INT10118

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 15
Total Number 17
Disease Relevance 0.77
Pain Relevance 19.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdyn) plasma membrane (Pdyn)
Anatomy Link Frequency
substantia nigra 8
nucleus accumbens 4
spinal cord 4
neuronal 2
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 192 100.00 Very High Very High Very High
Nucleus accumbens 126 100.00 Very High Very High Very High
Dynorphin 85 100.00 Very High Very High Very High
Spinal cord 10 100.00 Very High Very High Very High
electroacupuncture 62 99.98 Very High Very High Very High
Opioid 26 99.84 Very High Very High Very High
Cannabinoid 18 99.76 Very High Very High Very High
Morphine 93 99.68 Very High Very High Very High
Substantia nigra 25 99.68 Very High Very High Very High
antinociception 18 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Opiate Addiction 20 95.52 Very High Very High Very High
Substance Withdrawal Syndrome 2 79.16 Quite High
Convulsion 2 77.28 Quite High
Drug Dependence 48 5.00 Very Low Very Low Very Low
Vomiting 6 5.00 Very Low Very Low Very Low
Recurrence 6 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both the basal and stimulated alpha-neoendorphin release from striatal slices was significantly increased at all the time points studied.
Positive_regulation (increased) of Localization (release) of alpha-neoendorphin
1) Confidence 0.70 Published 1996 Journal Neuroscience Section Abstract Doc Link 9045086 Disease Relevance 0 Pain Relevance 1.26
On the other hand, the basal and stimulated (K+, 57 mM) release of alpha-neoendorphin from nucleus accumbens slices were significantly elevated only at 24 h after the last morphine injection.
Positive_regulation (elevated) of Localization (release) of alpha-neoendorphin in nucleus accumbens associated with nucleus accumbens and morphine
2) Confidence 0.70 Published 1996 Journal Neuroscience Section Abstract Doc Link 9045086 Disease Relevance 0 Pain Relevance 1.40
In contrast, single and chronic (at 24 and 48 h) amphetamine administration profoundly elevated the release of alpha-neoendorphin in both these structures.
Positive_regulation (elevated) of Localization (release) of alpha-neoendorphin
3) Confidence 0.67 Published 1998 Journal Neuroscience Section Abstract Doc Link 9681945 Disease Relevance 0 Pain Relevance 0.56
Perfusion of the substantia nigra with the nonselective antagonist naltrexone (NTX; 1-10 microM), the selective kappa-opoid receptor antagonist, nor-binaltorphimine (nor-BNI; 1-10 microM), and the selective mu-opioid receptor antagonist, D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH(2) (CTOP; 1-10 microM) produced an increase in dopamine release, both in substantia nigra and neostriatum. nor-BNI also produced an increase in dynorphin B release, and a similar effect was observed with the higher concentration of NTX (10 microM).
Positive_regulation (increase) of Localization (release) of dynorphin B in substantia nigra associated with dopamine, dynorphin, antagonist, substantia nigra and opioid receptor
4) Confidence 0.59 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10454508 Disease Relevance 0 Pain Relevance 1.15
The present results indicate that systemic morphine administration stimulates the release of dynorphin B in the substantia nigra, probably by activating the mu-subtype of opioid receptor, since the effect of morphine on nigral dynorphin B and GABA was antagonized by a low dose of naloxone.
Spec (probably) Positive_regulation (stimulates) of Localization (release) of dynorphin B in substantia nigra associated with gaba, dynorphin, substantia nigra, narcan, opioid receptor and morphine
5) Confidence 0.58 Published 1996 Journal Brain Res. Section Abstract Doc Link 8963665 Disease Relevance 0 Pain Relevance 2.10
The spontaneous immunoreactive alpha-neoendorphin release from spinal cord slices was elevated at all the time points studied, whereas the stimulated release of the peptide was strongly increased 12 h after Freund Adjuvant inoculation but gradually declined on the following days.
Positive_regulation (elevated) of Localization (release) of alpha-neoendorphin in spinal cord associated with spinal cord
6) Confidence 0.55 Published 1992 Journal Neuroscience Section Abstract Doc Link 1594104 Disease Relevance 0 Pain Relevance 0.42
Both the basal and stimulated alpha-neoendorphin release from striatal slices was significantly increased at all the time points studied.
