INT101103

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Context Info
Confidence 0.27
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.25
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (FUT1) Golgi apparatus (FUT1) carbohydrate metabolic process (FUT1)
Anatomy Link Frequency
HSC 4
liver 2
T cell 2
FUT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 4 99.92 Very High Very High Very High
cytokine 49 99.52 Very High Very High Very High
fibrosis 39 99.44 Very High Very High Very High
agonist 54 93.16 High High
alcohol 4 89.48 High High
Inflammation 70 80.00 Quite High
Bile 12 79.92 Quite High
anesthesia 3 57.36 Quite High
Inflammatory response 15 56.72 Quite High
ischemia 4 27.52 Quite Low
Disease Link Frequency Relevance Heat
Cirrhosis 295 100.00 Very High Very High Very High
Injury 34 98.12 Very High Very High Very High
Fibrosis 40 96.80 Very High Very High Very High
Liver Disease 8 85.20 High High
Biliary Liver Cirrhosis 4 83.76 Quite High
INFLAMMATION 84 80.00 Quite High
Hepatotoxicity 3 76.72 Quite High
Endotoxemia 2 74.44 Quite High
Alcoholic Liver Diseases 2 73.92 Quite High
Disease 22 70.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PCLS were treated with thioacetamide or acetaminophen to induce HSC activation.
Positive_regulation (induce) of Positive_regulation (activation) of HSC in HSC associated with paracetamol and cirrhosis
1) Confidence 0.27 Published 2007 Journal Virchows Arch. Section Abstract Doc Link 17431675 Disease Relevance 0.46 Pain Relevance 0.21
The expression of these M6P/IGFII receptors increases as a result of HSC activation during liver fibrosis (11) enabling selective accumulation of M6PHSA in HSC of fibrotic rats (4).
Positive_regulation (increases) of Positive_regulation (activation) of HSC in liver associated with fibrosis and cirrhosis
2) Confidence 0.17 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 1.25 Pain Relevance 0.09
However, inhibition by polyinosinic acid, as found in our studies, suggests that not scavenger receptor class B, but rather class A contributed to the accumulation of M6PHSA conjugates in the HSC.
Neg (not) Positive_regulation (contributed) of Positive_regulation (accumulation) of HSC associated with cirrhosis
3) Confidence 0.13 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.81 Pain Relevance 0
Furthermore, cytokine and oxidant production lead to T cell recruitment, HSC activation and collagen production in the liver of patients with alcoholic steatohepatitis [103].
Positive_regulation (lead) of Positive_regulation (activation) of HSC in T cell associated with cytokine
4) Confidence 0.04 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.26 Pain Relevance 0.49
Ex vivo liver perfusion induces: 1) an early activation of HSC which acquire the expression of alpha-SM actin, and 2) significant changes in the perisinusoidal extracellular matrix.
Positive_regulation (induces) of Positive_regulation (activation) of HSC in HSC associated with cirrhosis
5) Confidence 0.04 Published 2001 Journal J. Submicrosc. Cytol. Pathol. Section Abstract Doc Link 11846091 Disease Relevance 0.46 Pain Relevance 0.06

General Comments

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