INT101168

Context Info Confidence 0.75 First Reported 2002 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 23 Total Number 23 Disease Relevance 10.88 Pain Relevance 5.38

nucleus (Tbpl1) DNA binding (Tbpl1) cytoplasm (Tbpl1)

Anatomy Link Frequency plasma 2 sensory neurons 2 neurons 2 bone marrow 1 brain 1 Tbpl1 (Mus musculus)

Pain Link Frequency Relevance Heat TRP channel 46 100.00 trigeminal ganglion 88 99.60 dorsal root ganglion 110 99.48 c fibre 24 99.32 allodynia 116 99.18 Hippocampus 22 99.10 Neuronal excitability 4 98.52 nociceptor 60 98.20 Enkephalin 3 97.76 opiate 2 97.40

Disease Link Frequency Relevance Heat Nervous System Injury 95 99.92 Hodgkin's Disease 385 99.84 Ganglion Cysts 203 99.60 Neuropathic Pain 261 99.18 Lymphatic System Cancer 125 99.12 Photosensitivity Disorders 5 98.96 Injury 215 98.84 Nociception 97 98.64 Cough 1 97.40 Respiratory Failure 1 97.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

TRPA1 is a member of the transient receptor potential (TRP) channel family expressed in sensory neurons.

Gene_expression (expressed) of TRP in sensory neurons

1) Confidence 0.75 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17825279 Disease Relevance 0 Pain Relevance 0.07

The expression of TRP channels in CHO cells demonstrates that both WIN and AM1241 activate TRPA1 and, by doing so, attenuate capsaicin and mustard oil responses.

Gene_expression (expression) of TRP associated with qutenza and trp channel

2) Confidence 0.75 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18234885 Disease Relevance 0.32 Pain Relevance 0.94

TRPA1, a TRP ion channel expressed in chemosensory C-fibers, is activated by almost all oxidizing and electrophilic chemicals, including chlorine, acrolein, tear gas agents, and methyl isocyanate, the highly noxious chemical released in the Bhopal disaster.

Gene_expression (expressed) of TRP in tear associated with c fibre

3) Confidence 0.75 Published 2010 Journal Proc Am Thorac Soc Section Abstract Doc Link 20601631 Disease Relevance 0.58 Pain Relevance 0.42

After injection of endomorphin-1 (Tyr-Pro-Trp-Phe-NH(2)), endomorphin-2 (Tyr-Pro-Phe-Phe-NH(2)), Met-enkephalin (Tyr-Gly-Gly-Phe-Met-OH), and Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH(2)) into the lateral ventricle of the mouse brain, residual radioactivity was measured at 0, 2, 5, 10, and 20 min later.

Gene_expression (injection) of Trp in brain associated with enkephalin

4) Confidence 0.65 Published 2002 Journal Drug Metab. Dispos. Section Abstract Doc Link 11854138 Disease Relevance 0.16 Pain Relevance 0.48

Since differences in plasma volume, which could partially explain the reduction in plasma free-[Trp] and free-Trp:Tyr ratio were not observed in the present experiment, the exact mechanism(s) responsible for the observed reduction in plasma free-[Trp] and free-Trp:Tyr ratio after Cr loading (despite no difference in plasma [FFA]) and the significance of these observations remain to be determined.

Gene_expression (ratio) of Trp in plasma

5) Confidence 0.36 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2570654 Disease Relevance 0.06 Pain Relevance 0

Since differences in plasma volume, which could partially explain the reduction in plasma free-[Trp] and free-Trp:Tyr ratio were not observed in the present experiment, the exact mechanism(s) responsible for the observed reduction in plasma free-[Trp] and free-Trp:Tyr ratio after Cr loading (despite no difference in plasma [FFA]) and the significance of these observations remain to be determined.

Gene_expression (ratio) of Trp in plasma

6) Confidence 0.36 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2570654 Disease Relevance 0.06 Pain Relevance 0

The pattern of Trp photoproducts formed by the two compounds differs and is specific for each type of sensitization process.

