INT101198

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Context Info
Confidence 0.15
First Reported 2001
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.04
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 4
adrenal gland 2
Grina (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 75 100.00 Very High Very High Very High
Morphine 3 99.98 Very High Very High Very High
Spinal cord 70 99.68 Very High Very High Very High
central sensitization 44 98.90 Very High Very High Very High
Hippocampus 1 98.52 Very High Very High Very High
Inflammation 42 96.04 Very High Very High Very High
carrageenan induced 2 95.16 Very High Very High Very High
Glutamate receptor 1 89.72 High High
Pain 17 85.12 High High
allodynia 28 47.32 Quite Low
Disease Link Frequency Relevance Heat
Nociception 54 98.80 Very High Very High Very High
Frailty 8 96.88 Very High Very High Very High
INFLAMMATION 42 96.04 Very High Very High Very High
Pain 29 85.12 High High
Injury 28 82.32 Quite High
Neuropathic Pain 28 47.32 Quite Low
Hyperalgesia 26 46.76 Quite Low
Disease 6 5.00 Very Low Very Low Very Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Formalin-induced changes of NMDA receptor subunit expression in the spinal cord of the rat.
Regulation (changes) of Gene_expression (expression) of NMDA receptor subunit in spinal cord associated with nmda receptor and spinal cord
1) Confidence 0.15 Published 2002 Journal Amino Acids Section Title Doc Link 12373534 Disease Relevance 0.09 Pain Relevance 0.43
However, it is unclear if extended periods of central sensitization are maintained by NMDA receptor phosphorylation or if changes in NMDA receptor subunit protein expression contribute to the continuance of the sensitized state as was observed in the spinal cord injury model [16].
Regulation (changes) of Gene_expression (expression) of NMDA receptor subunit in spinal cord associated with central sensitization, nmda receptor and spinal cord
2) Confidence 0.06 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.55 Pain Relevance 0.82
The goal was to determine if there is a transition from NMDA receptor subunit phosphorylation to changes in NMDA receptor subunit protein expression during an extended period of nociceptive input and the relationship of these changes to central sensitization.


Regulation (changes) of Gene_expression (expression) of NMDA receptor subunit associated with nociception, central sensitization and nmda receptor
3) Confidence 0.06 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.40 Pain Relevance 0.64
Single dose of morphine influences plasma corticosterone and gene expression of main NMDA receptor subunit in the adrenal gland but not in the hippocampus.
Regulation (influences) of Gene_expression (expression) of NMDA receptor subunit in adrenal gland associated with nmda receptor, hippocampus and morphine
4) Confidence 0.05 Published 2001 Journal Endocr Regul Section Title Doc Link 11858765 Disease Relevance 0 Pain Relevance 0.43

General Comments

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