INT10106

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Context Info
Confidence 0.50
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 5.86
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Msr1) plasma membrane (Msr1)
Anatomy Link Frequency
macrophages 1
dorsal root 1
poly 1
finger 1
Msr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 48 100.00 Very High Very High Very High
antagonist 7 100.00 Very High Very High Very High
Paracetamol 7 99.46 Very High Very High Very High
Gabapentin 8 96.00 Very High Very High Very High
GABAergic 7 95.72 Very High Very High Very High
Analgesic 21 94.92 High High
agonist 55 93.64 High High
gABA 1 92.00 High High
Enkephalin 1 90.72 High High
nerve block 1 85.04 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 58 100.00 Very High Very High Very High
Adhesions 14 100.00 Very High Very High Very High
Pathologic Processes 3 99.78 Very High Very High Very High
Increased Venous Pressure Under Development 6 99.12 Very High Very High Very High
Aids-related Complex 2 98.28 Very High Very High Very High
Diabetes Mellitus 21 97.76 Very High Very High Very High
Apoptosis 33 96.68 Very High Very High Very High
Coronary Heart Disease 31 96.64 Very High Very High Very High
Atherosclerosis 21 87.12 High High
Death 16 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The non-pyrazolones, acetaminophen and indomethacin, did not increase the MSR and PSR.
Neg (not) Positive_regulation (increase) of MSR associated with paracetamol
1) Confidence 0.50 Published 1992 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 1464397 Disease Relevance 0 Pain Relevance 0.35
The amplitude of DRR decreased by aminopyrine was reversed by diazepam at 0.2 mg/kg, i.v.; however, the increased amplitudes of MSR and PSR were not affected by diazepam.
Positive_regulation (increased) of MSR
2) Confidence 0.50 Published 1992 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 1464397 Disease Relevance 0 Pain Relevance 0.19
Isopropylantipyrine at 50 mg/kg, i.v. produced increases in MSR and PSR.
Positive_regulation (increases) of MSR
3) Confidence 0.50 Published 1992 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 1464397 Disease Relevance 0 Pain Relevance 0.37
Methysergide at 1 mg/kg, i.v. antagonized this increasing effect of aminopyrine on MSR and PSR.
Positive_regulation (increasing) of MSR
4) Confidence 0.50 Published 1992 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 1464397 Disease Relevance 0 Pain Relevance 0.25
Pretreatment of semicarbazide at 200 mg/kg, i.v. did not influence the increasing effect of aminopyrine on MSR and PSR.
Positive_regulation (increasing) of MSR
5) Confidence 0.50 Published 1992 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 1464397 Disease Relevance 0 Pain Relevance 0.19
In DL-5-hydroxytryptophan-treated cats, the amplitude of MSR was further increased by aminopyrine.
Positive_regulation (increased) of MSR
6) Confidence 0.34 Published 1992 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 1464397 Disease Relevance 0 Pain Relevance 0.24
Aminopyrine at 25-100 mg/kg, i.v. produced a marked increase in mono- and poly-synaptic reflex potentials (MSR and PSR), and a decrease in dorsal root reflex potentials (DRR) in a dose-dependent manner.
Positive_regulation (increase) of MSR in poly
7) Confidence 0.34 Published 1992 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 1464397 Disease Relevance 0 Pain Relevance 0.17
These results suggest that the structural properties of 1- and 5-substituents are primarily responsible for the antagonist activity of SR141716A.
Positive_regulation (responsible) of SR141716A associated with antagonist
8) Confidence 0.29 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11181936 Disease Relevance 0.06 Pain Relevance 0.41
The SR-A receptors occur in two different forms that are generated by alternative splicing of the primary transcript: SR-AI and SR-AII.
Positive_regulation (generated) of SR-AI
9) Confidence 0.27 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1562429 Disease Relevance 1.79 Pain Relevance 0.08
The SR-A receptors occur in two different forms that are generated by alternative splicing of the primary transcript: SR-AI and SR-AII.
Positive_regulation (generated) of SR-AII
10) Confidence 0.27 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1562429 Disease Relevance 1.80 Pain Relevance 0.08
Stimulation of the dorsal root at L5 elicited the segmental mono-(MSR) and polysynaptic reflex (PSR) in the ipsilateral ventral root.
Positive_regulation (elicited) of MSR in dorsal root
11) Confidence 0.19 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15599106 Disease Relevance 0.24 Pain Relevance 0.80
This novel MSR is generated from the FPL tendon and stimulates contraction of the long finger flexors.
Positive_regulation (generated) of MSR in finger
12) Confidence 0.09 Published 2009 Journal Muscle Nerve Section Abstract Doc Link 19623633 Disease Relevance 0.34 Pain Relevance 0.09
In addition, a new soluble Msr activity was also detected in the soluble extracts of the double mutant that specifically reduces the S epimer of met(o) in proteins.
Positive_regulation (detected) of Msr
13) Confidence 0.04 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12604343 Disease Relevance 0 Pain Relevance 0.09
activation by major oxidized lipid components of ox-LDL, 9-HODE and 13-HODE has an important role in the development of lipid-accumulating macrophages through transcriptional induction of CD36, a scavenger receptor
Positive_regulation (induction) of scavenger receptor in macrophages
14) Confidence 0.02 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 0.54 Pain Relevance 0.04
CD36 is a glycoprotein associated with normal and pathologic processes including scavenger receptor functions, lipid metabolism and fatty acid transport, cell adhesion, angiogenesis, modulation of inflammation, activation of TGF-?
Positive_regulation (activation) of scavenger receptor associated with pathologic processes, inflammation and adhesions
15) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.10 Pain Relevance 0.05
Based on binding, functional, and pharmacological data, this study introduces SR147778 [5-(4-bromophenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide] as a highly potent, selective, and orally active antagonist for the CB1 receptor.
Positive_regulation (introduces) of SR147778 associated with antagonist
16) Confidence 0.00 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15131245 Disease Relevance 0 Pain Relevance 0.12

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