Gene_expression (photoproducts) of Trp

7) Confidence 0.24 Published 2009 Journal Photochem. Photobiol. Sci. Section Abstract Doc Link 19789818 Disease Relevance 0.45 Pain Relevance 0.06

Additionally, in the hippocampus of Tdo-/- mice, the level of 5-HT, which is synthesized from Trp, is 2-fold higher than that in control mice [14].

Gene_expression (synthesized) of Trp in hippocampus associated with hippocampus

8) Confidence 0.19 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0.35 Pain Relevance 0.50

To examine whether this phenotype is recapitulated in vivo, we used TaqMan RT-PCR to look at changes in TRP channel gene expression in mouse TG tissues harvested after 3 weeks treatment with platinum drugs [48].

Gene_expression (expression) of TRP associated with trp channel and trigeminal ganglion

9) Confidence 0.19 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.86 Pain Relevance 0.56

This quantitative approach enabled comparisons of the relative changes in expression of each TRP mRNA in response to platinum drugs at varying time points.

Gene_expression (expression) of TRP mRNA

10) Confidence 0.19 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.53 Pain Relevance 0.33

With prolonged drug exposure, sustained increase of the TRP transcripts expression may result from increased long-term neuronal excitability.

Gene_expression (expression) of TRP in neuronal associated with neuronal excitability

11) Confidence 0.19 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.43 Pain Relevance 0.27

These data demonstrate a time dependent transcriptional modulation of the expression pattern of TRP channels on DRG neurons following exposure to cisplatin.

Gene_expression (expression) of TRP in neurons associated with dorsal root ganglion and trp channel

12) Confidence 0.16 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.42 Pain Relevance 0.27

However, in agreement with our results in mice, we were unable to detect an upregulation in TRP channel expression in either ganglia following injury.

Gene_expression (expression) of TRP in ganglia associated with trp channel and injury

13) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.73 Pain Relevance 0.29

Sensory neurons express a wide variety of TRP channels that are thought to be in some manner, sensitive to mechanical force, including TRPA1, TRPV2, TRPV4, TRPC1, TRPC6 and TRPP2 [4], [26].

Gene_expression (express) of TRP in Sensory neurons associated with trp channel

14) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922334 Disease Relevance 0.14 Pain Relevance 0.16

Our results suggest that cold allodynia does not arise directly from changes in TRP channel expression.

Gene_expression (expression) of TRP associated with trp channel and allodynia

15) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.20 Pain Relevance 0.46

TRP channel expression remains constant for a period of hours after dissociation [29], therefore all experiments were performed within 3 hours of plating cells.

Gene_expression (expression) of TRP associated with trp channel

16) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.57 Pain Relevance 0.27

We now know that thermosensitive afferents express ion channels of the transient receptor potential (TRP) family that respond at distinct temperature thresholds, thus establishing the molecular basis for thermosensation.

Gene_expression (express) of TRP

17) Confidence 0.04 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1087877 Disease Relevance 0.06 Pain Relevance 0.24

The above hypothesis was confirmed by the concurrent cloning of a cold and menthol receptor by two independent groups; one using menthol to expression-clone a cDNA, from rat TG neurons, that could confer menthol-sensitivity in heterologous expression systems [14], and another that used a genomics approach to identify TRP channels expressed in mouse DRG neurons [28].

Gene_expression (expressed) of TRP in neurons associated with trp channel

18) Confidence 0.03 Published 2005 Journal Mol Pain Section Body Doc Link PMC1087877 Disease Relevance 0 Pain Relevance 0.05

The 21 kDa protein overexpressed in HL and aggressive NHL is identical to CYB5B.

Gene_expression (overexpressed) of 21 kDa protein associated with lymphatic system cancer and hodgkin's disease

19) Confidence 0.01 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2829491 Disease Relevance 1.28 Pain Relevance 0

Since we had previously reported that PHA-activated T cells do not express the 21 kDa protein at the cell surface [24], the detection of CYB5B in a PHA-induced T-lymphocyte cDNA library derived protein array may seem like a contradiction.

Neg (not) Gene_expression (express) of 21 kDa protein in T-lymphocyte

20) Confidence 0.01 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.