INT101034

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Context Info
Confidence 0.65
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 8
Total Number 8
Disease Relevance 2.08
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NPEPPS) peptidase activity (NPEPPS) nucleus (NPEPPS)
cytoplasm (NPEPPS)
Anatomy Link Frequency
cartilage 1
putamen 1
tendon 1
cleavage 1
hippocampus 1
NPEPPS (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 18 100.00 Very High Very High Very High
Enkephalin 23 99.98 Very High Very High Very High
Hippocampus 10 97.76 Very High Very High Very High
Opioid 1 95.24 Very High Very High Very High
Snapping jaw 7 94.32 High High
Pain 2 89.44 High High
Inflammation 11 79.84 Quite High
rheumatoid arthritis 45 72.88 Quite High
cytokine 7 67.36 Quite High
Angina 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 4 97.44 Very High Very High Very High
Disease 15 97.20 Very High Very High Very High
Myocardial Infarction 4 95.88 Very High Very High Very High
Temporomandibular Joint Syndrome 7 94.32 High High
Tendinopathy 5 93.72 High High
Sprains And Strains 1 91.16 High High
INFLAMMATION 11 79.84 Quite High
Rheumatoid Arthritis 47 72.88 Quite High
Necrosis 4 69.56 Quite High
Cancer 4 69.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present work studies enkephalin-degrading enzyme activities, puromycin-sensitive alanyl aminopeptidase (AAP-S), puromycin-insensitive alanyl aminopeptidase N (Ap N) and neprilysin (NEP) in human seminal fractions.
Protein_catabolism (degrading) of alanyl aminopeptidase associated with enkephalin
1) Confidence 0.65 Published 2002 Journal Peptides Section Abstract Doc Link 11835995 Disease Relevance 0 Pain Relevance 0.29
Bacitracin-sensitive aminopeptidase(s) degradation of methionine(5)-enkephalin by human brain putamen and hippocampus preparations: inhibition by phenothiazine drugs.
Protein_catabolism (degradation) of Bacitracin-sensitive aminopeptidase in hippocampus associated with hippocampus and enkephalin
2) Confidence 0.58 Published 2009 Journal Am J Ther Section Title Doc Link 19797941 Disease Relevance 0 Pain Relevance 0.60
Bacitracin-sensitive aminopeptidase(s) degradation of methionine(5)-enkephalin by human brain putamen and hippocampus preparations: inhibition by phenothiazine drugs.
Protein_catabolism (degradation) of Bacitracin-sensitive aminopeptidase in putamen associated with hippocampus and enkephalin
3) Confidence 0.20 Published 2009 Journal Am J Ther Section Title Doc Link 19797941 Disease Relevance 0 Pain Relevance 0.60
Metalloproteinase enzymes have an important role in the tendon matrix, being responsible for the degradation of collagen and proteoglycan in both healthy patients and those with disease.
Protein_catabolism (degradation) of Metalloproteinase in tendon associated with metalloproteinase and disease
4) Confidence 0.06 Published 2008 Journal Nature clinical practice. Rheumatology Section Abstract Doc Link 18235537 Disease Relevance 0.59 Pain Relevance 0.27
The key mediators of cartilage degradation include the MMPs (Matrix Metallo Proteases) and the closely related ADAM-TS (a disintegrin and metalloproteinase with thrombospondin motifs) [10].
Protein_catabolism (degradation) of metalloproteinase in cartilage associated with metalloproteinase
5) Confidence 0.01 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2426686 Disease Relevance 0.65 Pain Relevance 0.37
Mitochondrial ROS generation following acetylcholine-induced EGF receptor transactivation requires metalloproteinase cleavage of proHB-EGF.
Protein_catabolism (cleavage) of metalloproteinase in cleavage associated with metalloproteinase
6) Confidence 0.01 Published 2004 Journal J. Mol. Cell. Cardiol. Section Title Doc Link 15010282 Disease Relevance 0 Pain Relevance 0.16
Novel nonmatrix-metalloproteinase-mediated collagen degradation.
Protein_catabolism (degradation) of nonmatrix-metalloproteinase-mediated associated with metalloproteinase
7) Confidence 0.01 Published 2005 Journal Biochim. Biophys. Acta Section Title Doc Link 15652180 Disease Relevance 0.56 Pain Relevance 0.84
BACKGROUND: The Fas ligand (FasL) is rapidly cleaved off by a metalloproteinase from the cell membrane to become a soluble form as a cytokine.
Protein_catabolism (cleaved) of metalloproteinase
8) Confidence 0.00 Published 2002 Journal J. Am. Coll. Cardiol. Section Body Doc Link 11849855 Disease Relevance 0.29 Pain Relevance 0

General Comments

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