INT101040

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Context Info
Confidence 0.30
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.35
Pain Relevance 0.25

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small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
signal transducer activity (MC3R) extracellular space (POMC) generation of precursor metabolites and energy (POMC)
MC3R (Homo sapiens)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 3 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 3 98.88 Very High Very High Very High
Diabetes Mellitus 1 85.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The yellow coat colour is the result of agouti chronically antagonizing the binding of alpha-MSH to Mc1r and the obese phenotype results from agouti protein antagonizing the binding of alpha-MSH to Mc3r and/or Mc4r.
Mc3r Binding (binding) of alpha-MSH associated with melanocortin 1 receptor and obesity
1) Confidence 0.30 Published 2002 Journal Pigment Cell Res. Section Abstract Doc Link 11837451 Disease Relevance 0.35 Pain Relevance 0.25

General Comments

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