INT10115

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Context Info
Confidence 0.75
First Reported 1984
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 31
Total Number 35
Disease Relevance 11.98
Pain Relevance 4.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INSR) endosome (INSR) plasma membrane (INSR)
nucleus (INSR) carbohydrate metabolic process (INSR)
Anatomy Link Frequency
plasma 3
amniotic fluid 2
nerve 2
impression 1
posterior 1
INSR (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 12 100.00 Very High Very High Very High
substance P 11 100.00 Very High Very High Very High
Inflammation 96 99.80 Very High Very High Very High
bradykinin 22 99.80 Very High Very High Very High
Bile 3 98.08 Very High Very High Very High
qutenza 25 96.36 Very High Very High Very High
antagonist 23 92.24 High High
Dynorphin 7 91.32 High High
opiate 6 90.72 High High
cytokine 37 89.04 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 69 100.00 Very High Very High Very High
Reperfusion Injury 64 100.00 Very High Very High Very High
Insulin Resistance 47 100.00 Very High Very High Very High
Targeted Disruption 31 100.00 Very High Very High Very High
Hyperinsulinism 3 100.00 Very High Very High Very High
INFLAMMATION 122 99.80 Very High Very High Very High
Obesity 369 99.68 Very High Very High Very High
Ganglion Cysts 3 99.58 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 41 99.34 Very High Very High Very High
Apoptosis 45 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: The regulatory mechanisms of PP-mediated hepatic IR expression and combined IR and GLUT2 endocytosis after insulin binding are defective in chronic pancreatitis and contribute to the apancreatic diabetes, which characterizes this disease.


Gene_expression (expression) of IR
1) Confidence 0.75 Published 2007 Journal Pancreas Section Body Doc Link 17575539 Disease Relevance 0 Pain Relevance 0
Pro and anti-inflammatory molecule expression in B1R knockout or antagonism after renal IRI
Gene_expression (expression) of IRI associated with targeted disruption, reperfusion injury and inflammation
2) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.54 Pain Relevance 0.38
RESULTS: In addition to decreased insulin secretory capacity, pancreatogenic (or apancreatic) diabetes is characterized by decreased or absent glucagon and pancreatic polypeptide (PP) secretion, a loss of hepatic insulin receptor (IR) expression/availability, and an impairment in hepatic IR function (phosphorylation and endocytosis).
Neg (absent) Gene_expression (expression/availability) of IR
3) Confidence 0.65 Published 2007 Journal Pancreas Section Body Doc Link 17575539 Disease Relevance 0 Pain Relevance 0
The levels of SP-IR in the trachea and peripheral bronchi of man were about 3-4 pmol/g, which is in the same range as the content of corresponding tissues from the guinea-pig.
Gene_expression (levels) of SP-IR in trachea associated with substance p
4) Confidence 0.60 Published 1984 Journal Cell Tissue Res. Section Abstract Doc Link 6200231 Disease Relevance 0.08 Pain Relevance 0.49
Bradykinin receptor expression in renal IRI
Gene_expression (expression) of IRI associated with reperfusion injury and bradykinin
5) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.25 Pain Relevance 0.19
The FCs observed for a subset of the genes have been confirmed with additional qRT-PCR results (Table 2 and Table 3)

Protein expression of the Insulin Receptor (IR) and PGC1?

