INT101229

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.20
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2) endoplasmic reticulum (Gria2) plasma membrane (Gria2)
protein complex (Gria2)
Anatomy Link Frequency
dorsal horn 4
neurons 2
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 89 99.40 Very High Very High Very High
spinal dorsal horn 14 99.28 Very High Very High Very High
antagonist 59 99.24 Very High Very High Very High
Dorsal horn neuron 12 99.16 Very High Very High Very High
sodium channel 2 97.56 Very High Very High Very High
central sensitization 18 93.12 High High
Kinase C 36 92.08 High High
Spinal cord 20 90.80 High High
tetrodotoxin 2 90.60 High High
Anterior cingulate cortex 82 90.28 High High
Disease Link Frequency Relevance Heat
Nociception 59 99.80 Very High Very High Very High
Targeted Disruption 8 99.28 Very High Very High Very High
Hyperalgesia 13 86.48 High High
Inflammatory Pain 23 85.68 High High
INFLAMMATION 27 84.08 Quite High
Disease 2 77.44 Quite High
Neuropathic Pain 9 72.00 Quite High
Hypersensitivity 13 70.96 Quite High
Neurodegenerative Disease 4 61.68 Quite High
Motor Neuron Diseases 2 58.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased synaptic ratio of GluR1 to GluR2 subunit, in turn, might result in an increase in spinal Ca2+-permeable AMPA receptors in the spinal dorsal horn.
Spec (might) Positive_regulation (result) of Positive_regulation (increase) of AMPA in dorsal horn associated with spinal dorsal horn
1) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.58 Pain Relevance 0.40
Nociceptive-activity induced cortical ERK1/2 activation in AMPA receptor subunit knockout mice
Positive_regulation (induced) of Positive_regulation (activation) of AMPA associated with targeted disruption and nociception
2) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.68 Pain Relevance 0.37
Finally, an increased AMPA receptor Ca2+ permeability induced more Ca2+ influx in dorsal horn neurons [46].
Positive_regulation (induced) of Positive_regulation (increased) of AMPA receptor in dorsal horn associated with dorsal horn neuron
3) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.94 Pain Relevance 0.62
Indeed, co-immunoprecipitation experiments indicated that AMPA receptor activation induced the association of Gbeta with the alpha-subunit of the Na+ channel.
Positive_regulation (induced) of Positive_regulation (activation) of AMPA
4) Confidence 0.38 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11860490 Disease Relevance 0 Pain Relevance 0.17
AMPA receptor activation induces association of G-beta protein with the alpha subunit of the sodium channel in neurons.
Positive_regulation (induces) of Positive_regulation (activation) of AMPA in neurons associated with sodium channel
5) Confidence 0.38 Published 2001 Journal Eur. J. Neurosci. Section Title Doc Link 11860490 Disease Relevance 0 Pain Relevance 0.11
Our studies confirm the observation of Karasawa et al. 2005 that the antidepressant-like activity of MGS0039 was dependent on AMPA receptor activation, as AMPA receptor antagonist, NBQX, given at a dose of 10 mg/kg, prevented its antidepressant-like activity in the TST.
Positive_regulation (dependent) of Positive_regulation (activation) of AMPA associated with antidepressant and antagonist
6) Confidence 0.04 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0 Pain Relevance 0.48

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox