INT101105

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Context Info
Confidence 0.30
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 62
Total Number 64
Disease Relevance 55.96
Pain Relevance 9.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (FUT1) Golgi apparatus (FUT1) carbohydrate metabolic process (FUT1)
Anatomy Link Frequency
HSC 8
liver 5
kidney 5
Kupffer cells 3
smooth muscle 2
FUT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 102 99.92 Very High Very High Very High
fibrosis 723 99.90 Very High Very High Very High
Paracetamol 16 99.78 Very High Very High Very High
cytokine 290 99.56 Very High Very High Very High
chemokine 82 99.16 Very High Very High Very High
alcohol 351 98.48 Very High Very High Very High
anesthesia 26 96.92 Very High Very High Very High
Inflammation 829 96.28 Very High Very High Very High
isoflurane 13 96.20 Very High Very High Very High
ischemia 52 96.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cirrhosis 2615 100.00 Very High Very High Very High
Death 267 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 188 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 17 99.98 Very High Very High Very High
Apoptosis 507 99.96 Very High Very High Very High
Injury 710 99.92 Very High Very High Very High
Fibrosis 689 99.90 Very High Very High Very High
Stress 542 99.90 Very High Very High Very High
Alcoholic Hepatitis 84 99.76 Very High Very High Very High
INFLAMMATION 919 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In PCLS culture, both were able to trigger centrolobular lesion and HSC activation as observed in vivo.
Positive_regulation (activation) of HSC in HSC associated with cirrhosis
1) Confidence 0.30 Published 2007 Journal Virchows Arch. Section Abstract Doc Link 17431675 Disease Relevance 0.52 Pain Relevance 0.24
PCLS were treated with thioacetamide or acetaminophen to induce HSC activation.
Positive_regulation (activation) of HSC in HSC associated with paracetamol and cirrhosis
2) Confidence 0.27 Published 2007 Journal Virchows Arch. Section Abstract Doc Link 17431675 Disease Relevance 0.46 Pain Relevance 0.21
In contrast to quiescent HSC, activated HSC lack cytoplasmic lipid droplets containing retinyl esters and long cytoplasmic processes.
Positive_regulation (activated) of HSC in lipid droplets associated with cirrhosis
3) Confidence 0.23 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.29 Pain Relevance 0.03
The expression of these M6P/IGFII receptors increases as a result of HSC activation during liver fibrosis (11) enabling selective accumulation of M6PHSA in HSC of fibrotic rats (4).
Positive_regulation (activation) of HSC in liver associated with fibrosis and cirrhosis
4) Confidence 0.23 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 1.19 Pain Relevance 0.09
Morphinone dose-dependently activated caspase-3 in both HL-60 and HSC-2 cell lines, but to a much lesser extent than actinomycin D.
Positive_regulation (activated) of HSC-2 in HL-60
5) Confidence 0.20 Published 2006 Journal Anticancer Res. Section Abstract Doc Link 17094451 Disease Relevance 0.85 Pain Relevance 0.14
Fig. 2Effect of different 15dPGJ2 forms on the viability of isolated activated HSC.
Positive_regulation (activated) of HSC associated with cirrhosis
6) Confidence 0.20 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.50 Pain Relevance 0
However, inhibition by polyinosinic acid, as found in our studies, suggests that not scavenger receptor class B, but rather class A contributed to the accumulation of M6PHSA conjugates in the HSC.
Positive_regulation (accumulation) of HSC associated with cirrhosis
7) Confidence 0.20 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.81 Pain Relevance 0
receptor is highly upregulated on activated HSC (12,13).
Positive_regulation (upregulated) of HSC associated with cirrhosis
8) Confidence 0.20 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 1.61 Pain Relevance 0.13
With regard to an expected low HSC accumulation of 15dPGJ2in vivo, we now demonstrate a rather complete targeting to the fibrotic liver of both 15dPGJ2 conjugated forms.