Gene_expression (expression) of Insulin Receptor
6) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0 Pain Relevance 0
These findings are consistent with a pituitary source for the elevated plasma beta E IR found during late pregnancy which may, in turn, be a consequence of elevated plasma concentrations of placentally secreted plasma corticotropin-releasing factor IR present during the third trimester.
Gene_expression (source) of E IR in plasma
7) Confidence 0.48 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1464647 Disease Relevance 0 Pain Relevance 0.09
These findings are consistent with a pituitary source for the elevated plasma beta E IR found during late pregnancy which may, in turn, be a consequence of elevated plasma concentrations of placentally secreted plasma corticotropin-releasing factor IR present during the third trimester.
Gene_expression (present) of factor IR in plasma
8) Confidence 0.48 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1464647 Disease Relevance 0 Pain Relevance 0.08
Total plasma beta E IR rose from 28 weeks gestation (8.5 +/- 0.3 fmol/mL, n = 159) to peak at labor (50 +/- 4 fmol/mL, n = 98; P < 0.01) but total Ac beta E IR was found in only four 28-week (1.7 +/- 0.9 fmol/mL) and 42 labor plasma samples (0.9 +/- 0.1 fmol/mL).
Gene_expression (rose) of E IR in plasma
9) Confidence 0.48 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1464647 Disease Relevance 0 Pain Relevance 0.08
SP-IR and CGRP-IR were also present in the same cells of jugular, nodose and thoracic spinal ganglia but only in nerve fibres in local parasympathetic ganglia and the stellate ganglia, suggesting a sensory origin.
Gene_expression (present) of SP-IR in nerve
10) Confidence 0.22 Published 1987 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 3499054 Disease Relevance 0.17 Pain Relevance 0.16
The rate of improvement according to the psychiatrist rated clinical global impression (CGI-I) for ADHD was statistically significantly higher for both IR-MPH (tid) (?
Gene_expression (higher) of IR-MPH in impression associated with attention deficit hyperactivity disorder
11) Confidence 0.19 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2075491 Disease Relevance 0.10 Pain Relevance 0
At immunohistochemistry, tachykinin- and CGRP-immunoreactivities (TK-IR/CGRP-IR) were detected in varicose nerve fibers throughout the common bile duct, while TK-IR cell bodies were observed in the terminal portion (ampulla) only.
Gene_expression (detected) of TK-IR in terminal portion associated with bile
12) Confidence 0.17 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10543438 Disease Relevance 0 Pain Relevance 0.83
Interestingly, signaling via growth-hormone receptor (GHR), insulin receptor (INSR) and epidermal growth factor receptor was among the top 10 Networks (score ?
Gene_expression (signaling) of insulin receptor
13) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.85 Pain Relevance 0
The levels of irET in amniotic fluid during the midtrimester of human pregnancy, 93.3 +/- 7.4 pmol/L (mean +/- SEM, n = 38), were significantly greater than those in amniotic fluid at term before the onset of labor, 39.8 +/- 4.1 (n = 33, p < 0.01).
Gene_expression (levels) of irET in amniotic fluid
14) Confidence 0.09 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8501173 Disease Relevance 0.17 Pain Relevance 0.17
The levels of irET in the upper compartment during labor, 45.5 +/- 3.5 pmol/L (n = 40), were not significantly different from those in amniotic fluid before labor, but were significantly less (p < 0.01) than those in amniotic fluid of the forebag, 82.1 +/- 5.2 pmol/L (n = 125).
Gene_expression (levels) of irET in amniotic fluid
15) Confidence 0.09 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8501173 Disease Relevance 0.26 Pain Relevance 0.20
Antibodies against CD-34, F-VIII, HHF-35, CK5/6, CD-15, p53 and bcl-2 were negative.
Neg (negative) Gene_expression (negative) of HHF-35
16) Confidence 0.08 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2615039 Disease Relevance 1.13 Pain Relevance 0.07
There was a highly significant correlation between the levels of irET and PGE2 in the forebag compartment (p < 0.0001); there was no correlation between irET and PGE2 levels in the upper compartment or in amniotic fluid collected at term prior to labor onset.
Gene_expression (levels) of irET in upper
17) Confidence 0.07 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8501173 Disease Relevance 0.16 Pain Relevance 0.08
The increased insulin receptor gene expression in women could be related to the higher GRB10 expression (see Discussion).
Gene_expression (expression) of insulin receptor associated with hyperinsulinism
18) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.10 Pain Relevance 0
We further investigated whether there were interactions of GnIH-ir neurons with GnRH neurons by double-label ICC.
Gene_expression (neurons) of GnIH-ir in neurons
19) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791420 Disease Relevance 0 Pain Relevance 0.04
Relative to placebo, indiplon-IR was the only drug that did not produce any significant changes on any of these tests.
Neg (not) Gene_expression (produce) of indiplon-IR
20) Confidence 0.04 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656319 Disease Relevance 0.33 Pain Relevance 0.05

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