INT101147

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Context Info
Confidence 0.76
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 14.73
Pain Relevance 13.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Uchl1) intracellular (Uchl1) ligase activity (Uchl1)
response to stress (Uchl1) cytoplasm (Uchl1) cell proliferation (Uchl1)
Anatomy Link Frequency
neurons 12
medulla 4
nerve 4
retina 2
dorsal horn 2
Uchl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 901 100.00 Very High Very High Very High
Nerve growth factor 545 100.00 Very High Very High Very High
trk B 153 100.00 Very High Very High Very High
Rostral ventrolateral medulla 24 99.84 Very High Very High Very High
trigeminal ganglion 459 99.52 Very High Very High Very High
medulla 12 99.12 Very High Very High Very High
allodynia 4 99.12 Very High Very High Very High
Hyperalgesia 18 98.56 Very High Very High Very High
anesthesia 33 98.42 Very High Very High Very High
Neuropeptide 306 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ocular Hypertension 450 99.78 Very High Very High Very High
Neuropathic Pain 26 99.72 Very High Very High Very High
Ganglion Cysts 597 99.52 Very High Very High Very High
Cancer 8 98.96 Very High Very High Very High
Apoptosis 13 98.84 Very High Very High Very High
Hyperalgesia 20 98.56 Very High Very High Very High
Poisoning 13 97.80 Very High Very High Very High
Pressure Volume 2 Under Development 4 97.44 Very High Very High Very High
Recurrence 1 97.36 Very High Very High Very High
Neurodegenerative Disease 30 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that de novo synthesis of UCH-L1, leading to an enhanced disassembly of ubiquitin-protein conjugates in the RVLM, is essential to maintenance of the "pro-life" phase of Mev intoxication via prevention of cardiovascular depression, leading to neuroprotection.
Gene_expression (synthesis) of UCH-L1 in RVLM associated with rostral ventrolateral medulla, depression, cardiovascular disorder under development and poisoning
1) Confidence 0.76 Published 2004 Journal Shock Section Abstract Doc Link 15545831 Disease Relevance 0.50 Pain Relevance 0.46
In Sprague-Dawley rats maintained under propofol anesthesia, Mev (960 microg/kg, i.v.) induced a parallel and progressive augmentation in UCH-L1 or ubiquitin expression at the ventrolateral medulla during the course of Mev intoxication.
Gene_expression (expression) of UCH-L1 in medulla associated with medulla, anesthesia and poisoning
2) Confidence 0.76 Published 2004 Journal Shock Section Abstract Doc Link 15545831 Disease Relevance 0.27 Pain Relevance 0.42
In Sprague-Dawley rats maintained under propofol anesthesia, Mev (960 microg/kg, i.v.) induced a parallel and progressive augmentation in UCH-L1 or ubiquitin expression at the ventrolateral medulla during the course of Mev intoxication.
Gene_expression (expression) of UCH-L1 in medulla associated with medulla, anesthesia and poisoning
3) Confidence 0.66 Published 2004 Journal Shock Section Abstract Doc Link 15545831 Disease Relevance 0.27 Pain Relevance 0.42
De novo synthesis of ubiquitin carboxyl-terminal hydrolase isozyme l1 in rostral ventrolateral medulla is crucial to survival during mevinphos intoxication.
Gene_expression (synthesis) of hydrolase isozyme l1 in medulla associated with rostral ventrolateral medulla and poisoning
4) Confidence 0.52 Published 2004 Journal Shock Section Title Doc Link 15545831 Disease Relevance 0.24 Pain Relevance 0.34
The current finding that UCH-L1 mRNA levels are decreased with elevated IOP (Figure 10) is consistent with the findings in other neurodegenerative diseases.
Gene_expression (levels) of UCH-L1 mRNA associated with neurodegenerative disease and ocular hypertension
5) Confidence 0.34 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.16 Pain Relevance 0
Real-time analyses of AQP4/UCH-L1/?
Gene_expression (/) of UCH-L1
6) Confidence 0.34 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0 Pain Relevance 0
Elevated IOP decreased UCH-L1 mRNA levels in the retina, and this may also explain the increased ubiquitination in retina.
Gene_expression (levels) of UCH-L1 mRNA in retina associated with ocular hypertension
7) Confidence 0.34 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.45 Pain Relevance 0.03
In addition, ubiquitin hydrolase L1 (UCH-L1) activity and expression has been shown to correlate with axonal degeneration.
Gene_expression (expression) of UCH-L1
8) Confidence 0.30 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.39 Pain Relevance 0.06
