INT101188

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Context Info
Confidence 0.56
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 81
Total Number 82
Disease Relevance 23.43
Pain Relevance 19.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rela) nucleus (Rela) DNA binding (Rela)
protein complex (Rela) transcription factor binding (Rela) cytoplasm (Rela)
Anatomy Link Frequency
astrocytes 13
bone marrow 4
nucleus 3
microglial cell 2
neurons 2
Rela (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 402 99.84 Very High Very High Very High
Morphine 1560 99.82 Very High Very High Very High
cytokine 1578 99.30 Very High Very High Very High
chemokine 293 97.92 Very High Very High Very High
Osteoarthritis 85 97.60 Very High Very High Very High
dorsal root ganglion 6 97.52 Very High Very High Very High
cINOD 19 95.60 Very High Very High Very High
Substantia nigra 185 95.00 High High
Inflammation 728 92.40 High High
Spinal cord 12 91.28 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 181 100.00 Very High Very High Very High
Cancer 401 99.92 Very High Very High Very High
Rheumatoid Arthritis 402 99.84 Very High Very High Very High
Necrosis 70 99.68 Very High Very High Very High
Uveitis 43 99.68 Very High Very High Very High
Myocardial Infarction 29 99.40 Very High Very High Very High
Synovial Sarcoma 140 98.84 Very High Very High Very High
Toxicity 230 97.96 Very High Very High Very High
Osteoarthritis 85 97.60 Very High Very High Very High
Sarcoma 28 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We showed that Tlr4-deficient mice display significantly reduced expression of proinflammatory genes, including RelA, tumor necrosis factor (Thf), interleukin 6 (Il6), chemokine (C-C motif) ligand 2 (Ccl2), chemokine (C-C motif) ligand 5 (Ccl5), chemokine (C-X-C motif) ligand 10 (Cxcl10), Cybb, nitric oxide synthase 2 (Nos2), and intercellular adhesion molecule 1 (Icam1) 24 h after reperfusion.
Gene_expression (expression) of RelA associated with chemokine, necrosis, cancer and adhesions
1) Confidence 0.56 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2956702 Disease Relevance 1.19 Pain Relevance 0.29
In Tlr4 KO mice, however, the expression of RelA, Tnf, Il6, Ccl2, Ccl5, Cxcl10, Gfap, Icam1, Cybb, and Nos2 was significantly reduced relative to WT.
Gene_expression (expression) of RelA
2) Confidence 0.56 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.48 Pain Relevance 0.17
Treatment with Tat alone or in combination with morphine caused time-dependent increases in the percentage of cells expressing p65 (RelA) within their nuclei as compared to vehicle (control) or morphine-treated cells (Fig. 3 A).
Gene_expression (expressing) of RelA associated with morphine
3) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.09 Pain Relevance 0.77
As expected, in astrocytes pretreated with 20 nM LMB, we observed that with longer treatment times an increasing percentage of cells retained nuclear p65 (RelA), until only trace amounts of p65 were detected in the cytoplasm (Fig. 3 A–B).
Gene_expression (detected) of p65 in astrocytes
4) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.08 Pain Relevance 0.87
Treatment with Tat alone or in combination with morphine caused time-dependent increases in the percentage of cells expressing p65 (RelA) within their nuclei as compared to vehicle (control) or morphine-treated cells (Fig. 3 A).
Gene_expression (expressing) of p65 associated with morphine
5) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.09 Pain Relevance 0.76
B p65 expression was evident mainly in cells with the morphology of activated microglia, surrounding the human ?
Gene_expression (expression) of p65 in microglia
6) Confidence 0.47 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0 Pain Relevance 0.22
A ratio was determined by counting every GFAP+ cell containing the p65 in the nucleus divided by the total number of cells (Fig. 3B).
Gene_expression (containing) of p65 in nucleus
7) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.09 Pain Relevance 0.77
As expected, in astrocytes pretreated with 20 nM LMB, we observed that with longer treatment times an increasing percentage of cells retained nuclear p65 (RelA), until only trace amounts of p65 were detected in the cytoplasm (Fig. 3 A–B).
Gene_expression (retained) of RelA in astrocytes
8) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.08 Pain Relevance 0.85
Chelating [Ca2+]i prevented Tat±morphine-induced p65/NF-?
Gene_expression (/) of p65 associated with morphine
9) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.20 Pain Relevance 0.94
Detection of p65 (RelA) in the nuclei of about 5% of astrocytes at 30 min and the ability of BAPTA/AM to markedly reduce p65 (RelA) nuclear labeling in vehicle-treated control cultures suggested that p65 (RelA)/NF-?
Gene_expression (/) of RelA in astrocytes
10) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.51
Detection of p65 (RelA) in the nuclei of about 5% of astrocytes at 30 min and the ability of BAPTA/AM to markedly reduce p65 (RelA) nuclear labeling in vehicle-treated control cultures suggested that p65 (RelA)/NF-?
Gene_expression (/) of p65 in astrocytes
11) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.51
Detection of p65 (RelA) in the nuclei of about 5% of astrocytes at 30 min and the ability of BAPTA/AM to markedly reduce p65 (RelA) nuclear labeling in vehicle-treated control cultures suggested that p65 (RelA)/NF-?
Gene_expression (Detection) of p65 in astrocytes
12) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.62
As expected, in astrocytes pretreated with 20 nM LMB, we observed that with longer treatment times an increasing percentage of cells retained nuclear p65 (RelA), until only trace amounts of p65 were detected in the cytoplasm (Fig. 3 A–B).
Gene_expression (retained) of p65 in astrocytes
13) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.08 Pain Relevance 0.84
Detection of p65 (RelA) in the nuclei of about 5% of astrocytes at 30 min and the ability of BAPTA/AM to markedly reduce p65 (RelA) nuclear labeling in vehicle-treated control cultures suggested that p65 (RelA)/NF-?
Gene_expression (suggested) of RelA in astrocytes
14) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.54
B (p50/p65), p50 homodimer, and c-Rel DNA binding activity compared to cells that lacked the inhibitor.
Gene_expression (/) of p65
15) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.43
Moreover, cytokine release was inhibited despite the retention of the p65 (RelA) subunit in the nucleus.
Gene_expression (retention) of p65 in nucleus associated with cytokine
16) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.06 Pain Relevance 0.89
Detection of p65 (RelA) in the nuclei of about 5% of astrocytes at 30 min and the ability of BAPTA/AM to markedly reduce p65 (RelA) nuclear labeling in vehicle-treated control cultures suggested that p65 (RelA)/NF-?
Gene_expression (Detection) of RelA in astrocytes
17) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.62
Detection of p65 (RelA) in the nuclei of about 5% of astrocytes at 30 min and the ability of BAPTA/AM to markedly reduce p65 (RelA) nuclear labeling in vehicle-treated control cultures suggested that p65 (RelA)/NF-?
Gene_expression (suggested) of p65 in astrocytes
18) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.54
Detection of p65 (RelA) in the nuclei of about 5% of astrocytes at 30 min and the ability of BAPTA/AM to markedly reduce p65 (RelA) nuclear labeling in vehicle-treated control cultures suggested that p65 (RelA)/NF-?
Gene_expression (labeling) of p65 in astrocytes
19) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.56
Detection of p65 (RelA) in the nuclei of about 5% of astrocytes at 30 min and the ability of BAPTA/AM to markedly reduce p65 (RelA) nuclear labeling in vehicle-treated control cultures suggested that p65 (RelA)/NF-?
Gene_expression (labeling) of RelA in astrocytes
20) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.56

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