Positive_regulation (accumulation) of HSC in liver associated with cirrhosis
9) Confidence 0.20 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.68 Pain Relevance 0.03
Indeed, HSC and PSC are activated by common cytokines, growth factors and alcohol metabolites during development of tissue fibrosis [3,7,30,48-50].
Positive_regulation (activated) of HSC associated with fibrosis, cirrhosis, primary sclerosing cholangitis, alcohol and cytokine
10) Confidence 0.18 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 2.03 Pain Relevance 0.24
We have previously shown that, compared to the primary tumor, liver metastasis of PDAC elicit a weaker fibrogenic response in the HSC that surround them.
Positive_regulation (response) of HSC in liver associated with adenocarcinoma, cirrhosis, cancer and metastasis
11) Confidence 0.17 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 2.47 Pain Relevance 0.21
Vascular cell adhesion molecule 1 (VCAM1) was 5.05-fold upregulated in HSC compared to PSC and chemokine (C-C motif) ligand 2 (CCL2) was 2.96-fold upregulated in HSC compared to PSC.
Positive_regulation (upregulated) of HSC associated with chemokine, cirrhosis, primary sclerosing cholangitis and adhesions
12) Confidence 0.16 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.42 Pain Relevance 0.05
Vascular cell adhesion molecule 1 (VCAM1) was 5.05-fold upregulated in HSC compared to PSC and chemokine (C-C motif) ligand 2 (CCL2) was 2.96-fold upregulated in HSC compared to PSC.
Positive_regulation (upregulated) of HSC associated with chemokine, cirrhosis, primary sclerosing cholangitis and adhesions
13) Confidence 0.16 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.33 Pain Relevance 0.05
In this group, collagen type XI alpha 1 (Col11a1) was the most specific gene with a 13.74-fold upregulation in PSC compared to HSC.
Positive_regulation (upregulation) of HSC associated with cirrhosis and primary sclerosing cholangitis
14) Confidence 0.16 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 0.67 Pain Relevance 0
HSC (day 7 after isolation; 5,000/well) were incubated in a 96-well plate for 24 h in 200 ?
Positive_regulation (incubated) of HSC associated with cirrhosis
15) Confidence 0.15 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.51 Pain Relevance 0
Intrahepatic analysis revealed that 15dPGJ2-M6PHSA mainly accumulated in HSC, and to a lesser extent in Kupffer cells. 15dPGJ2-pPBHSA also predominantly accumulated in HSC with additional uptake in hepatocytes.
Positive_regulation (accumulated) of HSC in Kupffer cells associated with cirrhosis
16) Confidence 0.15 Published 2007 Journal Pharm Res Section Abstract Doc Link PMC1915609 Disease Relevance 1.11 Pain Relevance 0.08
Intrahepatic analysis revealed that 15dPGJ2-M6PHSA mainly accumulated in HSC, and to a lesser extent in Kupffer cells. 15dPGJ2-pPBHSA also predominantly accumulated in HSC with additional uptake in hepatocytes.
Positive_regulation (accumulated) of HSC in Kupffer cells associated with cirrhosis
17) Confidence 0.15 Published 2007 Journal Pharm Res Section Abstract Doc Link PMC1915609 Disease Relevance 1.11 Pain Relevance 0.08
We also determined the intrahepatic localization of both HSC-targeted forms of 15dPGJ2. 15dPGJ2-M6PHSA predominantly accumulated in the HSC (64%) and Kupffer cells (39%).
Positive_regulation (accumulated) of HSC in Kupffer cells associated with cirrhosis
18) Confidence 0.15 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.61 Pain Relevance 0
In contrast, in both groups, there was an increase in exogenous HSC in the ischemic kidney compared to the contralateral kidney, although this was not significant.


Positive_regulation (increase) of HSC in kidney
19) Confidence 0.14 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.05 Pain Relevance 0
As depicted in Figure 3A, the medium supplemented with recSDF-1 resulted in an 8-fold increase of HSC migration compared to the medium alone.
Positive_regulation (increase) of HSC
20) Confidence 0.14 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.21 Pain Relevance 0.07

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