INT101027

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 10.90
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (DST) endoplasmic reticulum (DST) cytoplasm (DST)
cell adhesion (DST) cell motility (DST) nucleus (DST)
Anatomy Link Frequency
liver 4
heart 2
urine 1
body 1
DST (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 44 100.00 Very High Very High Very High
Inflammatory marker 14 98.04 Very High Very High Very High
Serotonin 1 95.76 Very High Very High Very High
Dopamine 1 94.68 High High
Opioid 1 94.28 High High
adenocard 1 93.84 High High
Inflammation 84 93.44 High High
agonist 59 85.60 High High
Angina 56 85.36 High High
sodium channel 10 70.32 Quite High
Disease Link Frequency Relevance Heat
Heart Disease 182 100.00 Very High Very High Very High
Aids-related Complex 160 100.00 Very High Very High Very High
Cardiovascular Disease 200 99.80 Very High Very High Very High
Diabetes Mellitus 339 99.76 Very High Very High Very High
Stress 166 99.36 Very High Very High Very High
Anxiety Disorder 5 98.80 Very High Very High Very High
INFLAMMATION 84 98.04 Very High Very High Very High
Schizophrenia 166 97.52 Very High Very High Very High
Hallucination 2 96.52 Very High Very High Very High
Endometriosis (extended) 28 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DMH is an H(1) histamine receptor antagonist, but it interacts either directly or indirectly with other neurotransimitter systems, including those using acetylcholine, serotonin, norepinephrine, dopamine, opioids or adenosine.
DMH Binding (interacts) of associated with adenocard, dopamine, antagonist, opioid and serotonin
1) Confidence 0.41 Published 2002 Journal Neurosci Biobehav Rev Section Abstract Doc Link 11835984 Disease Relevance 0.28 Pain Relevance 0.29
The relevance of these mechanisms to the reported association between BPA and cardiovascular disease in the current study remains subjective.
BPA Binding (association) of associated with cardiovascular disease
2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.88 Pain Relevance 0.19
Detailed studies are needed to clarify the mechanisms explaining the statistical association between BPA and adult morbidity.



BPA Binding (association) of
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.50 Pain Relevance 0
Urinary BPA concentrations have previously been shown to be positively associated with oxidative stress markers.
BPA Binding (associated) of associated with stress
4) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.80 Pain Relevance 0.09
Regression models were adjusted for potential confounders, including socioeconomic markers which Calafat and colleagues [5] reported to be associated with BPA concentrations, and urinary creatinine to account for urine concentration [27].
BPA Binding (associated) of in urine
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.23 Pain Relevance 0
Positive associations were also reported between urinary BPA, MDA and 8-OHD, and with C-reactive protein, an inflammatory marker, in a cross-sectional study of 134 post-menopausal women, but not in men or pre-menopausal women from the same study [48].
BPA Binding (associations) of associated with endometriosis (extended) and inflammatory marker
6) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.61 Pain Relevance 0.11
In addition, the pooled estimates of association suggest that the new data is consistent with the original findings: larger samples will be needed to provide accurate estimates of BPA associations with diabetes or liver enzymes to exclude the possibility of real associations being present.
BPA Binding (associations) of in liver associated with diabetes mellitus
7) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.56 Pain Relevance 0
The BPA measures in NHANES are based on single spot specimens, so misclassification from this single snapshot of body burden will have resulted in a smaller (diluted) estimate of the strength of association between BPA and the conditions of interest: the true associations are likely to be much stronger.
BPA Binding (association) of in body
8) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.37 Pain Relevance 0
The estimated associations of BPA with reported diabetes in 2005/06 was modest but with wide confidence intervals; however, the diabetes association remained significant in pooled data (OR?
BPA Binding (associations) of associated with diabetes mellitus
9) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.83 Pain Relevance 0.09
We can now conclude that chance is an implausible explanation for the BPA association with heart disease.
BPA Binding (association) of in heart associated with heart disease
10) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.29 Pain Relevance 0.03
Replication of the BPA associations with diabetes and liver enzymes are less certain, with estimates for 2005/06 having wide confidence intervals and not reaching statistical significance.
BPA Binding (associations) of in liver associated with diabetes mellitus
11) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.29 Pain Relevance 0.03
Based on the animal and laboratory evidence, we previously hypothesised that higher urinary BPA concentrations would be associated with adverse human health effects, especially in the liver and in relation to insulin, cardiovascular disease and obesity.
BPA Binding (associated) of in liver associated with cardiovascular disease and obesity
12) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.36 Pain Relevance 0
It is pertinent to consider what is known of these previously reported associations, to place the current findings of associations with BPA into context.
BPA Binding (associations) of
13) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.61 Pain Relevance 0
More work is also needed to understand the mechanisms of effect underlying the BPA exposure heart disease association, including in vitro and in vivo studies.
BPA Binding (association) of in heart associated with heart disease
14) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.67 Pain Relevance 0
Associations of BPA concentration with diabetes and liver enzymes were not statistically significant in the 2005/06 data, although pooled estimates remained significant.
BPA Binding (Associations) of in liver associated with diabetes mellitus
15) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 1.26 Pain Relevance 0.03
Several studies in depressed patients have found an association of DST non-suppression (Jokinen and Nordstrom, 2009a; Jokinen et al., 2007; Mann et al., 2006) and suppression with suicide or suicide attempt (Black et al., 2002).
DST Binding (association) of associated with suicidal behaviour
16) Confidence 0.16 Published 2010 Journal Journal of Psychopharmacology (Oxford, England) Section Body Doc Link PMC2951595 Disease Relevance 1.30 Pain Relevance 0
BPA binds and modifies the activity of the estrogen receptor alpha (ESR1) in a very conservative way across organisms [14].
BPA Binding (binds) of
17) Confidence 0.06 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2873901 Disease Relevance 0.07 Pain Relevance 0.04
Oscillations of PER2::LUC bioluminescence in the SCN were of significantly higher amplitude than either micro-dissected DMH or Arc complex, or intact MBH cultures (SCN mean amplitude: 5426 ± 1215, relative bioluminescence; all p < 0.0001; ANOVA with a priori single degree of freedom comparisons; Table 1).
DMH Binding (complex) of associated with aids-related complex
18) Confidence 0.03 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.35 Pain Relevance 0.22
This is reflected in the damped circadian bioluminescence emissions when integrated across the entire DMH or Arc (Fig. 2B).
DMH Binding (integrated) of associated with aids-related complex
19) Confidence 0.03 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.41 Pain Relevance 0.03
At 8 d after L5T CATX activity increased strongly and highly significant (p ?
CATX Binding (activity) of
20) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.08 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox