INT101088

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Context Info
Confidence 0.06
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.76
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNN1)
Anatomy Link Frequency
DRG 1
KCNN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 6 99.98 Very High Very High Very High
Pain 4 93.16 High High
Action potential 2 88.84 High High
tetrodotoxin 41 51.96 Quite High
Nerve growth factor 8 34.64 Quite Low
neurotrophin 3 6 30.76 Quite Low
sodium channel 2 25.00 Low Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 4 93.16 High High
Nervous System Injury 4 92.56 High High
Breast Cancer 1 82.40 Quite High
Cicatrix 1 76.80 Quite High
Injury 7 74.64 Quite High
Wallerian Degeneration 2 46.56 Quite Low
Apoptosis 2 33.04 Quite Low
Myocardial Infarction 2 5.00 Very Low Very Low Very Low
Fibrosis 1 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using specific antibodies, hSK-1 and hIK-1-like immunoreactivity was detected in a majority of large and small/medium-sized cell bodies of human DRG. hSK1 immunoreactivity was decreased significantly in cell bodies of avulsed human DRG (n = 8, surgery delay 8 h to 12 months).
Regulation (immunoreactivity) of hSK-1 in DRG
1) Confidence 0.06 Published 2002 Journal Brain Section Abstract Doc Link 11844726 Disease Relevance 0.30 Pain Relevance 0.16
Calcium-activated potassium channel SK1- and IK1-like immunoreactivity in injured human sensory neurones and its regulation by neurotrophic factors.
Regulation (regulation) of SK1 associated with potassium channel
2) Confidence 0.05 Published 2002 Journal Brain Section Title Doc Link 11844726 Disease Relevance 0.30 Pain Relevance 0.19
KCa1.1) channels was regulated by the spontaneous Ca2+ oscillations, resulting in fluctuations of membrane currents and potentials.
Regulation (regulated) of KCa1
3) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0.16 Pain Relevance 0.05

General Comments

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