INT10120

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Context Info
Confidence 0.58
First Reported 1981
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 6.05
Pain Relevance 10.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdyn) plasma membrane (Pdyn)
Anatomy Link Frequency
spinal 2
Myocyte 2
dentate gyrus 2
caudate putamen 2
cardiogenic 2
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 58 100.00 Very High Very High Very High
Dextromethorphan 7 99.98 Very High Very High Very High
cocaine 11 99.88 Very High Very High Very High
Hyperalgesia 20 99.80 Very High Very High Very High
Kinase C 10 99.76 Very High Very High Very High
narcan 6 99.76 Very High Very High Very High
opioid receptor 8 99.68 Very High Very High Very High
Inflammation 24 99.60 Very High Very High Very High
antagonist 6 99.04 Very High Very High Very High
electroacupuncture 18 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 7 100.00 Very High Very High Very High
Hyperalgesia 22 99.80 Very High Very High Very High
INFLAMMATION 18 99.60 Very High Very High Very High
Sprains And Strains 5 98.72 Very High Very High Very High
Cancer 10 95.40 Very High Very High Very High
Hypersensitivity 3 94.72 High High
Pain 28 94.32 High High
Neuropathic Pain 16 93.04 High High
Dyskinesias 6 88.44 High High
Bone Cancer 4 84.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EA significantly (P<0.05) attenuated this hyperalgesia, as shown by increased PWL and PWPT, and inhibited up-regulation of preprodynorphin mRNA and dynorphin compared to sham control.
Negative_regulation (inhibited) of Positive_regulation (up-regulation) of dynorphin associated with hyperalgesia, dynorphin and electroacupuncture
1) Confidence 0.58 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18221900 Disease Relevance 1.29 Pain Relevance 1.63
Moreover, the running-induced upregulation of dynorphin mRNA was blocked by the opioid receptor antagonist naloxone.
Negative_regulation (blocked) of Positive_regulation (upregulation) of dynorphin mRNA associated with dynorphin, antagonist, narcan and opioid receptor
2) Confidence 0.54 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10971637 Disease Relevance 0.42 Pain Relevance 0.77
Cocaine also produced a significant increase in PDYN mRNA in the caudate putamen, whereas GBR12909 has no effect and the selective serotonin uptake inhibitor fluoxetine decreases PDYN mRNA in the same brain region.
Negative_regulation (produced) of Positive_regulation (increase) of PDYN mRNA in caudate putamen associated with serotonin, fluoxetine and cocaine
3) Confidence 0.43 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15306127 Disease Relevance 0 Pain Relevance 0.60
Three and 24 h after pentetrazole administration the level of prodynorphin mRNA in the dentate gyrus was slightly decreased (by c. 30%), but was back to the control values after 72 h.
Negative_regulation (decreased) of Positive_regulation (level) of prodynorphin mRNA in dentate gyrus
4) Confidence 0.43 Published 1992 Journal Neuroscience Section Abstract Doc Link 1465197 Disease Relevance 0.15 Pain Relevance 0.07
EA significantly (P<0.05) attenuated this hyperalgesia, as shown by increased PWL and PWPT, and inhibited up-regulation of preprodynorphin mRNA and dynorphin compared to sham control.
Negative_regulation (inhibited) of Positive_regulation (up-regulation) of preprodynorphin mRNA associated with hyperalgesia, dynorphin and electroacupuncture
5) Confidence 0.43 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18221900 Disease Relevance 1.29 Pain Relevance 1.62
In the particular case of chronic hindpaw inflammation, ERK blockade also prevented the upregulation in the spinal levels of prodynorphin and NK1 receptor observed in such animals [49].
Negative_regulation (prevented) of Positive_regulation (upregulation) of prodynorphin in spinal associated with inflammation
6) Confidence 0.42 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 1.31 Pain Relevance 0.96
Pretreatment of rats with DM decreased hippocampal PENK and PDYN mRNA levels and seizure activity induced by KA.
Negative_regulation (decreased) of Positive_regulation (induced) of PDYN mRNA associated with convulsion and dextromethorphan
7) Confidence 0.41 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179861 Disease Relevance 0.43 Pain Relevance 0.79
Both AIM development and the associated upregulation of prodynorphin mRNA by L-DOPA are significantly inhibited by the intrastriatal infusion of fosB antisense.
Negative_regulation (inhibited) of Positive_regulation (upregulation) of prodynorphin
8) Confidence 0.41 Published 2002 Journal Amino Acids Section Abstract Doc Link 12373525 Disease Relevance 0.56 Pain Relevance 0.03
Caloric restriction of the same diet decreases mRNA levels of proDynorphin, proEnkephalin and POMC, as well as levels of Dynorphin A1-17.
Negative_regulation (decreases) of Positive_regulation (levels) of Dynorphin associated with dynorphin
9) Confidence 0.39 Published 1996 Journal Brain Res. Section Abstract Doc Link 8793092 Disease Relevance 0.07 Pain Relevance 0.42
Moreover, in pulse-chase experiments, radioactivity that appeared in dynorphin B-Arg14 did not decrease, nor did the radioactivity in dynorphin B increase, after chasing with a high concentration of non-radioactive dynorphin B-29.
Neg (not) Negative_regulation (decrease) of Positive_regulation (increase) of dynorphin B associated with dynorphin
10) Confidence 0.30 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2862869 Disease Relevance 0 Pain Relevance 0.71
Endogenous and exogenous glucocorticoid suppresses up-regulation of preprodynorphin mRNA and hyperalgesia in rats with peripheral inflammation.
Negative_regulation (suppresses) of Positive_regulation (up-regulation) of preprodynorphin mRNA associated with hyperalgesia and inflammation
11) Confidence 0.29 Published 2004 Journal Neurosci. Lett. Section Title Doc Link 15050718 Disease Relevance 0.53 Pain Relevance 0.80
Myocyte culture in high KCl resulted, after 4 h, in a marked increase in cellular prodynorphin mRNA, while a KCl treatment for 6, 12, or 24 h progressively down-regulated the levels of prodynorphin mRNA below the control value.
Negative_regulation (down-regulated) of Positive_regulation (levels) of prodynorphin mRNA in Myocyte
12) Confidence 0.27 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 7906274 Disease Relevance 0 Pain Relevance 0.25
Furthermore, dynorphin's action is specific since NAL completely blocked dynorphin induced PRL release.
Negative_regulation (blocked) of Positive_regulation (induced) of dynorphin associated with dynorphin and narcan
13) Confidence 0.14 Published 1981 Journal Endocrinology Section Abstract Doc Link 6111448 Disease Relevance 0 Pain Relevance 0.68
Nuclear treatment with PKC inhibitors abolished the capability of dynorphin B to prime the transcription of cardiogenic genes.
Negative_regulation (abolished) of Positive_regulation (capability) of dynorphin in cardiogenic associated with kinase c and dynorphin
14) Confidence 0.05 Published 2003 Journal Circ. Res. Section Abstract Doc Link 12623878 Disease Relevance 0 Pain Relevance 0.86

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