INT10129

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Context Info
Confidence 0.65
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.40
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F12) extracellular space (F12) extracellular region (F12)
Anatomy Link Frequency
plasma 1
F12 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 5 93.24 High High
bradykinin 7 88.40 High High
abdominal pain 10 85.68 High High
Pain 3 78.08 Quite High
Antihistamine 22 5.00 Very Low Very Low Very Low
corticosteroid 10 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
b2 receptor 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 9 98.76 Very High Very High Very High
Hereditary Angioedema 266 98.36 Very High Very High Very High
Disease 45 95.40 Very High Very High Very High
Septic Shock 2 95.20 Very High Very High Very High
Angina 1 93.24 High High
Thrombosis 62 88.56 High High
Abdominal Pain 10 85.68 High High
Laryngeal Edema 12 82.00 Quite High
Pain 3 78.08 Quite High
Streptococcus Infection 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Measurement of inhibited FXIIa (as the FXIIa-C1-inhibitor complex) suggested that the level of this inhibitor complex was associated with cardiovascular risk [27].
Gene_expression (complex) of FXII
1) Confidence 0.65 Published 2010 Journal Thromb J Section Body Doc Link PMC2871266 Disease Relevance 0.96 Pain Relevance 0.09
Hence, the following types of HAE can be differentiated today: (a) hereditary angioedema due to a genetic C1-INH deficiency (HAE-C1-INH) including type I and type II; and (b) hereditary angioedema with normal C1-INH (HAE type III) including hereditary angioedema due to the two known mutations in the coagulation factor XII gene (HAE-FXII) and hereditary angioedema with an unknown genetic cause (normal C1-INH activity in plasma, no causative mutation in the gene coding for C1-INH and none of the known FXII gene mutations Thr309Lys or Thr309Arg) (HAE-unknown).


Neg (none) Gene_expression (none) of FXII in plasma associated with hereditary angioedema
2) Confidence 0.06 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2919521 Disease Relevance 1.51 Pain Relevance 0.15
The location of these mutations is the same locus, 5q33-qter of the Hageman factor or coagulation FXII gene (Online Mendelian Inheritance in Man # 610619).
Gene_expression (qter) of FXII
3) Confidence 0.05 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2919521 Disease Relevance 0.60 Pain Relevance 0
Levels of factor XII were reduced in 2 patients who had single factor assays performed, consistent with activation of the kallikrein-kinin system.
Gene_expression (Levels) of factor XII
4) Confidence 0.02 Published 2000 Journal Clin. Infect. Dis. Section Abstract Doc Link 10880316 Disease Relevance 0.33 Pain Relevance 0.12
RESULTS: The AMI group showed a significant reduction in F XII activity, F XII activity-to-concentration ratio, and HMWK concentration.
Gene_expression (concentration) of F XII
5) Confidence 0.01 Published 1992 Journal Am. J. Med. Section Body Doc Link 1466361 Disease Relevance 0 Pain Relevance 0

General Comments

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