INT101013

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Context Info
Confidence 0.33
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 6.70
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-A)
Anatomy Link Frequency
leukocyte 3
optic 1
HLA-A (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 3 99.00 Very High Very High Very High
Multiple sclerosis 12 98.52 Very High Very High Very High
spinal inflammation 12 97.80 Very High Very High Very High
Inflammation 1 90.96 High High
Chronic pancreatitis 1 90.28 High High
Spinal cord 1 81.04 Quite High
Pain 3 75.00 Quite High
rheumatoid arthritis 2 69.24 Quite High
tolerance 1 66.00 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 6 99.76 Very High Very High Very High
Dystonia 5 99.50 Very High Very High Very High
Targeted Disruption 2 99.48 Very High Very High Very High
Disease 20 99.40 Very High Very High Very High
Optic Neuritis 3 99.24 Very High Very High Very High
Complex Regional Pain Syndromes 7 99.22 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 166 99.16 Very High Very High Very High
Demyelinating Disease 13 98.52 Very High Very High Very High
Low Back Pain 12 97.80 Very High Very High Very High
Genetic Predisposition To Disease 2 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite a longstanding knowledge about the familial associations of this disease, particularly among patients positive for human leukocyte antigen (HLA)-B27, the fundamental pathogenetic mechanism by which this disease arises in genetically susceptible individuals remains ill defined.
Regulation (positive) of HLA in leukocyte associated with disease
1) Confidence 0.33 Published 2008 Journal Neurosurg Focus Section Abstract Doc Link 18290741 Disease Relevance 0.74 Pain Relevance 0.33
However, most of the reports on the association of HLA-DRB1 with Kawasaki disease concluded that despite a regional association, their data failed to support a consistent role for HLA class II alleles in Kawasaki disease.
Regulation (role) of HLA associated with mucocutaneous lymph node syndrome
2) Confidence 0.25 Published 2007 Journal Pediatr Cardiol Section Body Doc Link PMC2267487 Disease Relevance 0.97 Pain Relevance 0
For example, the previously labeled HLA-Bw22 allele was changed to the HLA B54 allele [1, 3].
Regulation (changed) of HLA
3) Confidence 0.25 Published 2007 Journal Pediatr Cardiol Section Body Doc Link PMC2267487 Disease Relevance 1.02 Pain Relevance 0.10
The major purpose of the present study was to investigate the frequency of human leukocyte antigen (HLA)-B27 alleles in healthy controls and in patients with ankylosing spondylitis (AS) and other HLA-B27-related diseases in the Greek Cypriot population.
Spec (investigate) Regulation (frequency) of HLA in leukocyte associated with spinal inflammation and disease
4) Confidence 0.24 Published 2004 Journal Hum. Immunol. Section Abstract Doc Link 15603872 Disease Relevance 0.44 Pain Relevance 0.27
Linear and logistic regression models were used to evaluate the effect of human leucocyte antigen (HLA)-DR2 (DRB1*1501, DQB1*0602) on clinical outcome, taking account of correlation within families.
Regulation (effect) of HLA in leucocyte
5) Confidence 0.24 Published 2002 Journal Brain Section Abstract Doc Link 11834600 Disease Relevance 0.75 Pain Relevance 0.34
There was a complete concordance rate, thus confirming the potential of this new technique for clinical HLA-B27 typing and for HLA typing in general.
Regulation (potential) of HLA
6) Confidence 0.24 Published 2004 Journal Hum. Immunol. Section Abstract Doc Link 15336784 Disease Relevance 0.09 Pain Relevance 0.09
The involvement of HLA-B62 and HLA-DQ8 in CRPS with dystonia may indicate that these HLA loci are implicated in the susceptibility or expression of the disease.
Regulation (implicated) of HLA associated with complex regional pain syndromes, dystonia and disease
7) Confidence 0.20 Published 2009 Journal Pain Section Abstract Doc Link 19523767 Disease Relevance 1.41 Pain Relevance 0.20
Influence of HLA on progression of optic neuritis to multiple sclerosis: results of a four-year follow-up study.
Regulation (Influence) of HLA in optic associated with multiple sclerosis, optic neuritis and neuritis
8) Confidence 0.15 Published 2004 Journal Mult. Scler. Section Title Doc Link 15471368 Disease Relevance 0.57 Pain Relevance 0.37
We studied the role of single HLA genes in the development of AIP in transgenic mice.
Regulation (role) of HLA associated with targeted disruption and pancreatitis
9) Confidence 0.04 Published 2010 Journal Gastroenterology Section Abstract Doc Link 20303356 Disease Relevance 0.71 Pain Relevance 0.09

General Comments

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