INT101246

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Context Info
Confidence 0.68
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.03
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Gata6) DNA binding (Gata6) transcription factor binding (Gata6)
Anatomy Link Frequency
smooth muscle 1
Gata6 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 31 99.76 Very High Very High Very High
Inflammation 6 99.66 Very High Very High Very High
alcohol 1 26.72 Quite Low
imagery 14 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 9 99.66 Very High Very High Very High
Apoptosis 22 98.36 Very High Very High Very High
Colon Cancer 13 93.80 High High
Malignant Neoplastic Disease 6 93.52 High High
Bladder Exstrophy 44 88.68 High High
Pancreatic Cancer 28 77.88 Quite High
Thrombocytopenia 1 77.68 Quite High
Adenocarcinoma 21 74.80 Quite High
Deafness 1 68.68 Quite High
Cancer 65 68.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ectopic GATA-6 expression blocked NSAID induction of 15-LOX-1 and apoptosis.
Gene_expression (expression) of GATA-6 associated with cinod and apoptosis
1) Confidence 0.68 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861401 Disease Relevance 0.65 Pain Relevance 0.87
Beginning within 4 h, NSAIDs progressively down-regulated GATA-6 expression.
Gene_expression (expression) of GATA-6 associated with cinod
2) Confidence 0.68 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861401 Disease Relevance 0.65 Pain Relevance 0.87
We then studied NSAID effects on GATA-6, a transcription factor that suppresses 15-LOX-1 expression.
Gene_expression (expression) of GATA-6 associated with cinod
3) Confidence 0.59 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861401 Disease Relevance 0.67 Pain Relevance 0.89
A further characterization of TS versus ES cells indicated that genes such as Gata3, IRX3, EndoA, Bmp8b, Sin 3b and Gata6 are all more highly expressed in TS cells than in ES cells, indicating that they may play specific roles in TE cell differentiation (Tanaka et al., 2002; Hamatani et al., 2004).
Gene_expression (expressed) of Gata6
4) Confidence 0.38 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639449 Disease Relevance 0 Pain Relevance 0
Analysis of these signatures revealed over-expression of inflammatory genes and under-expression of developmental genes, including smooth muscle genes like GATA6 and connexin 43.
Gene_expression (expression) of GATA6 in smooth muscle associated with inflammation
5) Confidence 0.31 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2777855 Disease Relevance 0.46 Pain Relevance 0.05
In addition to these target genes we identified an amplification of the chromosomal region 18q11.2 containing the gene for the transcription factor GATA-6, whose gain and overexpression may play an important and hitherto uninvestigated role in pancreatic carcinogenesis [30].
Gene_expression (overexpression) of GATA-6
6) Confidence 0.25 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.61 Pain Relevance 0

General Comments

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