INT101107

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.13
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Anatomy Link Frequency
spinal cord 2
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 2 98.88 Very High Very High Very High
Spinal cord 2 97.68 Very High Very High Very High
Pain 11 96.24 Very High Very High Very High
IPN 1 85.44 High High
adenocard 1 81.52 Quite High
Opioid 1 80.64 Quite High
Kinase C 1 73.76 Quite High
Lasting pain 1 73.56 Quite High
cINOD 1 69.52 Quite High
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 16 99.76 Very High Very High Very High
Stress 10 98.92 Very High Very High Very High
Pain 10 96.24 Very High Very High Very High
Death 2 95.12 Very High Very High Very High
Starvation 1 89.08 High High
Inflammatory Pain 1 85.44 High High
Hepatotoxicity- Drug-induced 1 76.08 Quite High
Hepatotoxicity 1 71.48 Quite High
INFLAMMATION 1 69.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nimesulide exposure increased intracellular ROS, translocation of Bax and Bcl2 followed by mitochondrial depolarization and cytochrome c (Cyt c) release along with caspase-9/-3 activity confirming involvement of mitochondria in nimesulide induced apoptosis.
Positive_regulation (increased) of Localization (translocation) of Bcl2 associated with apoptosis
1) Confidence 0.48 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19772912 Disease Relevance 0.75 Pain Relevance 0.07
These results showed an increased ratio of Bax/Bcl-2 and activated caspase-3 in hippocampus and dorsal lumbar spinal cord of animals treated with pain and IMO stress; these effects were reduced in ADX animals.
Positive_regulation (increased) of Localization (ratio) of Bcl-2 in spinal cord associated with stress, pain, hippocampus and spinal cord
2) Confidence 0.42 Published 2008 Journal Neuroscience Section Abstract Doc Link 18822355 Disease Relevance 1.75 Pain Relevance 1.05
Preconditioning was found to target specifically the mitochondrial control of apoptosis in EC with increased protein levels of Bcl-2, decreased protein levels of Bax, and decreased cytosolic release of cytochrome c.
Positive_regulation (increased) of Localization (release) of Bcl-2 associated with apoptosis
3) Confidence 0.04 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11846399 Disease Relevance 0.62 Pain Relevance 0.16

General Comments

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