INT101213

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Context Info
Confidence 0.02
First Reported 2002
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.72
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTUS1) Golgi apparatus (MTUS1) plasma membrane (MTUS1)
cytoskeleton (MTUS1) nucleus (MTUS1) microtubule organizing center (MTUS1)
Anatomy Link Frequency
muscle 2
MTUS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
pain flank 1 59.20 Quite High
cva 1 53.68 Quite High
imagery 6 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 23 100.00 Very High Very High Very High
Primitive Neuroectodermal Tumors 11 99.52 Very High Very High Very High
Muscular Atrophy 100 95.06 Very High Very High Very High
Frailty 28 88.36 High High
Hypertrophy 2 87.88 High High
Sarcoma 2 82.40 Quite High
Flank Pain 1 59.20 Quite High
Hematuria 1 57.76 Quite High
Necrosis 1 54.72 Quite High
Hemorrhage 1 53.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the context of muscle atrophy, lower Akt activity decreases the activation of mammalian target of rapamycin (mTOR), leading to decreased protein synthesis and ribosomal biogenesis, as well as decreased mitochondrial biogenesis and function, as mTOR has been shown to regulate mitochondrial gene expression through the regulation of YY1/PGC-1?
Gene_expression (expression) of mitochondrial gene in muscle associated with muscular atrophy
1) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.33 Pain Relevance 0
Together, these findings suggest that signaling through mTOR may decline transiently during the early response of human muscle to immobilization and may contribute to decreased mitochondrial gene expression, possibly through interactions with PGC-1?
Gene_expression (expression) of mitochondrial gene in muscle
2) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.08 Pain Relevance 0
WT-1, the WT-associated tumor suppressor gene, is overexpressed in WT but not in ES/PNET.
Neg (not) Gene_expression (overexpressed) of WT-associated tumor suppressor gene associated with cancer and primitive neuroectodermal tumors
3) Confidence 0.01 Published 2002 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 11859203 Disease Relevance 2.31 Pain Relevance 0.09

General Comments

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