INT101148

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 6
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 9.61
Pain Relevance 1.80

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endoplasmic reticulum (UCHL1) intracellular (UCHL1) ligase activity (UCHL1)
response to stress (UCHL1) cytoplasm (UCHL1) cell proliferation (UCHL1)
Anatomy Link Frequency
lung 6
descending colon 1
corpuscles 1
eosinophils 1
dorsal horn 1
UCHL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 16 99.90 Very High Very High Very High
allodynia 2 99.12 Very High Very High Very High
Hyperalgesia 4 98.56 Very High Very High Very High
Neuropathic pain 15 98.40 Very High Very High Very High
intrathecal 1 96.00 Very High Very High Very High
Dorsal horn 1 95.52 Very High Very High Very High
Dorsal horn neuron 2 88.96 High High
abdominal pain 15 76.84 Quite High
Inflammation 43 64.72 Quite High
chemokine 8 62.16 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 20 99.72 Very High Very High Very High
Lung Cancer 40 99.60 Very High Very High Very High
Cancer 45 99.12 Very High Very High Very High
Hyperalgesia 5 98.56 Very High Very High Very High
Disease 194 97.72 Very High Very High Very High
Malignant Neoplastic Disease 1 96.80 Very High Very High Very High
Lymphatic System Cancer 4 96.12 Very High Very High Very High
Nociception 3 91.44 High High
Pressure And Volume Under Development 5 84.16 Quite High
Metastasis 1 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of UCH-L1 expression in the H1299 cell line using RNAi had a similar proproliferative effect, suggesting that the UCH-L1 enzymatic activity is antiproliferative and that UCH-L1 expression may be a response to tumor growth.
Gene_expression (expression) of UCH-L1 associated with cancer
1) Confidence 0.70 Published 2003 Journal Chem. Biol. Section Abstract Doc Link 14522054 Disease Relevance 0.67 Pain Relevance 0.06
Two isatin oxime inhibitors increased proliferation of the H1299 lung tumor cell line but had no effect on a lung tumor line that does not express UCH-L1.
Neg (not) Gene_expression (express) of UCH-L1 in lung associated with lung cancer
2) Confidence 0.70 Published 2003 Journal Chem. Biol. Section Abstract Doc Link 14522054 Disease Relevance 0.59 Pain Relevance 0.06
Certain lung tumor-derived cell lines express UCH-L1 but it is not expressed in normal lung tissue, suggesting that this enzyme plays a role in tumor progression, either as a trigger or as a response.
Gene_expression (express) of UCH-L1 in lung associated with lung cancer and cancer
3) Confidence 0.70 Published 2003 Journal Chem. Biol. Section Abstract Doc Link 14522054 Disease Relevance 0.56 Pain Relevance 0.10
Inhibition of UCH-L1 expression in the H1299 cell line using RNAi had a similar proproliferative effect, suggesting that the UCH-L1 enzymatic activity is antiproliferative and that UCH-L1 expression may be a response to tumor growth.
Gene_expression (expression) of UCH-L1 associated with cancer
4) Confidence 0.70 Published 2003 Journal Chem. Biol. Section Abstract Doc Link 14522054 Disease Relevance 0.63 Pain Relevance 0.05
Mutations described for these familial forms of PD, include autosomal dominant mutations of alpha-synuclein gene (PARK1) (Polymeropoulos et al., 1997), uchl1 gene (PARK5) and lrrk2 gene (PARK8) (Funayama et al., 2002) or autosomal recessive mutations of parkin gene (PARK2) (Kitada et al., 1998; Mizuno et al., 2008), pink1 gene (PARK6) (Hatano et al., 2004; Valente et al., 2004a), dj-1 gene (PARK7) (Bonifati et al., 2003) and atp13a2 gene (PARK9) (Ramirez et al., 2006).
Gene_expression (mutations) of PARK5 associated with disease
5) Confidence 0.65 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.97 Pain Relevance 0
Unfixed tissue sections were postfixed in 4% (w/v) paraformaldehyde, whilst tissue sections from immersion fixed biopsies were allowed to dry on the slide (for SP and PGP9.5 antibodies only).
Gene_expression (antibodies) of PGP9.5 associated with substance p
6) Confidence 0.65 Published 2008 Journal Gut Section Body Doc Link PMC2564830 Disease Relevance 0.06 Pain Relevance 0.12
Two isatin oxime inhibitors increased proliferation of the H1299 lung tumor cell line but had no effect on a lung tumor line that does not express UCH-L1.
Neg (not) Gene_expression (express) of UCH-L1 in lung associated with lung cancer
7) Confidence 0.60 Published 2003 Journal Chem. Biol. Section Abstract Doc Link 14522054 Disease Relevance 0.59 Pain Relevance 0.06
Certain lung tumor-derived cell lines express UCH-L1 but it is not expressed in normal lung tissue, suggesting that this enzyme plays a role in tumor progression, either as a trigger or as a response.
Gene_expression (express) of UCH-L1 in lung associated with lung cancer and cancer
8) Confidence 0.60 Published 2003 Journal Chem. Biol. Section Abstract Doc Link 14522054 Disease Relevance 0.56 Pain Relevance 0.10
