INT101203

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 12
Total Number 14
Disease Relevance 7.06
Pain Relevance 10.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) extracellular region (Calca) nucleus (Calca)
intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
sciatic nerve 8
spinal cord 6
neurons 2
nerve 2
skin 2
Calca (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 77 100.00 Very High Very High Very High
Calcitonin gene-related peptide 67 100.00 Very High Very High Very High
Neuropeptide 39 100.00 Very High Very High Very High
Somatostatin 17 100.00 Very High Very High Very High
mu opioid receptor 1 100.00 Very High Very High Very High
Sciatic nerve 22 99.98 Very High Very High Very High
substance P 46 99.68 Very High Very High Very High
qutenza 10 99.48 Very High Very High Very High
Spinal cord 18 99.24 Very High Very High Very High
c fibre 1 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 65 100.00 Very High Very High Very High
Ocular Hypertension 1 99.96 Very High Very High Very High
Cancer 11 99.72 Very High Very High Very High
Asthma 1 97.76 Very High Very High Very High
Acanthosis 3 97.48 Very High Very High Very High
Hyperalgesia 10 96.24 Very High Very High Very High
Neuropathic Pain 61 94.40 High High
Inflammatory Pain 20 93.12 High High
Hypersensitivity 4 87.72 High High
Cataract 68 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After irradiation of tumors, significant decreases in the expression of CGRP were shown in the spinal cord, whereas neither substance P nor c-fos showed any alteration.
Negative_regulation (decreases) of Gene_expression (expression) of CGRP in spinal cord associated with cancer, substance p, spinal cord and calcitonin gene-related peptide
1) Confidence 0.59 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15659796 Disease Relevance 1.45 Pain Relevance 1.42
Low affinity NGF receptor (p75 neurotrophin receptor) inhibitory antibody reduces pain behavior and CGRP expression in DRG in the mouse sciatic nerve crush model.
Negative_regulation (reduces) of Gene_expression (expression) of CGRP in sciatic nerve associated with pain and sciatic nerve
2) Confidence 0.56 Published 2010 Journal J. Orthop. Res. Section Title Doc Link 19824062 Disease Relevance 0.57 Pain Relevance 1.00
Intradermal injections of capsaicin prior to UVB-irradiation inhibited the UVB-induced CGRP expression, BrdU labeling in basal keratinocytes and epidermal thickening.
Negative_regulation (inhibited) of Gene_expression (expression) of CGRP in keratinocytes associated with qutenza and calcitonin gene-related peptide
3) Confidence 0.43 Published 2002 Journal J. Dermatol. Sci. Section Abstract Doc Link 11858952 Disease Relevance 0.26 Pain Relevance 0.55
CGRP and p75 NTR immunoreactivity in the L5 DRG neurons was upregulated in the injured nerve groups compared with the sham-operated group; however, p75 NTR inhibitory antibody decreased the CGRP and p75 NTR expression (p < 0.01).
Negative_regulation (decreased) of Gene_expression (expression) of CGRP in nerve associated with calcitonin gene-related peptide
4) Confidence 0.41 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19824062 Disease Relevance 0.53 Pain Relevance 1.01
Application of the p75 NTR inhibitory antibody to the pinched sciatic nerve suppressed CGRP and p75 NTR expression and pain behavior.
Negative_regulation (suppressed) of Gene_expression (expression) of CGRP in sciatic nerve associated with pain, sciatic nerve and calcitonin gene-related peptide
5) Confidence 0.41 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19824062 Disease Relevance 0.60 Pain Relevance 0.98
To explore further the mechanisms involved, we examined suppression of pain behavior and expression of neuropeptides such as calcitonin gene-related peptide (CGRP) using a p75 NTR inhibitory antibody, in a mouse sciatic nerve crush model.
Spec (examined) Negative_regulation (suppression) of Gene_expression (expression) of CGRP in sciatic nerve associated with pain, neuropeptide, sciatic nerve and calcitonin gene-related peptide
6) Confidence 0.41 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19824062 Disease Relevance 0.55 Pain Relevance 0.84
In immunohistochemical staining of the spinal cord, a significant decrease after irradiation was shown in the expression of CGRP, but not in substance P.
Negative_regulation (decrease) of Gene_expression (expression) of CGRP in spinal cord
7) Confidence 0.37 Published 2005 Journal Int. J. Radiat. Oncol. Biol. Phys. Section Body Doc Link 15817359 Disease Relevance 0 Pain Relevance 0
To explore further the mechanisms involved, we examined suppression of pain behavior and expression of neuropeptides such as calcitonin gene-related peptide (CGRP) using a p75 NTR inhibitory antibody, in a mouse sciatic nerve crush model.
Spec (examined) Negative_regulation (suppression) of Gene_expression (expression) of gene-related peptide in sciatic nerve associated with pain, neuropeptide, sciatic nerve and calcitonin gene-related peptide
8) Confidence 0.35 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19824062 Disease Relevance 0.55 Pain Relevance 0.84
Selective elimination of unmyelinated C-fibers by neonatal capsaicin treatment resulted in marked reduction of the c-kit receptor and CGRP expression in the superficial layer of the spinal cord.
Negative_regulation (reduction) of Gene_expression (expression) of CGRP in spinal cord associated with c fibre, qutenza, unmyelinated, spinal cord and calcitonin gene-related peptide
9) Confidence 0.34 Published 2008 Journal Neuroscience Section Abstract Doc Link 18423881 Disease Relevance 0.30 Pain Relevance 1.20
CGRP, somatostatin and VIP as generally suppressive neuropeptides
Negative_regulation (suppressive) of Gene_expression (neuropeptides) of CGRP associated with neuropeptide, somatostatin and calcitonin gene-related peptide
10) Confidence 0.20 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.27 Pain Relevance 0.85
Indeed, after forced Runx1 expression, we observed a selective up-regulation of RET, IB4-binding, and P2X3 in differentiated bTUB+ neurons, as well as a decrease of RT97 and CGRP expression in the transplants.
Negative_regulation (decrease) of Gene_expression (expression) of CGRP in neurons
11) Confidence 0.19 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.30 Pain Relevance 0.31
Expression of CGRP was also greatly reduced (by 78%) (Fig. 4C and 4E).
Negative_regulation (reduced) of Gene_expression (Expression) of CGRP
12) Confidence 0.18 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.06 Pain Relevance 0.39
For example, Oksala et al. [33] found that intracameral injection of calcitonin gene-related peptide (CGRP) increased, whereas intravitreal injection of CGRP decreased intraocular pressure.
Negative_regulation (decreased) of Gene_expression (injection) of CGRP associated with ocular hypertension and calcitonin gene-related peptide
13) Confidence 0.16 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2647562 Disease Relevance 0.83 Pain Relevance 0.15
Peripheral nerves and blood vessels were structurally altered in BERK and hBERK1 skin, with decreased expression of mu opioid receptor and increased calcitonin gene-related peptide and substance P immunoreactivity.
Negative_regulation (decreased) of Gene_expression (expression) of calcitonin in skin associated with mu opioid receptor, substance p and calcitonin gene-related peptide
14) Confidence 0.15 Published 2010 Journal Blood Section Abstract Doc Link 20304807 Disease Relevance 0.79 Pain Relevance 1.18

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