INT101175

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Context Info
Confidence 0.19
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL4A4)
Anatomy Link Frequency
macrophages 1
plasma 1
COL4A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 32.40 Quite Low
metalloproteinase 16 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 117 81.76 Quite High
Adenocarcinoma 1 72.40 Quite High
Stomach Cancer 27 52.16 Quite High
Pancreatic Cancer 2 50.00 Quite Low
Sarcoma 1 32.20 Quite Low
Syndrome 4 13.52 Low Low
Sprains And Strains 43 5.00 Very Low Very Low Very Low
Leptospirosis 29 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low
Metastasis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a negative control, primary antibody was replaced with Tris-buffered saline on sections that were proven to be positive for MMP9, MMP2, type IV collagen, macrophages and CD105 in preliminary experiments.


Positive_regulation (positive) of IV collagen in macrophages
1) Confidence 0.19 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 0.13 Pain Relevance 0
In contrast, the desmoplastic reaction surrounding all 10 pancreatic adenocarcinoma specimens displayed intense interstitial staining for alpha-SMA, SMMHC, and collagen IV but no staining for von Willebrand factor and cluster of differentiation 31.
Positive_regulation (staining) of collagen IV
2) Confidence 0.14 Published 2002 Journal Surgery Section Body Doc Link 11854689 Disease Relevance 0.07 Pain Relevance 0
For determination of dose-dependent attachment of Lsa21 protein to laminin, collagen IV and plasma fibronectin, protein concentrations varying from 0 to 2,000 nM in PBS were used.
Positive_regulation (attachment) of collagen IV in plasma
3) Confidence 0.01 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2386478 Disease Relevance 0 Pain Relevance 0

General Comments

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