INT101176

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.73
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (VWF) cell adhesion (VWF) endoplasmic reticulum (VWF)
proteinaceous extracellular matrix (VWF)
Anatomy Link Frequency
endothelial cells 2
VWF (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 1 81.60 Quite High
agonist 1 81.60 Quite High
aspirin 7 78.48 Quite High
Inflammation 11 70.44 Quite High
cINOD 2 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 1 94.00 High High
Left Ventricular Hypertrophy 24 89.12 High High
Cv General 3 Under Development 2 81.60 Quite High
Acute Coronary Syndrome 4 80.40 Quite High
Metabolic Disorder 1 75.32 Quite High
Atherosclerotic Plaque 1 74.00 Quite High
Hypertension 4 73.56 Quite High
Adenocarcinoma 1 72.40 Quite High
Insulin Resistance 2 72.20 Quite High
Diabetes Mellitus 1 71.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-B; (3) upregulating angiotensin II type 1 receptor in vascular smooth muscle cells, and directly quenching the production of nitric oxide by endothelial cells [24, 25], resulting in increased production of endothelin-1 [26]; (4) elevation of von Willebrand factor [27], which is known to be associated with endothelial dysfunction.
Positive_regulation (upregulating) of Positive_regulation (elevation) of von Willebrand factor in endothelial cells
1) Confidence 0.49 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2975076 Disease Relevance 1.20 Pain Relevance 0.09
In contrast, the desmoplastic reaction surrounding all 10 pancreatic adenocarcinoma specimens displayed intense interstitial staining for alpha-SMA, SMMHC, and collagen IV but no staining for von Willebrand factor and cluster of differentiation 31.
Positive_regulation (staining) of Neg (no) Positive_regulation (staining) of von Willebrand factor
2) Confidence 0.34 Published 2002 Journal Surgery Section Body Doc Link 11854689 Disease Relevance 0.07 Pain Relevance 0
Activation of the GPIb von Willebrand factor receptor with ristocetin did not stimulate p38 MAPK.
Neg (not) Positive_regulation (stimulate) of Positive_regulation (Activation) of GPIb von Willebrand factor receptor
3) Confidence 0.14 Published 2004 Journal Thromb. Haemost. Section Abstract Doc Link 15583748 Disease Relevance 0.46 Pain Relevance 0.22

General Comments

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