INT101226

Context Info Confidence 0.05 First Reported 2001 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0 Pain Relevance 0.20

cytoskeletal protein binding (Anxa2) extracellular region (Anxa2) proteinaceous extracellular matrix (Anxa2) plasma membrane (Anxa2) protein complex (Anxa2) cytoplasm (Anxa2)

Anxa2 (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 1 81.00 cerebral cortex 1 80.48 tetrodotoxin 4 77.76 sodium channel 17 75.00 Pain 9 47.40 diabetic neuropathy 2 42.44 Eae 2 40.16 Neuronal excitability 1 33.36 Inflammation 56 11.68 Arthritis 2 10.04

Disease Link Frequency Relevance Heat Cancer 31 50.00 Pain 13 47.40 Diabetic Neuropathy 2 42.44 Injury 7 40.16 Targeted Disruption 9 17.12 Wound Healing 1 15.88 INFLAMMATION 59 12.40 Arthritis 1 10.04 Apoptosis 14 5.00 Stress 13 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It will form a heterotetramer with Annexin A2, and it has been called "Annexin A2 light chain" [110].

Annexin A2 Binding (heterotetramer) of

1) Confidence 0.05 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0 Pain Relevance 0

Annexin II, interacts in a Ca2+-dependent manner with negatively charged phospholipids, also binding to cholesterol and many protein ligands including actin, and is thought to be involved in many membrane-related events including endosome membrane trafficking along the recycling and degradation pathways [23,2].

Annexin II Binding (interacts) of

2) Confidence 0.04 Published 2010 Journal Neuroscience Letters Section Body Doc Link PMC2977848 Disease Relevance 0 Pain Relevance 0.08

This distinction cannot be made for the ionotropic receptor subclass activated by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), which has been shown to be physically associated with the alpha-subunit of Gi1 protein and activates this G-protein.

Gi1 protein Binding (associated) of

3) Confidence 0.01 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11860490 Disease Relevance 0 Pain Relevance 0.12

General Comments

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