INT101177

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 4.03
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL5A2) molecular_function (COL5A2)
Anatomy Link Frequency
epidermal cells 1
cartilage 1
stellate cells 1
cornea 1
COL5A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 37 98.00 Very High Very High Very High
Inflammation 46 94.48 High High
fibrosis 4 89.68 High High
Chronic pancreatitis 1 88.72 High High
Osteoarthritis 54 86.48 High High
Arthritis 3 55.68 Quite High
Pain 19 53.32 Quite High
metalloproteinase 5 37.72 Quite Low
imagery 21 5.00 Very Low Very Low Very Low
cytokine 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 2 99.88 Very High Very High Very High
Hepatocellular Cancer 1 99.04 Very High Very High Very High
Rheumatoid Arthritis 61 98.00 Very High Very High Very High
Uterine Fibroids 120 96.16 Very High Very High Very High
Pancreatic Cancer 2 96.08 Very High Very High Very High
INFLAMMATION 55 94.48 High High
Intervertebral Disk Degeneration 39 92.56 High High
Fibrosis 2 89.68 High High
Pancreatitis 1 88.72 High High
Wound Healing 45 87.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We believe that in the anterior labrum the marginal attachment and the orientation of the collagen fibres parallel to the labral-chondral junction may render it more prone to damage than the posterior labrum in which the collagen fibres are anchored in the acetabular cartilage.
Regulation (anchored) of collagen in cartilage
1) Confidence 0.45 Published 2008 Journal J Bone Joint Surg Br Section Abstract Doc Link 18669956 Disease Relevance 0.11 Pain Relevance 0.08
Some members of this family are known to regulate collagen fibrillogenesis [10].
Regulation (regulate) of collagen
2) Confidence 0.23 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533033 Disease Relevance 0 Pain Relevance 0
It was shown that synthesis of nonglycosylated decorin in avian cornea leads to disruption in lamellar organization, suggesting that dermatan sulfate proteoglycans are not involved in the regulation of collagen fibril diameter, but are important to fibril-fibril spacing and lamellar cohesiveness [21].
Regulation (regulation) of collagen in cornea
3) Confidence 0.23 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533033 Disease Relevance 0 Pain Relevance 0
M) alone, inhibited basal contraction; a 23% increase (P < 0.001) in gel area was observed in comparison to control hUtSMC embedded collagen gels, 2.5 hours after its addition (Figure 2B).


Regulation (control) of collagen
4) Confidence 0.17 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
Hepatic stellate cells, which activate to a myofibroblast-like form, are responsible for collagen deposition in cirrhosis and around hepatocellular carcinomas.
Regulation (responsible) of collagen in stellate cells associated with cirrhosis and hepatocellular cancer
5) Confidence 0.11 Published 2002 Journal Surgery Section Abstract Doc Link 11854689 Disease Relevance 0.65 Pain Relevance 0.13
The ability to isolate total RNA from the collagen cell matrix represents a chance to gain a unique insight into gene expression changes as a result of alterations in collagen contractility.
Regulation (alterations) of collagen
6) Confidence 0.10 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
Its biological function is still unclear, but findings suggest that COMP may be involved in regulating fibril formation and maintaining the integrity of the collagen network.
Regulation (integrity) of collagen
7) Confidence 0.04 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0.61 Pain Relevance 0.15
Mann found that presence of the T allele in the COLIA1 Sp1 binding site has functional effects on the collagen gene regulation that leads to a higher COLIA1 mRNA expression level, an increase COLIA1 protein expression level and COLIA1/COLIA2 protein ratios 25.
Regulation (regulation) of collagen
8) Confidence 0.04 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.76 Pain Relevance 0
With ATRA treatment, a down-regulation of collagen genes was observed.
Regulation (regulation) of collagen
9) Confidence 0.03 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.73 Pain Relevance 0
We further show that NFAT5 contributes to the differential regulation of both collagen types.
Regulation (regulation) of collagen
10) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.45 Pain Relevance 0.15
Rice et al106 and Lindsay and Rice97 suggested that following exposure to HD, papillary dermal collagen is altered and may no longer function normally as a healthy scaffold over which epidermal cells can migrate.
Regulation (altered) of collagen in epidermal cells
11) Confidence 0.01 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0.54 Pain Relevance 0
Resveratrol affected AGEs-regulated MMP-13 expression and activity and collagen II level
Regulation (affected) of collagen
12) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2990994 Disease Relevance 0.19 Pain Relevance 0.10

General Comments

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