Positive_regulation (increased) of Localization (release) of alpha-neoendorphin
7) Confidence 0.50 Published 1996 Journal Neuroscience Section Abstract Doc Link 9045086 Disease Relevance 0 Pain Relevance 1.26
On the other hand, the basal and stimulated (K+, 57 mM) release of alpha-neoendorphin from nucleus accumbens slices were significantly elevated only at 24 h after the last morphine injection.
Positive_regulation (elevated) of Localization (release) of alpha-neoendorphin in nucleus accumbens associated with nucleus accumbens and morphine
8) Confidence 0.50 Published 1996 Journal Neuroscience Section Abstract Doc Link 9045086 Disease Relevance 0 Pain Relevance 1.40
No significant changes in the basal or K(+)-stimulated alpha-neoendorphin release from hippocampal slices of pentetrazole-treated rats were found at any time points measured.
Positive_regulation (-stimulated) of Localization (release) of alpha-neoendorphin
9) Confidence 0.50 Published 1992 Journal Neuroscience Section Abstract Doc Link 1465197 Disease Relevance 0.14 Pain Relevance 0.07
Potassium-induced depolarization activated PDYN processing and secretion of opioid peptides in neuronal cultures and in a model cell line.
Positive_regulation (activated) of Localization (secretion) of PDYN in neuronal associated with opioid
10) Confidence 0.42 Published 2006 Journal FASEB J. Section Abstract Doc Link 16966485 Disease Relevance 0 Pain Relevance 0.50
Perfusion of the neostriatum with NTX, nor-BNI, or CTOP increased striatal dopamine, and dynorphin B release and increased dynorphin B in the ipsilateral substantia nigra.
Positive_regulation (increased) of Localization (release) of dynorphin B in substantia nigra associated with dopamine, dynorphin and substantia nigra
11) Confidence 0.42 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10454508 Disease Relevance 0 Pain Relevance 1.38
Perfusion of the neostriatum with NTX, nor-BNI, or CTOP increased striatal dopamine, and dynorphin B release and increased dynorphin B in the ipsilateral substantia nigra.
Positive_regulation (increased) of Localization (release) of dynorphin B in substantia nigra associated with dopamine, dynorphin and substantia nigra
12) Confidence 0.39 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10454508 Disease Relevance 0 Pain Relevance 1.42
At a peak time of antinociception (10 min), CP55,940 and Delta(9)-THC induced significant two-fold increases in the release of dynorphin B.
Positive_regulation (increases) of Localization (release) of dynorphin B associated with antinociception and dynorphin
13) Confidence 0.21 Published 2000 Journal Brain Res. Section Abstract Doc Link 10700588 Disease Relevance 0 Pain Relevance 1.48
Previous work in our laboratory has shown that the synthetic, bicyclic cannabinoid, CP55,940, induces the release of dynorphin B whilst the naturally occurring cannabinoid, Delta(9)-tetrahydrocannabinol (Delta(9)-THC), releases dynorphin A.
Positive_regulation (induces) of Localization (release) of dynorphin B associated with dynorphin and cannabinoid
14) Confidence 0.15 Published 2000 Journal Brain Res. Section Abstract Doc Link 10700588 Disease Relevance 0 Pain Relevance 0.97
The present study compares dynorphin B released from perfused rat spinal cord in response to acute administration of anandamide (AEA), Delta(9)-THC and CP55,940 at two time points, 10 min and 30 min post administration, and attempts to correlate such release with antinociceptive effects of the drugs.
Positive_regulation (response) of Localization (released) of dynorphin B in spinal cord associated with dynorphin, antinociceptive and spinal cord
15) Confidence 0.13 Published 2000 Journal Brain Res. Section Abstract Doc Link 10700588 Disease Relevance 0 Pain Relevance 1.14
High-frequency electroacupuncture increases dynorphin release to interact with ?
Positive_regulation (increases) of Localization (release) of dynorphin associated with dynorphin and electroacupuncture
16) Confidence 0.05 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529396 Disease Relevance 0.26 Pain Relevance 1.42
-endorphin and enkephalin in the CNS, whereas high-frequency electroacupuncture produced an increase in dynorphin release (87,88), it has been expected that low-frequency electroacupuncture can play a predominant role in attenuating withdrawal syndrome by activating the ?
Positive_regulation (increase) of Localization (release) of dynorphin associated with dynorphin, enkephalin, withdrawal and electroacupuncture
17) Confidence 0.04 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529396 Disease Relevance 0.37 Pain Relevance 1.56

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