INT101090

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Context Info
Confidence 0.77
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 2.98
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (IKZF1) intracellular (IKZF1) cell cycle (IKZF1)
DNA binding (IKZF1) cytoplasm (IKZF1)
Anatomy Link Frequency
peripheral nerves 1
ganglia 1
salivary glands 1
placenta 1
IKZF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
neurotrophin 3 6 99.76 Very High Very High Very High
Nerve growth factor 8 99.68 Very High Very High Very High
Inflammation 5 98.72 Very High Very High Very High
Action potential 26 98.28 Very High Very High Very High
Crohn's disease 1 96.96 Very High Very High Very High
Pain 7 93.48 High High
sodium channel 5 92.16 High High
trk C 1 91.04 High High
Calcium channel 3 85.20 High High
abdominal pain 1 76.24 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 98.72 Very High Very High Very High
Inflammatory Bowel Disease 2 97.88 Very High Very High Very High
Disease 3 96.96 Very High Very High Very High
Salivary Gland Disease 2 95.56 Very High Very High Very High
Shock 213 95.32 Very High Very High Very High
Nervous System Injury 4 94.40 High High
Pain 4 93.48 High High
Arrhythmias 2 Under Development 78 91.84 High High
Injury 6 85.44 High High
Wallerian Degeneration 2 79.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurotrophin-3 (NT-3), which regulates IK1 expression, was also observed in fewer neurons of the myenteric ganglia in Crohn's bowel (p = 0.048), and in inflamed colonic extracts by Western blotting (p = 0.004); the numbers of neurons expressing the NT-3 high affinity receptor trk C were unchanged.
Gene_expression (expression) of IK1 in ganglia associated with trk c
1) Confidence 0.77 Published 2003 Journal Neuroreport Section Abstract Doc Link 12598727 Disease Relevance 0.35 Pain Relevance 0.24
IK1 mRNA was present in surface-rich, secretory and inflammatory cell-rich tissues, highest in the trachea, prostate, placenta and salivary glands.
Gene_expression (present) of IK1 in salivary glands associated with inflammation and salivary gland disease
2) Confidence 0.60 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15127180 Disease Relevance 0.26 Pain Relevance 0.12
The IK1 stabilizes the resting membrane potential and is responsible for shaping the initial depolarization and final repolarization of the action potential [58].
Gene_expression (stabilizes) of IK1 associated with action potential
3) Confidence 0.24 Published 2010 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2803603 Disease Relevance 0.42 Pain Relevance 0.15
IK1 mRNA was present in surface-rich, secretory and inflammatory cell-rich tissues, highest in the trachea, prostate, placenta and salivary glands.
Gene_expression (present) of IK1 in placenta associated with inflammation and salivary gland disease
4) Confidence 0.21 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15127180 Disease Relevance 0.26 Pain Relevance 0.12
Inhibition of the typical outward currents IK1 and Ito do not reduce the ?
Gene_expression (typical) of IK1
5) Confidence 0.21 Published 2010 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2803603 Disease Relevance 0.57 Pain Relevance 0.11
Inhibition of the typical outward currents IK1 and Ito do not reduce the ?
Gene_expression (outward) of IK1
6) Confidence 0.21 Published 2010 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2803603 Disease Relevance 0.57 Pain Relevance 0.11
NT-3 stimulated hIK1 expression, while NGF and GDNF were ineffective.
Gene_expression (expression) of hIK1 associated with nerve growth factor and neurotrophin 3
7) Confidence 0.07 Published 2002 Journal Brain Section Abstract Doc Link 11844726 Disease Relevance 0.30 Pain Relevance 0.54
We studied the presence and changes of human SK1 (hSK1)- and hIK1-like immunoreactivity in control and injured human dorsal root ganglia (DRG) and peripheral nerves and their regulation by key neurotrophic factors in cultured rat sensory neurones.
Gene_expression (presence) of hIK1 in peripheral nerves
8) Confidence 0.06 Published 2002 Journal Brain Section Abstract Doc Link 11844726 Disease Relevance 0.24 Pain Relevance 0.18

General Comments

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