INT101083

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 4.12
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fgf2) extracellular space (Fgf2) extracellular region (Fgf2)
nucleus (Fgf2) embryo development (Fgf2) cytoplasm (Fgf2)
Anatomy Link Frequency
fibroblast 2
amnion 1
duct 1
neural 1
glial cells 1
Fgf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 66 100.00 Very High Very High Very High
cytokine 65 100.00 Very High Very High Very High
Dopamine 26 99.68 Very High Very High Very High
neurotrophin 3 14 97.72 Very High Very High Very High
Nerve growth factor 72 97.40 Very High Very High Very High
antagonist 96 96.56 Very High Very High Very High
Hippocampus 27 93.52 High High
Spinal cord 85 90.20 High High
Clonidine 4 90.20 High High
agonist 58 89.52 High High
Disease Link Frequency Relevance Heat
Cancer 59 100.00 Very High Very High Very High
Necrosis 23 98.64 Very High Very High Very High
Skin Cancer 6 98.56 Very High Very High Very High
Metastasis 1 98.22 Very High Very High Very High
Neurodegenerative Disease 23 97.92 Very High Very High Very High
Apoptosis 46 95.80 Very High Very High Very High
Diabetes Mellitus 73 93.20 High High
Retinal Degeneration 29 91.04 High High
Hernia 52 89.72 High High
Diabetic Neuropathy 27 87.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among FGFs, in vivo and in vitro studies have revealed that basic FGF (FGF-2) has been recognized as an important neuro-survival factor.
FGF-2 Binding (recognized) of
1) Confidence 0.42 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699806 Disease Relevance 0.79 Pain Relevance 0.03
Two weeks after ductal ligation, the ligature was removed, and various amounts of bFGF, isoproterenol, or saline were administered via a retrograde duct instillation.
bFGF Binding (ligation) of in duct
2) Confidence 0.37 Published 2000 Journal Adv. Dent. Res. Section Abstract Doc Link 11842932 Disease Relevance 0.07 Pain Relevance 0.07
The ECoG was analyzed 2, 5, and 9 weeks after intraperitoneal injection of KA alone or in combination with basic fibroblast growth factor (bFGF, intracerebroventricularly).
basic fibroblast growth factor Binding (combination) of in fibroblast
3) Confidence 0.36 Published 2005 Journal Brain Res. Section Abstract Doc Link 15996643 Disease Relevance 0.21 Pain Relevance 0.48
The ECoG was analyzed 2, 5, and 9 weeks after intraperitoneal injection of KA alone or in combination with basic fibroblast growth factor (bFGF, intracerebroventricularly).
bFGF Binding (combination) of in fibroblast
4) Confidence 0.36 Published 2005 Journal Brain Res. Section Abstract Doc Link 15996643 Disease Relevance 0.21 Pain Relevance 0.48
As control, sections were incubated overnight at 4°C with the FGF-2 antiserum (diluted 1:800) pre-incubated with human recombinant FGF-2 (50 ?
FGF-2 Binding (recombinant) of
5) Confidence 0.33 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.07 Pain Relevance 0
As mentioned above, it can be speculated that VEGF and bFGF supplied by transplanted MSCs contributed to the improvement of NCV through the amelioration of NBF or direct actions to axons and Schwann cells.
bFGF Binding (supplied) of in Schwann cells
6) Confidence 0.32 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.39 Pain Relevance 0.46
bFGF: basic fibroblast growth factor; CA: constitutive active form; CNS: central nervous system; DN: dominant negative form; GFP: green fluorescent protein; JNK: c-jun N-terminal kinase; NSPC: neural stem/progenitor cell; p75NTR: p75 neurotrophin receptor; ssDNA: single stranded DNA; TNF: tumor necrosis factor.


bFGF Binding (ssDNA) of in neural associated with necrosis, cancer and central nervous system
7) Confidence 0.24 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.32 Pain Relevance 0.21
Pena et al. have shown that i.v. injections of FGF-2 5 min. before, immediately after and 1 h after total body irradiation in mice (1–20 Gy or 50 Gy) significantly reduced the number of apoptotic vascular and glial cells in the CNS [6].
FGF-2 5 Binding (injections) of in glial cells associated with central nervous system and apoptosis
8) Confidence 0.16 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1933540 Disease Relevance 0.37 Pain Relevance 0.29
and FGF-2 inhibit it and dopamine completely blocks the VIP-stimulated secretion.
FGF-2 Neg (inhibit) Binding (inhibit) of associated with dopamine
9) Confidence 0.14 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.08 Pain Relevance 0.59
3 appears to be FGF-2 produced by FS cells, because immunoneutralisation of FGF-2 abolishes the effect of TGF-?
FGF-2 Binding (appears) of
10) Confidence 0.14 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.18 Pain Relevance 0
AMP cells could be making the necessary cytokine cocktail at the proper time and dose to effect a trajectory shift—already proven by our group for individual cytokines such as TGF-B2, bFGF, and GM-CSF.2, 4, 35 The immune privilege of amnion-derived cells allows them to function when applied as an allograft or xenograft.17
bFGF Binding (group) of in amnion associated with cytokine
11) Confidence 0.12 Published 2007 Journal J Burns Wounds Section Body Doc Link PMC2064968 Disease Relevance 0.64 Pain Relevance 0.10
In another study, the synergistic interaction between bFGF and ATP was reported on DNA synthesis in primary cultures of rat cortical astrocytes.
bFGF Binding (interaction) of in astrocytes
12) Confidence 0.10 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0 Pain Relevance 0.19
All studied degenerated discs showed immunoreactivity for TGFbeta receptor type II and bFGF.
bFGF Binding (immunoreactivity) of
13) Confidence 0.09 Published 2006 Journal Eur Spine J Section Abstract Doc Link 15980999 Disease Relevance 0.08 Pain Relevance 0.08
As well, heparin, the dominant mast cell proteoglycan, assists in blood-borne metastasis. (3) Degradation of extracellular matrix: Through its own proteases, and indirectly via interaction with other cells, mast cells participate in degradation of the matrix, which is required for tumor spread. (4) Mitogenesis: Mast cell mediators including fibroblast growth factor-2 and interleukin-8 are mitogenic to melanoma cells.
fibroblast growth factor-2 Binding (interaction) of in Mast cell associated with cancer, skin cancer and metastasis
14) Confidence 0.07 Published 2006 Journal Mod. Pathol. Section Abstract Doc Link 16258517 Disease Relevance 0.69 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox