INT101166

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Context Info
Confidence 0.15
First Reported 2002
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.66
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
knee joints 2
microglial cells 2
respiratory 2
Cpox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 14 99.88 Very High Very High Very High
aspirin 11 99.76 Very High Very High Very High
COX-2 inhibitor 7 97.96 Very High Very High Very High
ischemia 21 97.64 Very High Very High Very High
dorsal root ganglion 107 97.12 Very High Very High Very High
Inflammation 53 92.56 High High
Arthritis 28 83.40 Quite High
bradykinin 40 75.76 Quite High
b2 receptor 10 72.40 Quite High
Pain 11 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 58 99.48 Very High Very High Very High
Brain Injury 36 99.20 Very High Very High Very High
Respiratory Disease 2 99.20 Very High Very High Very High
Cv Unclassified Under Development 9 97.64 Very High Very High Very High
Ganglion Cysts 107 97.12 Very High Very High Very High
Disease 15 90.52 High High
Sinusitis 2 88.32 High High
Rhinitis 3 87.92 High High
Hyperplasia 1 87.40 High High
Asthma 3 84.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Active research is being conducted to unravel the cellular mechanisms mediating the anti-tumorigenic effects of nonsteroidal anti-inflammatory drugs (NSAIDs) and their association with cyclooxygenase (COX) inhibition.
Negative_regulation (inhibition) of COX Binding (association) of associated with inflammation and cinod
1) Confidence 0.15 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 11853685 Disease Relevance 0.41 Pain Relevance 0.64
Furthermore, co-cultures of DRG neurones and FLS cells from normal or acutely and chronically inflamed knee joints were made in a medium containing either the cyclooxygenase (COX) inhibitor indomethacin (1 ?
Negative_regulation (inhibitor) of COX Binding (indomethacin) of in knee joints associated with dorsal root ganglion
2) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0.46 Pain Relevance 0.43
Furthermore, treatment with COX inhibitors has been proven to significantly reduce IL-1?
Negative_regulation (inhibitors) of COX Binding (treatment) of
3) Confidence 0.07 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.29 Pain Relevance 0.05
Resveratrol effects on mPGES-1 expression seem to be independent on its ability to reduce COX activity/PGE2 formation since other COX inhibitors were unable to modify LPS-induced mPGES-1 upregulation in microglial cells despite their potent inhibitory effects on PGE2 production (Figs. 6 and 7).
Negative_regulation (reduce) of COX Binding (formation) of in microglial cells
4) Confidence 0.07 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0 Pain Relevance 0
Furthermore, treatment with COX inhibitors has been proven to significantly reduce IL-1?
Negative_regulation (reduce) of COX Binding (treatment) of
5) Confidence 0.07 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.29 Pain Relevance 0.05
This review focuses on descriptions of these patients; methods available to diagnose ASA-exacerbated respiratory disease; the unique ability of all NSAIDs that inhibit COX-1 to cross-react with ASA; lack of cross-reactivity with selective COX-2 inhibitors; an update on pathogenesis; and current thoughts about treatment, including ASA desensitization and daily ingestion of ASA itself.
Negative_regulation (inhibit) of COX Neg (lack) Binding (cross-react) of in respiratory associated with aspirin, cinod, cox-2 inhibitor and respiratory disease
6) Confidence 0.03 Published 2009 Journal Curr Allergy Asthma Rep Section Abstract Doc Link 19210906 Disease Relevance 1.20 Pain Relevance 0.62

General Comments

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