INT101108

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Context Info
Confidence 0.72
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 11.68
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Anatomy Link Frequency
spinal cord 1
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 2 98.88 Very High Very High Very High
anesthesia 5 98.00 Very High Very High Very High
Spinal cord 2 97.68 Very High Very High Very High
Pain 16 96.24 Very High Very High Very High
ischemia 125 91.88 High High
IPN 1 85.04 High High
cytokine 22 82.72 Quite High
adenocard 1 81.52 Quite High
imagery 9 80.96 Quite High
Opioid 1 80.64 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 348 100.00 Very High Very High Very High
Follicular Lymphoma 12 99.48 Very High Very High Very High
Lymphatic System Cancer 253 99.04 Very High Very High Very High
Stress 42 98.52 Very High Very High Very High
Glycogen Storage Disease Type Vi 3 98.24 Very High Very High Very High
Overdose 4 97.44 Very High Very High Very High
Pain 11 96.24 Very High Very High Very High
Myocardial Infarction 28 95.84 Very High Very High Very High
Injury 105 95.80 Very High Very High Very High
Malignant Neoplastic Disease 9 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nimesulide exposure increased intracellular ROS, translocation of Bax and Bcl2 followed by mitochondrial depolarization and cytochrome c (Cyt c) release along with caspase-9/-3 activity confirming involvement of mitochondria in nimesulide induced apoptosis.
Localization (translocation) of Bcl2 associated with apoptosis
1) Confidence 0.72 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19772912 Disease Relevance 0.74 Pain Relevance 0.07
These results showed an increased ratio of Bax/Bcl-2 and activated caspase-3 in hippocampus and dorsal lumbar spinal cord of animals treated with pain and IMO stress; these effects were reduced in ADX animals.
Localization (ratio) of Bcl-2 in spinal cord associated with stress, pain, hippocampus and spinal cord
2) Confidence 0.63 Published 2008 Journal Neuroscience Section Abstract Doc Link 18822355 Disease Relevance 1.75 Pain Relevance 1.05
In addition, some markers of apoptosis were slightly affected (Bak, Caspase 7), while most (including Apaf, Caspase 9, caspase 3, caspase 2, Bcl2 and Bad) were not affected by FOS.


Localization (including) of Bcl2 associated with apoptosis
3) Confidence 0.39 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2311291 Disease Relevance 0.32 Pain Relevance 0
Briefly, 4–6 micron thick fixed paraffin tissue sections were subjected to the following immunohistochemical procedure for the localization of Bax and Bcl-2 proteins using specific mouse monoclonal primary antibodies.
Localization (localization) of Bcl-2
4) Confidence 0.35 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1397864 Disease Relevance 0.46 Pain Relevance 0.14
The relative involvement of apoptosis in cardiac I-R was evaluated and the anti-apoptotic activity of these herbs was investigated using immunohistochemical localization of Bax and Bcl-2 proteins and TUNEL staining.
Localization (localization) of Bcl-2 associated with apoptosis
5) Confidence 0.35 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1397864 Disease Relevance 0.75 Pain Relevance 0.03
i) Immunostaining for the localization of Bax and Bcl-2 proteins
Localization (localization) of Bcl-2
6) Confidence 0.35 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1397864 Disease Relevance 0.53 Pain Relevance 0.18
In the present study, TUNEL positivity and the immunohistochemical localization of Bax, an inducer of apoptosis and Bcl-2 proteins, inhibitors of apoptosis were studied to delineate the involvement of apoptosis in I-R induced injury.
Localization (localization) of Bcl-2 associated with injury and apoptosis
7) Confidence 0.31 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1397864 Disease Relevance 1.74 Pain Relevance 0.05
The following primary antibodies were used: rabbit anti-ERK, mouse anti-phospho ERK, mouse anti-Bcl-2, rabbit anti-Bax (Assay Designs, Ann Arbor, MI, USA), mouse anti-SERCA2a, mouse anti-NCX (Affinity Bioreagents, Rockford, IL, USA), and mouse anti-?
Localization (used) of Bcl-2
8) Confidence 0.27 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.12 Pain Relevance 0
The following primary antibodies were used: rabbit anti-ERK, mouse anti-phospho ERK, mouse anti-Bcl-2, rabbit anti-Bax (Assay Designs, Ann Arbor, MI, USA), mouse anti-SERCA2a, mouse anti-NCX (Affinity Bioreagents, Rockford, IL, USA), and mouse anti-?
Localization (anti) of Bcl-2
9) Confidence 0.27 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.12 Pain Relevance 0
Protein levels were visualized by incubation with the following antibodies: bcl-2, caspase-3, ICAM-1, HO-1, NF-?
Localization (visualized) of bcl-2
10) Confidence 0.13 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.12 Pain Relevance 0.08
BCL-2 and BCL-6 immunopositivity and t(14, 18) translocation confirmed a follicular lymphoma.
Localization (translocation) of BCL-2 associated with follicular lymphoma
11) Confidence 0.12 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2905343 Disease Relevance 1.77 Pain Relevance 0.10
Preconditioning was found to target specifically the mitochondrial control of apoptosis in EC with increased protein levels of Bcl-2, decreased protein levels of Bax, and decreased cytosolic release of cytochrome c.
Localization (release) of Bcl-2 associated with apoptosis
12) Confidence 0.05 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11846399 Disease Relevance 0.62 Pain Relevance 0.16
Gene locus translocations of myc, IgH, and bcl-2 were confirmed by FISH analysis in the second case.
Localization (translocations) of bcl-2
13) Confidence 0.05 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904237 Disease Relevance 0.64 Pain Relevance 0
Dual translocations of t(8;14) and t(14;18) involving c-myc and bcl-2 have been reported in Burkitt-like lymphoma patients [9-12]. 13 such patients with the dual translocation were found to have rapid clinical course and extremely poor prognosis [9].
Localization (translocations) of bcl-2 associated with lymphatic system cancer
14) Confidence 0.04 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904237 Disease Relevance 0.82 Pain Relevance 0
Dual translocation of t(8;14) (c-myc) and t(14;18) (bcl-2) was reported to be associated with extremely poor prognosis.
Localization (translocation) of bcl-2
15) Confidence 0.04 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC1904237 Disease Relevance 0.44 Pain Relevance 0
PCR and microdissection have also been used for the detection of the t(14; 18) translocation (ie, translocation between the genes for BCL-2 and IgH) (Shen et al 1998; Wallace at al 2006).
Localization (translocation) of BCL-2
16) Confidence 0.03 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701132 Disease Relevance 0.73 Pain Relevance 0

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