress 39 98.00 Very High Very High Very High
Hemorrhage 39 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many prospective studies have shown independent associations between CHD events (MI and CHD death) and C-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen, von Willebrand factor (VWF), fibrin D-dimer and tissue plasminogen activator antigen (t-PA) in both middle-aged and older populations [2–13].
t-PA Neg (independent) Binding (associations) of associated with coronary artery disease, death and myocardial infarction
1) Confidence 0.36 Published 2009 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2810437 Disease Relevance 3.10 Pain Relevance 0.42
CONCLUSION: In prehospital thrombolysis, double bolus reteplase is associated with a shorter time to treatment than bolus anistreplase or infusion of streptokinase.


reteplase Binding (associated) of
2) Confidence 0.36 Published 2003 Journal Am. Heart J. Section Body Doc Link 12947366 Disease Relevance 0.06 Pain Relevance 0
Furthermore, in shock conditions, levels of t-PA inhibition were high in both the non-leukopenic and leukopenic groups [27].
t-PA Neg (inhibition) Binding (inhibition) of associated with shock
3) Confidence 0.35 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC117121 Disease Relevance 0.74 Pain Relevance 0
m) while combination of t-PA with abiciximab and eptifibatide determined no alteration in capillary perfusion compared with the baseline (9980 ± 350 ?
t-PA Spec (determined) Binding (combination) of in capillary
4) Confidence 0.35 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC117121 Disease Relevance 0.31 Pain Relevance 0.04
Our association with tPA seen in maternal samples supports previous findings observing elevated levels of tPA in maternally derived decidua, but not in fetally derived amnion/chorion tissues [34], [35].
tPA Binding (association) of in chorion
5) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.28 Pain Relevance 0.06
Thrombolysis with recombinant human tissue-type plasminogen activator during instability in coronary artery disease: effect on myocardial ischemia and need for coronary revascularization.
tissue-type plasminogen activator Binding (Thrombolysis) of in coronary artery associated with coronary artery disease and ischemia
6) Confidence 0.33 Published 1992 Journal Am. Heart J. Section Title Doc Link 1462894 Disease Relevance 0.91 Pain Relevance 0.36
Anistreplase has two distinct advantages over both streptokinase and alteplase: (1) it can be administered as a single bolus intravenous injection and (2) it has a longer half-life which may result in decreased reocclusion rates.
alteplase Binding (has) of
7) Confidence 0.29 Published 1990 Journal DICP Section Abstract Doc Link 2193460 Disease Relevance 0.25 Pain Relevance 0.09
Five genes from maternal data (CRHBP, FV, IL-5, tPA, and PTGER3) and three in fetal data (CBS, IL-10RA, and TREM1) that showed highly significant associations with PTB were analyzed for haplotype association.
tPA Binding (associations) of
8) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0 Pain Relevance 0
Five genes from maternal data (CRHBP, FV, IL-5, tPA, and PTGER3) and three in fetal data (CBS, IL-10RA, and TREM1) that showed highly significant associations with PTB were analyzed for haplotype association.
tPA Spec (analyzed) Binding (association) of
9) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0 Pain Relevance 0
The single most significant association was seen in tPA at rs879293 (allele p?
tPA Binding (association) of
10) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.13 Pain Relevance 0
These results indicate that Na+/H+ exchange is not essential either for spontaneous NK activity or for its activation by TPA and gamma-interferon.
TPA Binding (activation) of
11) Confidence 0.23 Published 1993 Journal Immunol. Lett. Section Abstract Doc Link 8389731 Disease Relevance 0 Pain Relevance 0.09
Compared with primary angioplasty [percutaneous transluminal coronary angioplasty (PTCA)], rescue PTCA is associated with lower angiographic success and higher reocclusion rates, especially after thrombolysis with tissue-type plasminogen activator (tPA).
tPA Binding (associated) of associated with percutaneous transluminal coronary angioplasty
12) Confidence 0.18 Published 1999 Journal Catheter Cardiovasc Interv Section Abstract Doc Link 10385150 Disease Relevance 0.14 Pain Relevance 0.31
Factor VIIIc, von Willebrand factor (vWF), tPA and PAI-1 are reported to be associated with CHD.
tPA Binding (associated) of associated with coronary artery disease
13) Confidence 0.18 Published 1997 Journal Int. J. Clin. Lab. Res. Section Abstract Doc Link 9352376 Disease Relevance 1.20 Pain Relevance 0.14
Tissue plasminogen activator and PAI-1 may partly reflect their mutual association with the inflammatory response.
Tissue plasminogen activator Binding (association) of associated with inflammatory response
14) Confidence 0.16 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 0.36 Pain Relevance 0.16
Compared with primary angioplasty [percutaneous transluminal coronary angioplasty (PTCA)], rescue PTCA is associated with lower angiographic success and higher reocclusion rates, especially after thrombolysis with tissue-type plasminogen activator (tPA).
tissue-type plasminogen activator Binding (associated) of associated with percutaneous transluminal coronary angioplasty
15) Confidence 0.16 Published 1999 Journal Catheter Cardiovasc Interv Section Abstract Doc Link 10385150 Disease Relevance 0.14 Pain Relevance 0.31
The enhanced activation was suggested to be caused by tetranectin’s ability to bind and accumulate tPA in an active conformation [53].
tPA Binding (bind) of
16) Confidence 0.15 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 0.41 Pain Relevance 0
While increased circulating free t-PA might increase fibrin lysis, no significant association of t-PA antigen was observed with fibrin D-dimer levels.40 (figure 2)

Future Potential Markers

t-PA Neg (no) Binding (association) of
17) Confidence 0.15 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 0.31 Pain Relevance 0.18
Lastly, as casts are also composed of fibrin, Enkhbaatar and colleagues (2004) experimented with aerosolised tissue plasminogen activator (TPA) in sheep.
TPA Binding (experimented) of
18) Confidence 0.13 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761179 Disease Relevance 0.37 Pain Relevance 0
Thrombolytic therapy with tissue plasminogen activator (tPA) for acute myocardial infarction may result in major bleeding complications such as gastrointestinal or intracranial bleeding.
tissue plasminogen activator Binding (therapy) of associated with cv general 4 under development, hemorrhage and myocardial infarction
19) Confidence 0.12 Published 1990 Journal Can J Cardiol Section Abstract Doc Link 2116935 Disease Relevance 0.83 Pain Relevance 0.15
Our association with tPA seen in maternal samples supports previous findings observing elevated levels of tPA in maternally derived decidua, but not in fetally derived amnion/chorion tissues [34], [35].
tPA Binding (association) of in amnion
20) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.28 Pain Relevance 0.06

General Comments

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