INT101088

Context Info Confidence 0.06 First Reported 2002 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.76 Pain Relevance 0.40

plasma membrane (KCNN1)

Anatomy Link Frequency DRG 1 KCNN1 (Homo sapiens)

Pain Link Frequency Relevance Heat potassium channel 6 99.98 Pain 4 93.16 Action potential 2 88.84 tetrodotoxin 41 51.96 Nerve growth factor 8 34.64 neurotrophin 3 6 30.76 sodium channel 2 25.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Pain 4 93.16 Nervous System Injury 4 92.56 Breast Cancer 1 82.40 Cicatrix 1 76.80 Injury 7 74.64 Wallerian Degeneration 2 46.56 Apoptosis 2 33.04 Myocardial Infarction 2 5.00 Fibrosis 1 5.00 Hypertension 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Using specific antibodies, hSK-1 and hIK-1-like immunoreactivity was detected in a majority of large and small/medium-sized cell bodies of human DRG. hSK1 immunoreactivity was decreased significantly in cell bodies of avulsed human DRG (n = 8, surgery delay 8 h to 12 months).

Regulation (immunoreactivity) of hSK-1 in DRG

1) Confidence 0.06 Published 2002 Journal Brain Section Abstract Doc Link 11844726 Disease Relevance 0.30 Pain Relevance 0.16

Calcium-activated potassium channel SK1- and IK1-like immunoreactivity in injured human sensory neurones and its regulation by neurotrophic factors.

Regulation (regulation) of SK1 associated with potassium channel

2) Confidence 0.05 Published 2002 Journal Brain Section Title Doc Link 11844726 Disease Relevance 0.30 Pain Relevance 0.19

KCa1.1) channels was regulated by the spontaneous Ca2+ oscillations, resulting in fluctuations of membrane currents and potentials.

Regulation (regulated) of KCa1

3) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0.16 Pain Relevance 0.05

General Comments

This test has worked.