INT101243

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Context Info
Confidence 0.62
First Reported 2002
Last Reported 2010
Negated 3
Speculated 4
Reported most in Body
Documents 12
Total Number 16
Disease Relevance 9.98
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) DNA binding (STAT3) cytoplasm (STAT3)
signal transducer activity (STAT3) cell proliferation (STAT3) cytosol (STAT3)
Anatomy Link Frequency
neck 1
platelets 1
nucleus 1
head 1
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 46 99.64 Very High Very High Very High
opioid receptor 7 99.50 Very High Very High Very High
cytokine 21 89.68 High High
Inflammation 36 88.48 High High
qutenza 3 87.76 High High
cINOD 11 86.08 High High
Central nervous system 11 85.28 High High
analgesia 1 81.96 Quite High
Inflammatory response 3 77.76 Quite High
Endogenous opioid 1 75.24 Quite High
Disease Link Frequency Relevance Heat
Coronary Heart Disease 22 99.68 Very High Very High Very High
Multiple Myeloma 54 99.64 Very High Very High Very High
Skin Cancer 30 99.20 Very High Very High Very High
Cancer 226 98.62 Very High Very High Very High
Infection 4 98.48 Very High Very High Very High
Chronic Lymphoid Leukemia 7 97.60 Very High Very High Very High
Neuromyelitis Optica 81 96.64 Very High Very High Very High
Thyroid Neoplasm 2 96.24 Very High Very High Very High
Metastasis 127 95.44 Very High Very High Very High
Disease 56 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot experiments showed that short-term treatment of cells with sulindac resulted in a large reduction of phosphorylated Stat3, without significantly affecting Stat3 protein levels.
Neg (without) Regulation (affecting) of Stat3
1) Confidence 0.62 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.83 Pain Relevance 0.15
To study changes in STAT3 during cardiac hypertrophy, we initially utilized a RVPO model and analyzed both cellular distribution and phosphorylation of STAT3.
Regulation (changes) of STAT3 associated with coronary heart disease
2) Confidence 0.57 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.10 Pain Relevance 0
Because constitutive activation of signal transducer and activator of transcription 3 (Stat3) has been linked to carcinogenesis of various tumors including head and neck SCCa, we studied whether sulindac treatment affects the Stat3 signaling pathway in oral SCCa cells.
Spec (whether) Regulation (affects) of Stat3 in neck associated with cancer and skin cancer
3) Confidence 0.45 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.87 Pain Relevance 0.16
Using transcription factor decoy oligonucleotides, direct evidence was provided that the up-regulation of mu-opioid receptor mRNA in intact cells is dependent on the transcription factors signal transducers and activators of transcription 1 (STAT1) and STAT3, whereas other transcription factors, such as activator protein-1, nuclear factor (NF)-kappaB, or NF-interleukin-6 are not involved.
Regulation (dependent) of STAT3 associated with opioid receptor
4) Confidence 0.43 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15448191 Disease Relevance 0.24 Pain Relevance 0.56
Because the transcription factor signal transducer and activator of transcription 3 (STAT3) has been closely linked with tumorigenesis, we investigated the effect of this vanilloid on the STAT3 pathway in human multiple myeloma cells.
Spec (investigated) Regulation (effect) of STAT3 associated with multiple myeloma
5) Confidence 0.42 Published 2007 Journal Clin. Cancer Res. Section Abstract Doc Link 17505005 Disease Relevance 0.10 Pain Relevance 0.16
Three other male-specific hubs are directly associated with STAT 3 regulation in platelets.
Regulation (regulation) of STAT 3 in platelets
6) Confidence 0.42 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958630 Disease Relevance 0 Pain Relevance 0
agonists inhibit the IL-6-regulated Stat3 signaling cascade, a role for PPAR?
Regulation (regulated) of Stat3 associated with agonist
7) Confidence 0.26 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.97 Pain Relevance 0.16
There was no difference in the distribution of allele and genotype in either JAK2 or STAT3 between AS groups and controls.
Neg (no) Regulation (difference) of STAT3
8) Confidence 0.24 Published 2010 Journal Clin. Immunol. Section Abstract Doc Link 20627814 Disease Relevance 0.16 Pain Relevance 0.12
These data confirm that STAT3 is regulated by ?
Regulation (regulated) of STAT3
9) Confidence 0.23 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0 Pain Relevance 0.03
B, STAT3 and their target cyclin D1 levels, as well as induction of Nrf2.
Regulation (target) of STAT3
10) Confidence 0.22 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 1.53 Pain Relevance 0
However, infection with dominant negative c-Src adenovirus was unable to block RGD-stimulated changes on either STAT3 or BMX.
Regulation (changes) of STAT3 associated with infection
11) Confidence 0.22 Published 2008 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC2443357 Disease Relevance 0.38 Pain Relevance 0
However, our studies indicate that the tyrosine phosphorylation of STAT3 in 48 h PO myocardium does not appear to be required for the increased level of STAT3 in the nucleus, since the distribution of STAT3 or P-STAT3 between cytoplasm and nucleus was not significantly altered in 48 h PO myocardium.
Neg (not) Regulation (altered) of STAT3 in nucleus
12) Confidence 0.22 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.17 Pain Relevance 0.08
Because constitutive activation of signal transducer and activator of transcription 3 (Stat3) has been linked to carcinogenesis of various tumors including head and neck SCCa, we studied whether sulindac treatment affects the Stat3 signaling pathway in oral SCCa cells.
Spec (whether) Regulation (affects) of Stat3 in head associated with cancer and skin cancer
13) Confidence 0.15 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.87 Pain Relevance 0.16
Fibrinogen gamma (FGG) is one of the target genes of STAT3, as STAT3 is reported to control the transcription of the FGG gene [31].
Regulation (target) of STAT3
14) Confidence 0.13 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2730746 Disease Relevance 1.34 Pain Relevance 0.19
In this context, the signal transducer and activator of transcription 3 (Stat3) might be an interesting target.
Spec (might) Regulation (target) of Stat3
15) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2942853 Disease Relevance 1.73 Pain Relevance 0
Down-regulation of Akt-related and signal transducer and activator of transcription (STAT-3)-related pathways was found in indomethacin-treated cells.
Regulation (regulation) of STAT-3
16) Confidence 0.04 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19250643 Disease Relevance 0.71 Pain Relevance 0.15

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