INT101038

Context Info Confidence 0.36 First Reported 2002 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 0.36 Pain Relevance 2.31

extracellular region (CHSY1) Golgi apparatus (CHSY1)

Anatomy Link Frequency plasma 1 CHSY1 (Homo sapiens)

Pain Link Frequency Relevance Heat Ultiva 20 99.92 local anesthetic 22 98.60 Catecholamine 8 95.66 anesthesia 10 94.68 lidocaine 2 69.36 Pain 14 58.08 antagonist 4 50.00 corticosteroid 1 5.00 withdrawal 1 5.00 cINOD 1 5.00

Disease Link Frequency Relevance Heat Cv Unclassified Under Development 8 95.20 Diabetes Mellitus 2 83.00 Syndrome 6 63.24 Pain 14 58.08 Anxiety Disorder 30 57.72 Coronary Heart Disease 2 40.72 Emergencies 2 25.88 Asthma 3 5.00 Pressure And Volume Under Development 2 5.00 Toxicity 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Css increases by a factor of 1.8 when the weight doubles, and Css in a 75-year-old is 1.5 times higher than Css in a 25-year-old.

Positive_regulation (increases) of Css

1) Confidence 0.36 Published 2007 Journal Masui Section Abstract Doc Link 18027597 Disease Relevance 0 Pain Relevance 0.86

However, remifentanil concentration does not reach the Css immediately with constant rate infusion.

Neg (not) Positive_regulation (reach) of Css associated with ultiva

2) Confidence 0.36 Published 2007 Journal Masui Section Abstract Doc Link 18027597 Disease Relevance 0 Pain Relevance 0.92

Fifteen minutes after the initiation of the procedure, new measurements of SyBP, DiBP, HR and GLU were performed.

Positive_regulation (measurements) of SyBP

3) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2972604 Disease Relevance 0 Pain Relevance 0.09

Nakamura et al.10 investigated the changes in blood pressure, plasma catecholamines, glucose, and insulin concentrations in 11 normotensive patients during dental surgery and found that the administration of both local anesthetics and tooth extraction activates sympathoadrenal outflow, resulting in increases of the SyBP, HR, plasma epinephrine, and serum glucose concentrations.

Positive_regulation (increases) of SyBP in plasma associated with catecholamine, cv unclassified under development and local anesthetic

4) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2972604 Disease Relevance 0.29 Pain Relevance 0.44

We believe that the use of LTAs should not be influenced by the apparent increase in the incidence of CSS and that these are still safe drugs for asthma.

Positive_regulation (increase) of CSS

5) Confidence 0.02 Published 2002 Journal Semin. Arthritis Rheum. Section Body Doc Link 11836655 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.