INT101209

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Context Info
Confidence 0.72
First Reported 2002
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 19
Total Number 31
Disease Relevance 25.77
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Wt1) RNA binding (Wt1) nucleus (Wt1)
intracellular (Wt1) DNA binding (Wt1) cytoplasm (Wt1)
Anatomy Link Frequency
podocytes 2
T cells 2
neck 1
lymphocytes 1
head 1
Wt1 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 16 92.16 High High
pain flank 4 83.92 Quite High
cva 3 78.40 Quite High
positron emission tomography 1 74.40 Quite High
palliative 2 69.68 Quite High
anesthesia 1 67.72 Quite High
imagery 5 66.40 Quite High
colic 3 62.68 Quite High
nud 1 49.04 Quite Low
Inflammation 3 23.04 Low Low
Disease Link Frequency Relevance Heat
Cancer 453 100.00 Very High Very High Very High
Myocardial Infarction 7 100.00 Very High Very High Very High
Leukemia 121 99.96 Very High Very High Very High
Primitive Neuroectodermal Tumors 33 99.92 Very High Very High Very High
Mesothelioma 189 99.84 Very High Very High Very High
Lung Cancer 153 99.84 Very High Very High Very High
Hematologic Neoplasms 24 99.84 Very High Very High Very High
Chronic Myeloid Leukemia 24 97.96 Very High Very High Very High
Renal Disease 48 97.44 Very High Very High Very High
Precursor Cell Lymphoblastic Leukemia-lymphoma 12 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the Wilms' tumor 1 (WT1) gene was first isolated as a tumor suppressor gene associated with the Wilms' tumor, the WT1 gene has been shown to be highly expressed in hematopoietic malignancies including acute and chronic myelogenous leukemia, acute lymphocytic leukemia and myelodysplastic syndrome, and a majority of solid tumors including glioblastoma, lung cancer, breast cancer, colorectal cancer, thyroid cancer, renal cancer, bone/soft tissue sarcoma and head/neck squamous cell carcinoma 3.
Gene_expression (expressed) of WT1 in head associated with lung cancer, precursor cell lymphoblastic leukemia-lymphoma, renal cancer, colon cancer, breast cancer, hematologic neoplasms, skin cancer, sarcoma, thyroid neoplasm, cancer, glioblastoma, chronic myeloid leukemia, myelodysplastic syndromes and solid tumor
1) Confidence 0.72 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 2.25 Pain Relevance 0
Cells induced by MLPC for two weeks showed cytotoxicity against the leukemia cell line expressing both HLA-A*2402 and WT1 antigen as well as WT1 peptide-pulsed B-LCL.
Gene_expression (expressing) of WT1 associated with leukemia
2) Confidence 0.72 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 0.10 Pain Relevance 0
In order to investigate the role of the TEV protease, three separate pulldowns were completed using cell extracts from MPC-5 cells stably expressing WT1(+KTS).
Gene_expression (expressing) of WT1
3) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0
Additional pulldowns were performed, using cell extracts from MPC-5 cells stably expressing WT1(+KTS)-FF-ZZ, but also using control cell extracts from MPC-5 cells expressing the empty vector plasmid.
Gene_expression (expressing) of WT1
4) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.06 Pain Relevance 0
However, isolation of the mRNAs occurred independently of the expression of WT1, suggesting that the identified mRNAs were serendipitously co-purified on the basis of co-association in a common subcellular fraction.
Gene_expression (expression) of WT1
5) Confidence 0.70 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2714980 Disease Relevance 0.37 Pain Relevance 0
In conclusion, we have identified a subset of genes with increased expression in noninfarcted left ventricular tissue following MI, including syndecans 1-4, WT-1, fibronectin, collagen 6A, and FGF receptor 1.
Gene_expression (expression) of WT-1 associated with myocardial infarction
6) Confidence 0.64 Published 2004 Journal Physiol. Genomics Section Abstract Doc Link 14625378 Disease Relevance 0.53 Pain Relevance 0.07
Frequency of WT1 peptide/HLA-A*2402 tetramer+ cells
Gene_expression (peptide) of WT1
7) Confidence 0.62 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 0.23 Pain Relevance 0
In addition, we tried to monitor the kinetics of WT1-specific CTLs as well as low frequency immunocompetent cells such as plasmacytoid DCs (pDCs), myeloid dendritic cell-1s (mDC1s), ??
Gene_expression (kinetics) of WT1 in CTLs
8) Confidence 0.62 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 1.85 Pain Relevance 0
Autologous EB-virus transformed B-lymphoblastoid cell line (B-LCL) cells pulsed with WT1 peptides were labeled with 10 ?
Gene_expression (peptides) of WT1
9) Confidence 0.62 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 0.05 Pain Relevance 0
Frequency of WT1/MHC tetramer+CD8+ T cells
Gene_expression (/) of WT1 in T cells
10) Confidence 0.62 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 0.06 Pain Relevance 0
Administration of WT1 peptide
Gene_expression (peptide) of WT1
11) Confidence 0.62 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 1.19 Pain Relevance 0
For this validation two independent pulldowns were performed using fully differentiated WT1(+KTS) expressing MPC-5 cells.
Gene_expression (expressing) of WT1
12) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0
Thus, further studies are needed to further investigate the proposed post-transcriptional functions of WT1 in podocytes as well as other cell types in which it is expressed.
Gene_expression (expressed) of WT1 in podocytes
13) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0
MLPC cells in wells with WT1/MHC tetramer+CD8+ T cells showed cytotoxicity also against the HLA-A*2402+ leukemia cell line (C2F8) expressing WT1 intrinsically (Fig. 5).


Gene_expression (expressing) of WT1 in T cells associated with leukemia
14) Confidence 0.56 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 0.57 Pain Relevance 0
Cells induced by MLPC for two weeks showed cytotoxicity against the leukemia cell line expressing both HLA-A*2402 and WT1 antigen as well as WT1 peptide-pulsed B-LCL.
Gene_expression (expressing) of WT1 associated with leukemia
15) Confidence 0.56 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 0.10 Pain Relevance 0
An in vitro study as to the cytotoxicity of lymphocytes induced by mixed lymphocyte peptide culture demonstrated that cultured lymphocytes possessed cytotoxicity against WT1 expressing leukemia cells and the cytotoxicity was WT1-specific and MHC class I restricted.
Gene_expression (expressing) of WT1 in lymphocytes associated with leukemia
16) Confidence 0.56 Published 2010 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC2860640 Disease Relevance 0.34 Pain Relevance 0
Modified-type WT1 peptide (HLA-A*2402-restricted, 9-mer peptide; CYTWNQMNL) was synthesized in GMP grade by NeoMPS (San Diego, CA, USA).
Gene_expression (synthesized) of WT1
17) Confidence 0.56 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 1.12 Pain Relevance 0
In order to identify potential candidate mRNAs associating with WT1(+KTS), WT1(+KTS) was purified from cell extracts from a podocyte cell line stably expressing an epitope tagged WT1(+KTS) construct.
Gene_expression (expressing) of WT1 in podocyte
18) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.14 Pain Relevance 0
Cell extracts were prepared from WT1(+KTS)-FF-ZZ expressing MPC-5 cells that were allowed to differentiate at 37°C for 14 days.
Gene_expression (expressing) of WT1
19) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.08 Pain Relevance 0.05
MPC-5 cells were established with stable expression of the WT1(+KTS) cDNA containing the FF-ZZ tag.
Gene_expression (expression) of WT1
20) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.08 Pain Relevance 0.03

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