INT101225

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Context Info
Confidence 0.64
First Reported 2001
Last Reported 2010
Negated 4
Speculated 3
Reported most in Body
Documents 62
Total Number 65
Disease Relevance 28.10
Pain Relevance 23.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2) endoplasmic reticulum (Gria2) plasma membrane (Gria2)
protein complex (Gria2)
Anatomy Link Frequency
neurons 11
spinal 6
dorsal horn 3
spike 1
hippocampus 1
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 894 100.00 Very High Very High Very High
depression 626 100.00 Very High Very High Very High
Glutamate 318 100.00 Very High Very High Very High
Glutamate receptor 280 100.00 Very High Very High Very High
agonist 136 100.00 Very High Very High Very High
nMDA receptor 438 99.98 Very High Very High Very High
spinal dorsal horn 112 99.90 Very High Very High Very High
Inflammation 194 99.86 Very High Very High Very High
Central nervous system 172 99.68 Very High Very High Very High
Hippocampus 409 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 630 100.00 Very High Very High Very High
Thiamine Deficiency 310 99.98 Very High Very High Very High
INFLAMMATION 196 99.86 Very High Very High Very High
Nociception 446 99.72 Very High Very High Very High
Targeted Disruption 877 99.68 Very High Very High Very High
Bone Cancer 41 99.48 Very High Very High Very High
Anxiety Disorder 368 99.40 Very High Very High Very High
Disease 71 99.32 Very High Very High Very High
Hyperalgesia 98 99.08 Very High Very High Very High
Injury 74 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DeltaFosB produced these effects through induction of the GluR2 AMPA glutamate receptor subunit, which decreased the responsiveness of nucleus accumbens neurons to glutamate, and through other synaptic proteins.
Positive_regulation (induction) of GluR2 AMPA glutamate receptor subunit in neurons associated with nucleus accumbens, glutamate and glutamate receptor
1) Confidence 0.64 Published 2010 Journal Nat. Neurosci. Section Abstract Doc Link 20473292 Disease Relevance 0.32 Pain Relevance 0.41
They demonstrated that the amount of GluR2 was markedly increased in the crude cytosolic fraction and decreased in the crude membrane fraction from the ipsilateral L4-5 dorsal horn at 24 hour post-CFA injection.
Positive_regulation (increased) of GluR2 in dorsal horn associated with dorsal horn
2) Confidence 0.62 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.47 Pain Relevance 0.55
Finally, an increased AMPA receptor Ca2+ permeability induced more Ca2+ influx in dorsal horn neurons [46].
Positive_regulation (increased) of AMPA receptor in dorsal horn associated with dorsal horn neuron
3) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.93 Pain Relevance 0.62
Indeed, co-immunoprecipitation experiments indicated that AMPA receptor activation induced the association of Gbeta with the alpha-subunit of the Na+ channel.
Positive_regulation (activation) of AMPA
4) Confidence 0.52 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11860490 Disease Relevance 0 Pain Relevance 0.17
AMPA receptor activation induces association of G-beta protein with the alpha subunit of the sodium channel in neurons.
Positive_regulation (activation) of AMPA in neurons associated with sodium channel
5) Confidence 0.52 Published 2001 Journal Eur. J. Neurosci. Section Title Doc Link 11860490 Disease Relevance 0 Pain Relevance 0.11
AMPA receptor activation modified the gating properties of the Na+ channel, independently of the AMPA current, suggesting a G-protein-mediated process.
Positive_regulation (activation) of AMPA
6) Confidence 0.52 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11860490 Disease Relevance 0 Pain Relevance 0.17
Additionally, the antidepressant fluoxetine has been found to alter AMPA receptor phosphorylation in a manner that is expected to increase AMPA receptor signaling.
Positive_regulation (increase) of AMPA receptor associated with antidepressant and fluoxetine
7) Confidence 0.49 Published 2007 Journal CNS Neurol Disord Drug Targets Section Abstract Doc Link 17430149 Disease Relevance 0.30 Pain Relevance 0.54
Consequently, a potential mechanism for NMDAR-independent learning and plasticity in the hippocampus is the expression and activation of GluR2-lacking (Ca2+-permeable) AMPARs.
Positive_regulation (activation) of GluR2 in hippocampus associated with hippocampus
8) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.06 Pain Relevance 0.34
These results demonstrate that context fear conditioning produces normal activation of CA1 neurons in GluR2-cKO animals.
Positive_regulation (activation) of GluR2-cKO in neurons associated with anxiety disorder
9) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.54 Pain Relevance 0.13
Activation of Ca2+-permeable AMPA receptors in the spinal dorsal horn can enhance the AMPA receptor-mediated synaptic transmission [17].


Positive_regulation (enhance) of AMPA receptor in spinal associated with spinal dorsal horn
10) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.10 Pain Relevance 0.48
Additionally, potential changes in GluR2 mRNA editing in disease states may modulate nociceptive responses by altering AMPA receptor composition in the spinal dorsal horn.
Positive_regulation (changes) of GluR2 in spinal associated with nociception, spinal dorsal horn and disease
11) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.90 Pain Relevance 0.63
The magnitude of synaptic potentiation was significantly enhanced in GluA2-/- mice (134.2 ± 5.6% for WTCD1 versus 160.1 ± 10.1% for GluA2-/-, t-test; P < 0.05).
Positive_regulation (enhanced) of GluA2
12) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.33 Pain Relevance 0.51
Stimulation in the absence of postsynaptic hyperpolarization did not produce potentiation in GluR2-cKO mice (Fig. 4B).
Positive_regulation (potentiation) of GluR2-cKO
13) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.13 Pain Relevance 0.38
A study in GluR2-deficient mice has shown that an increase in spinal Ca2+-permeable AMPA receptors might facilitate nociceptive plasticity and enhance long-lasting inflammatory hyperalgesia [51].
Positive_regulation (increase) of AMPA in spinal associated with nociception, hyperalgesia and inflammation
14) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.61 Pain Relevance 0.40
The interaction may be responsible for the insertion and stabilization of AMPA receptors containing GluR2/3 subunits [64].
Positive_regulation (stabilization) of AMPA
15) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.31 Pain Relevance 0.30
The increased synaptic ratio of GluR1 to GluR2 subunit, in turn, might result in an increase in spinal Ca2+-permeable AMPA receptors in the spinal dorsal horn.
Positive_regulation (increase) of AMPA in dorsal horn associated with spinal dorsal horn
16) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.58 Pain Relevance 0.40
The rapid alterations in the composition of synaptic AMPA receptors induced by physiologic activity or noxious stimuli can be achieved by modulating the phosphorylation status of GluR1 and GluR2 subunits and their binding to PDZ domain-containing synaptic scaffolding proteins.
Positive_regulation (induced) of AMPA
17) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 1.10 Pain Relevance 0.70
AMPA receptors are widely distributed in the CNS.
Positive_regulation (distributed) of AMPA associated with central nervous system
18) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.56 Pain Relevance 0.91
The rapid alterations in the composition of synaptic AMPA receptors induced by various stimuli may occur in the cerebellum, the hippocampus and the cortex.
Positive_regulation (induced) of AMPA in cerebellum associated with hippocampus
19) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.45 Pain Relevance 0.46
Activation of Ca2+-permeable AMPA receptors in the spinal dorsal horn can enhance the AMPA receptor-mediated synaptic transmission [17].


Positive_regulation (Activation) of AMPA in spinal associated with spinal dorsal horn
20) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.10 Pain Relevance 0.49

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