INT101239

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Context Info
Confidence 0.76
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 5.91
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (NTF3) extracellular region (NTF3) cytoplasmic membrane-bounded vesicle (NTF3)
plasma membrane (NTF3) cell-cell signaling (NTF3)
Anatomy Link Frequency
nerve 4
neurons 3
brain 1
ganglia 1
keratinocytes 1
NTF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 73 100.00 Very High Very High Very High
trk C 1 99.04 Very High Very High Very High
diabetic neuropathy 3 96.44 Very High Very High Very High
abdominal pain 1 92.24 High High
Trk A 3 91.20 High High
Inflammation 18 90.08 High High
Crohn's disease 1 89.16 High High
nociceptor 1 88.76 High High
induced neuropathy 3 86.72 High High
hypoalgesia 1 79.80 Quite High
Disease Link Frequency Relevance Heat
Cold Sores 6 99.82 Very High Very High Very High
Death 32 99.12 Very High Very High Very High
Spinal Cord Injury 212 96.76 Very High Very High Very High
Diabetic Neuropathy 3 96.44 Very High Very High Very High
Neuropathic Pain 24 96.40 Very High Very High Very High
Apoptosis 33 94.24 High High
Diarrhoea 1 94.00 High High
Injury 133 93.88 High High
Herpes Simplex Virus 6 93.84 High High
Hypoxia 1 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following subcutaneous inoculation of HSV vectors expressing nerve growth factor (NGF) or neurotrophin-3 (NT-3), neurons in the DRG were transduced to produce NGF or NT-3 in vivo.
Gene_expression (expressing) of NT-3 in neurons associated with cold sores and nerve growth factor
1) Confidence 0.76 Published 2004 Journal Brain Section Abstract Doc Link 14749293 Disease Relevance 0.78 Pain Relevance 0.31
Following subcutaneous inoculation of HSV vectors expressing nerve growth factor (NGF) or neurotrophin-3 (NT-3), neurons in the DRG were transduced to produce NGF or NT-3 in vivo.
Gene_expression (expressing) of neurotrophin-3 in neurons associated with cold sores and nerve growth factor
2) Confidence 0.76 Published 2004 Journal Brain Section Abstract Doc Link 14749293 Disease Relevance 0.77 Pain Relevance 0.31
Following subcutaneous inoculation of HSV vectors expressing nerve growth factor (NGF) or neurotrophin-3 (NT-3), neurons in the DRG were transduced to produce NGF or NT-3 in vivo.
Gene_expression (produce) of NT-3 in neurons associated with cold sores and nerve growth factor
3) Confidence 0.76 Published 2004 Journal Brain Section Abstract Doc Link 14749293 Disease Relevance 0.77 Pain Relevance 0.32
Neurotrophin-3 (NT-3), which regulates IK1 expression, was also observed in fewer neurons of the myenteric ganglia in Crohn's bowel (p = 0.048), and in inflamed colonic extracts by Western blotting (p = 0.004); the numbers of neurons expressing the NT-3 high affinity receptor trk C were unchanged.
Gene_expression (expressing) of NT-3 in ganglia associated with trk c
4) Confidence 0.76 Published 2003 Journal Neuroreport Section Abstract Doc Link 12598727 Disease Relevance 0.37 Pain Relevance 0.27
NGF and glial cell line-derived neurotrophic factor (GDNF) are both produced by basal keratinocytes and neurotrophin (NT-3) by suprabasal keratinocytes: relative mRNA expression was significantly lower in early diabetic neuropathy skin compared to controls, for NGF (P < 0.02), BDNF (P < 0.05), NT-3 (P < 0.05), GDNF (< 0.02), but not NT4/5, Trk A or p75 neurotrophin receptor (all P > 0.05).
Gene_expression (produced) of NT-3 in keratinocytes associated with nerve growth factor, trk a and diabetic neuropathy
5) Confidence 0.47 Published 2004 Journal Prog. Brain Res. Section Abstract Doc Link 14699981 Disease Relevance 1.42 Pain Relevance 1.06
S1b) indicated that hMNPs both express and secrete neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), nerve growth factor (NGF), and vascular endothelial-derived growth factor (VEGF).
Gene_expression (express) of neurotrophin-3 in nerve associated with nerve growth factor
6) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0 Pain Relevance 0.16
Specifically, hMNPs expressed NT-3, NT-4, and NGF, which, have all been shown to have beneficial effects following SCI [24], [25].
Gene_expression (expressed) of NT-3 associated with nerve growth factor and spinal cord injury
7) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.72 Pain Relevance 0.12
S1b) indicated that hMNPs both express and secrete neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), nerve growth factor (NGF), and vascular endothelial-derived growth factor (VEGF).
Gene_expression (express) of NT-3 in nerve associated with nerve growth factor
8) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0 Pain Relevance 0.16
Proteins were probed with antibodies against NT-3, NT-4, NGF (1?
Gene_expression (probed) of NT-3 associated with nerve growth factor
9) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0 Pain Relevance 0.05
These osteoblasts were shown to produce nerve growth factor and brain-derived neurotrophic factor but not neurotrophin-3, as measured by ELISA. hFOB osteoblasts, cultured at 34 degrees C, secreted significantly (P < 0.01) more brain-derived neurotrophic factor and nerve growth factor into the medium than hFOB cells cultured at 39 degrees C.
Neg (not) Gene_expression (produce) of neurotrophin-3 in nerve associated with nerve growth factor
10) Confidence 0.15 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861369 Disease Relevance 0.84 Pain Relevance 0.10
Those include GDNF (Widmer et al., 2000), BDNF, NT-3, NT-4/5, nerve growth factor (NGF) (Studer et al., 1995; Studer et al., 1996), and TGF-alpha (Alexi and Hefti, 1993).
Gene_expression (/) of NT-3 in nerve associated with nerve growth factor
11) Confidence 0.05 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525922 Disease Relevance 0 Pain Relevance 0.05
These observations prompt the intriguing question of whether it is possible for US to trigger these pathways in the brain or the production and secretion of growth factors such as brain-derived neurotrophic factor, neurotrophin-3, or nerve growth factor.
Gene_expression (production) of neurotrophin-3 in brain associated with nerve growth factor
12) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2568804 Disease Relevance 0.26 Pain Relevance 0.05

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