INT10104

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Context Info
Confidence 0.59
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 43
Total Number 46
Disease Relevance 15.63
Pain Relevance 7.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
plasma 10
spike 2
fibroblasts 2
endothelium 2
smooth muscle 1
Edn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 49 100.00 Very High Very High Very High
Morphine 6 99.98 Very High Very High Very High
metalloproteinase 3 99.98 Very High Very High Very High
c fibre 3 99.56 Very High Very High Very High
potassium channel 2 99.20 Very High Very High Very High
antagonist 172 99.00 Very High Very High Very High
Clonidine 15 98.96 Very High Very High Very High
fibrosis 11 98.60 Very High Very High Very High
Rostral ventrolateral medulla 6 98.00 Very High Very High Very High
Calcitonin gene-related peptide 119 94.48 High High
Disease Link Frequency Relevance Heat
Hypertension 121 100.00 Very High Very High Very High
Bradycardia 1 100.00 Very High Very High Very High
Systemic Sclerosis 68 99.82 Very High Very High Very High
Hypoxia 12 99.82 Very High Very High Very High
Apoptosis 26 99.74 Very High Very High Very High
Diabetes Mellitus 147 99.72 Very High Very High Very High
Increased Venous Pressure Under Development 124 99.60 Very High Very High Very High
Stroke 6 99.46 Very High Very High Very High
Reprotox - General 2 148 99.38 Very High Very High Very High
Nociception 11 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rat isolated aorta was more sensitive to the contractile effect of endothelin-1 (ET-1) when the endothelium was removed.
Negative_regulation (effect) of endothelin-1 in endothelium
1) Confidence 0.59 Published 1989 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2473283 Disease Relevance 0 Pain Relevance 0.23
Rat isolated aorta was more sensitive to the contractile effect of endothelin-1 (ET-1) when the endothelium was removed.
Negative_regulation (effect) of ET-1 in endothelium
2) Confidence 0.59 Published 1989 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2473283 Disease Relevance 0 Pain Relevance 0.23
ET-1 were abolished after intravenous pretreatment with phentolamine.
Negative_regulation (abolished) of ET-1
3) Confidence 0.58 Published 1999 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 10367590 Disease Relevance 0.26 Pain Relevance 0.30
Inhibitors of endothelin (ET), which is a potent vasoconstrictor produced in the vascular endothelium, may also improve pulmonary hypertension.
Negative_regulation (Inhibitors) of endothelin in vascular endothelium associated with hypertension
4) Confidence 0.57 Published 2009 Journal Pediatr Surg Int Section Body Doc Link PMC2734260 Disease Relevance 1.07 Pain Relevance 0.07
Endothelin-1 levels significantly decreased after coronary revascularization [before: mean 1.81 pg mL-1 (SEM 0.15, n = 14); after: mean 1.16 pg mL-1 (SEM 0.11), P < 0.002], without changes in the peptide response to both tests.
Negative_regulation (decreased) of Endothelin-1
5) Confidence 0.56 Published 1997 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 9229234 Disease Relevance 0.31 Pain Relevance 0.08
Coronary revascularization was followed by a significant decrease in plasma endothelin-1 levels.
Negative_regulation (decrease) of endothelin-1 in plasma
6) Confidence 0.56 Published 1997 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 9229234 Disease Relevance 0.29 Pain Relevance 0.09
The long-acting anesthetics bupivacaine and ropivacaine (P < 0.05), but not procaine, reduced ET-1 levels, produced low inflammation rates, and did not affect lung structures at doses from 10(-3) to 10(-6) mg/kg.
Negative_regulation (reduced) of ET-1 in lung
7) Confidence 0.55 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19690261 Disease Relevance 0 Pain Relevance 0
The inhibition of endothelin-1 was enhanced when BQ-123 was preincubated for 30 min instead of 15 min.
Negative_regulation (inhibition) of endothelin-1
8) Confidence 0.51 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8982672 Disease Relevance 0.05 Pain Relevance 0.21
Pretreatment with diltiazem at a dose of 2 mg kg-1 intravenously protected against sudden death induced by intravenous administration of endothelin-1 (ET-1, 5 nmol kg-1), with an apparent decrease in the plasma immunoreactive-ET-1 (IR-ET-1) in mice.
Negative_regulation (decrease) of IR-ET-1 in plasma associated with sudden death
9) Confidence 0.51 Published 1994 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 8027928 Disease Relevance 0.10 Pain Relevance 0
Pretreatment with diltiazem at a dose of 2 mg kg-1 intravenously protected against sudden death induced by intravenous administration of endothelin-1 (ET-1, 5 nmol kg-1), with an apparent decrease in the plasma immunoreactive-ET-1 (IR-ET-1) in mice.
Negative_regulation (decrease) of immunoreactive-ET-1 in plasma associated with sudden death
10) Confidence 0.51 Published 1994 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 8027928 Disease Relevance 0.10 Pain Relevance 0
Pretreatment with gastroprotective agent, sulglycotide, led to a 51.2% reduction in the extent of mucosal damage caused by indomethacin, a 43.9% decrease in apoptosis, and a 63.5% decrease in ET-1, while the expression of cNOS increased by 3.4-fold and the level of IL-4 showed a 32.2% increase.
Negative_regulation (decrease) of ET-1 associated with apoptosis
11) Confidence 0.51 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10424717 Disease Relevance 0.54 Pain Relevance 0.14
Pretreatment with H2-receptor antagonist, ranitidine produced a 15.7% reduction in the mucosal damage caused by indomethacin, 29.5% decrease in epithelial cell apoptosis and a 19.6% reduction in ET-1, while the expression of IL-4 increased by 10.8% and that of cNOS showed a 2-fold increase.
Negative_regulation (reduction) of ET-1 in epithelial cell associated with antagonist and apoptosis
12) Confidence 0.51 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10424717 Disease Relevance 0.66 Pain Relevance 0.10
Furthermore, in anaesthetized rats, diltiazem inhibited ET-1-induced decreases in renal blood flow and increased renal accumulation of IR-ET-1.
Negative_regulation (decreases) of ET-1-induced in blood
13) Confidence 0.43 Published 1994 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 8027928 Disease Relevance 0.08 Pain Relevance 0
In animals given phosphoramidon (0.25 mg/kg per min i.v.), a metalloproteinase inhibitor, the hypertensive effect of big endothelin-1 was markedly attenuated.
Negative_regulation (inhibitor) of endothelin-1 associated with hypertension and metalloproteinase
14) Confidence 0.43 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2226629 Disease Relevance 0.36 Pain Relevance 0.13
Yohimbine, at concentrations of 1, 3 or 10 microM, significantly decreased the EC50 values for endothelin-1 to 16.4 +/- 1.02 nM, 16.1 +/- 1.60 nM and 8.09 +/- 1.15 nM, respectively.
Negative_regulation (decreased) of endothelin-1
15) Confidence 0.43 Published 1992 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 1463373 Disease Relevance 0 Pain Relevance 0.49
We also determined ET-1 concentration in aortic and portal venous blood (draining the nonhepatic splanchnic organs) in anesthetized and conscious sham and DOCA-salt rats before and after acute blockade of ETB receptor-mediated plasma clearance of ET-1.
Negative_regulation (blockade) of ET-1 in plasma
16) Confidence 0.43 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15471983 Disease Relevance 0.30 Pain Relevance 0
In this study, we examined whether vasomotor and respiratory neurons in RVLM participate in above-mentioned responses and whether those neurons respond to direct iontophoretic application of ET-1 and/or an ET-A receptor antagonist, FR139317. 2.
Spec (whether) Negative_regulation (application) of ET-1 in neurons associated with rostral ventrolateral medulla and antagonist
17) Confidence 0.43 Published 2003 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 14514025 Disease Relevance 0.16 Pain Relevance 0.32
ET-1 (0.1 nM-0.1 microM) reversed the inhibitory effect of clonidine on the FES-evoked contractions whereas ET-1 applied before clonidine exerted a dual effect on the clonidine-induced inhibition of the FES-evoked contractions. 4.
Negative_regulation (reversed) of ET-1 associated with clonidine
18) Confidence 0.43 Published 1992 Journal Gen. Pharmacol. Section Abstract Doc Link 1511861 Disease Relevance 0 Pain Relevance 0.55
BP, cardiac output, and stroke volume were significantly decreased 30, 60, and 120 min after central administration of ET-1.
Negative_regulation (decreased) of ET-1 associated with pressure volume 2 under development and stroke
19) Confidence 0.43 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9321804 Disease Relevance 0.36 Pain Relevance 0.11
However, vasomotor tone rapidly recovered in absence of vasodilators and ET-1 (Fig. 2D).
Negative_regulation (absence) of ET-1
20) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879375 Disease Relevance 0 Pain Relevance 0.44

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