Inhibition of UCH-L1 expression in the H1299 cell line using RNAi had a similar proproliferative effect, suggesting that the UCH-L1 enzymatic activity is antiproliferative and that UCH-L1 expression may be a response to tumor growth.
Gene_expression (expression) of UCH-L1 associated with cancer
9) Confidence 0.60 Published 2003 Journal Chem. Biol. Section Abstract Doc Link 14522054 Disease Relevance 0.63 Pain Relevance 0.05
Inhibition of UCH-L1 expression in the H1299 cell line using RNAi had a similar proproliferative effect, suggesting that the UCH-L1 enzymatic activity is antiproliferative and that UCH-L1 expression may be a response to tumor growth.
Gene_expression (expression) of UCH-L1 associated with cancer
10) Confidence 0.60 Published 2003 Journal Chem. Biol. Section Abstract Doc Link 14522054 Disease Relevance 0.67 Pain Relevance 0.06
Certain lung tumor-derived cell lines express UCH-L1 but it is not expressed in normal lung tissue, suggesting that this enzyme plays a role in tumor progression, either as a trigger or as a response.
Gene_expression (express) of UCH-L1 in lung associated with lung cancer and cancer
11) Confidence 0.60 Published 2003 Journal Chem. Biol. Section Abstract Doc Link 14522054 Disease Relevance 0.56 Pain Relevance 0.10
Certain lung tumor-derived cell lines express UCH-L1 but it is not expressed in normal lung tissue, suggesting that this enzyme plays a role in tumor progression, either as a trigger or as a response.
Neg (not) Gene_expression (expressed) of UCH-L1 in lung associated with lung cancer and cancer
12) Confidence 0.60 Published 2003 Journal Chem. Biol. Section Abstract Doc Link 14522054 Disease Relevance 0.56 Pain Relevance 0.10
Immunohistochemically, these lymphoid cells were positive for UCHL-1/CD45RO and CD3 and negative for CD79a, indicating that the tumor was a primary malignant T-cell lymphoma of the descending colon.
Neg (negative) Gene_expression (positive) of UCHL-1 in descending colon associated with malignant neoplastic disease, lymphatic system cancer and cancer
13) Confidence 0.57 Published 2004 Journal J. Gastroenterol. Section Abstract Doc Link 15338374 Disease Relevance 1.06 Pain Relevance 0.08
Specifically, the relative non-PGP 9.5 area also containing eosinophils was 2.8 ± 0.65 percent compared to only 0.70 ± 0.60 percent of the relative PGP 9.5 positive area, (P < .03???
Gene_expression (area) of PGP 9.5 in eosinophils
14) Confidence 0.22 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0.03
Specifically, the relative area of PGP 9.5 positive and MBP positive was 7.0 ± 3.0 percent compared to PGP 9.5 negative and MBP positive 5.9 ± 1.3 percent, (P > .7, n = 3 determinations from 10 distinct patients).
Neg (negative) Gene_expression (negative) of PGP 9.5
15) Confidence 0.22 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0
The relative area staining for PGP 9.5 with MBP was not significantly different from the relative area staining positive for MBP not containing PGP 9.5.
Neg (not) Gene_expression (containing) of PGP 9.5
16) Confidence 0.22 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0
Specifically, the relative area of PGP 9.5 positive and MBP positive was 7.0 ± 3.0 percent compared to PGP 9.5 negative and MBP positive 5.9 ± 1.3 percent, (P > .7, n = 3 determinations from 10 distinct patients).
Gene_expression (positive) of PGP 9.5
17) Confidence 0.22 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0
Thirty-one priority genes have been previously designated PD candidate genes (http://www.pdgene.org/) (SI_Table_1f), and it is worth noting that 33 are considered AD candidate genes as well (SI_Table_1g) with HSPA1A, HSPA1B, HTR2A, KCNJ6, SLC6A3, SNCA, SNCG, TF and UCHL1 being present in both lists.
Gene_expression (present) of UCHL1 associated with disease
18) Confidence 0.18 Published 2008 Journal Neurogenetics Section Body Doc Link PMC2238789 Disease Relevance 0.32 Pain Relevance 0
The axons of the corpuscles, including those within the small corpuscular structures, exhibited marked PGP 9.5 immunoreaction.
Gene_expression (immunoreaction) of PGP 9.5 in corpuscles
19) Confidence 0.09 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1569833 Disease Relevance 0 Pain Relevance 0
Expression of UCH-L1 (a rat homolog of Aplysia neuronal UCH and of the human UCH-L1, also known as PGP 9.5) and its mRNA were selectively increased within the ipsilateral dorsal horn of neuropathic rats, supporting the idea of a role for the ubiquitin-proteasome system in nociceptive processing.
Gene_expression (Expression) of UCH in dorsal horn associated with nociception, neuropathic pain and dorsal horn
20) Confidence 0.03 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11850463 Disease Relevance 1.18 Pain Relevance 0.83

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