Elevated IOP attenuated expression of UCH-L1 in retina as judged by Q-PCR (8 out 10 rats, 68±8%, p<0.005, Figure 10).
Gene_expression (expression) of UCH-L1 in retina associated with ocular hypertension
9) Confidence 0.30 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.54 Pain Relevance 0
In addition, ubiquitin hydrolase L1 (UCH-L1) activity and expression has been shown to correlate with axonal degeneration.
Gene_expression (expression) of ubiquitin hydrolase L1
10) Confidence 0.30 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.41 Pain Relevance 0.07
The NK1-R/PGP-9.5, BDGF/PGP-9.5, and TrkB/PGP-9.5 ratios of neurons increased not only in the maxillary nerve region, but also in the mandibular nerve region of the trigeminal ganglion.
Gene_expression (ratios) of PGP-9 in neurons associated with ganglion cysts and trigeminal ganglion
11) Confidence 0.17 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1790972 Disease Relevance 0.81 Pain Relevance 0.70
Furthermore, to confirm the expression of new and old nerve fibers, we conducted immunostaining using GAP-43 and PGP-9.5.
Gene_expression (using) of PGP-9 in nerve
12) Confidence 0.17 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1790972 Disease Relevance 0.10 Pain Relevance 0.39
After tooth extraction, degenerative changes of neurons were not observed in double staining for NK1-R and PGP-9.5 and differential interference contrast images of the maxillary nerve region (Fig. 2a–d).
Gene_expression (staining) of PGP-9 in neurons
13) Confidence 0.17 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1790972 Disease Relevance 0.16 Pain Relevance 0.57
The changes in the proportion of TrkB/PGP-9.5 neurons followed a similar tendency to that for BDNF/PGP-9.5 neurons after extraction.
Gene_expression (neurons) of PGP-9 in neurons associated with nerve growth factor
14) Confidence 0.17 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1790972 Disease Relevance 0 Pain Relevance 0.37
Expression of UCH-L1 (a rat homolog of Aplysia neuronal UCH and of the human UCH-L1, also known as PGP 9.5) and its mRNA were selectively increased within the ipsilateral dorsal horn of neuropathic rats, supporting the idea of a role for the ubiquitin-proteasome system in nociceptive processing.
Gene_expression (Expression) of UCH-L1 in dorsal horn associated with nociception, neuropathic pain and dorsal horn
15) Confidence 0.16 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11850463 Disease Relevance 1.19 Pain Relevance 0.83
Expression of UCH-L1 (a rat homolog of Aplysia neuronal UCH and of the human UCH-L1, also known as PGP 9.5) and its mRNA were selectively increased within the ipsilateral dorsal horn of neuropathic rats, supporting the idea of a role for the ubiquitin-proteasome system in nociceptive processing.
Gene_expression (Expression) of UCH-L1 in dorsal horn associated with nociception, neuropathic pain and dorsal horn
16) Confidence 0.16 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11850463 Disease Relevance 1.17 Pain Relevance 0.82
The changes in the proportion of TrkB/PGP-9.5 neurons followed a similar tendency to that for BDNF/PGP-9.5 neurons after extraction.
Gene_expression (neurons) of PGP-9 in neurons associated with nerve growth factor
17) Confidence 0.15 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1790972 Disease Relevance 0 Pain Relevance 0.36
At 7, 14, and 21 days, the proportions of Trk B/PGP-9.5 neurons in both the maxillary and mandibular nerve regions had decreased to the control levels (Fig. 3e, f).


Gene_expression (neurons) of PGP-9 in nerve associated with trk b
18) Confidence 0.15 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1790972 Disease Relevance 0.07 Pain Relevance 0.42
The NK1-R/PGP-9.5, BDGF/PGP-9.5, and TrkB/PGP-9.5 ratios of neurons increased not only in the maxillary nerve region, but also in the mandibular nerve region of the trigeminal ganglion.
Gene_expression (ratios) of PGP-9 in neurons associated with ganglion cysts and trigeminal ganglion
19) Confidence 0.15 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1790972 Disease Relevance 0.82 Pain Relevance 0.71
In the control, the proportion of PGP-9.5-immunoreactive neurons containing NK1-R (NK1-R/PGP-9.5 neurons) in the maxillary and mandibular nerve regions was 18.1 and 16.8%, respectively.
Gene_expression (proportion) of PGP-9 in neurons
20) Confidence 0.15 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1790972 Disease Relevance 0.14 Pain Relevance 0.52

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