INT10130

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Context Info
Confidence 0.53
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.62
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinf1) extracellular region (Serpinf1)
Anatomy Link Frequency
epithelium 4
retina 1
plaque 1
corneas 1
Serpinf1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 17 97.16 Very High Very High Very High
Inflammation 99 94.40 High High
cytokine 14 75.68 Quite High
chemokine 10 52.80 Quite High
headache 1 50.48 Quite High
Angina 5 50.00 Quite Low
anesthesia 11 5.00 Very Low Very Low Very Low
ketamine 10 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Age-related Macular Degeneration 25 99.28 Very High Very High Very High
Necrosis 8 98.56 Very High Very High Very High
Cancer 25 98.20 Very High Very High Very High
Hemorrhage 2 96.52 Very High Very High Very High
Pancytopenia 1 96.12 Very High Very High Very High
Myopia 5 95.72 Very High Very High Very High
Corneal Neovascularization 228 95.28 Very High Very High Very High
Hypoxia 4 94.64 High High
Leukemia 3 94.44 High High
INFLAMMATION 108 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
were significantly repressed in PSP-treated corneas compared to control corneas whereas the anti-angiogenic factor, PEDF, was upregulated in PSP-treated corneas when compared to the control corneas (Figure 5).
Positive_regulation (upregulated) of PEDF in corneas
1) Confidence 0.53 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2751803 Disease Relevance 0.64 Pain Relevance 0.22
Transfection of AAV-PEDF resulted in a significant increase in PEDF protein level in retina from DBA/2J mice at 11 months of age (Figure 7C).
Positive_regulation (increase) of PEDF protein in retina
2) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.13 Pain Relevance 0
Intravitreal bevacizumab injections have been found to reduce aqueous VEGF and increase PEDF in patients with choroidal neovascularization secondary to age-related macular degeneration or pathologic myopia [48].
Positive_regulation (increase) of PEDF associated with myopia and age-related macular degeneration
3) Confidence 0.34 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779062 Disease Relevance 0.91 Pain Relevance 0.08
Studies have shown that there is a balance in the cornea between angiogenic molecules such as VEGF and erythropoietin (EPO) and anti-angiogenic molecules such as pigment epithelium derived factor (PEDF).
Positive_regulation (derived) of PEDF in epithelium
4) Confidence 0.32 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779062 Disease Relevance 0.89 Pain Relevance 0.07
mRNAs, and an increased level of pigment epithelium-derived factor (PEDF) mRNA.
Positive_regulation (increased) of PEDF in epithelium
5) Confidence 0.31 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2751803 Disease Relevance 0.96 Pain Relevance 0.14
mRNAs, and an increased level of pigment epithelium-derived factor (PEDF) mRNA.
Positive_regulation (increased) of epithelium-derived factor in epithelium
6) Confidence 0.31 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2751803 Disease Relevance 0.96 Pain Relevance 0.14
Several angiogenesis inhibitors have also been identified in the cornea, such as thrombospondin-1 (TSP-1), pigment epithelium-derived factor (PEDF), prolactin, angiostatin, and endostatin [1].
Positive_regulation (pigment) of epithelium-derived factor in epithelium
7) Confidence 0.16 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2913137 Disease Relevance 0.32 Pain Relevance 0
These effects may promote plaque stabilization, and therapeutic intervention that enhances SDF-1alpha activity could potentially be beneficial in acute coronary syndromes.


Positive_regulation (enhances) of SDF in plaque
8) Confidence 0.01 Published 2002 Journal Circulation Section Body Doc Link 12093767 Disease Relevance 0 Pain Relevance 0
Furthermore, the latter group exhibited an elevation of F VIII activity, alpha 2-macroglobulin activity, and alpha 1-antitrypsin concentration and a significant reduction of antiplasmin activity despite a normal alpha 2-antiplasmin concentration.
Positive_regulation (reduction) of antiplasmin
9) Confidence 0.00 Published 1992 Journal Am. J. Med. Section Body Doc Link 1466361 Disease Relevance 0 Pain Relevance 0
Moreover, an excessive elevation of plasmin-antiplasmin complexes (9,200 ng/ml; normal range: 10-150), an elevated D-dimer, and an increase in thrombin-antithrombin III complexes were found.
Positive_regulation (elevation) of plasmin-antiplasmin
10) Confidence 0.00 Published 1999 Journal Am. J. Hematol. Section Abstract Doc Link 10331514 Disease Relevance 0.82 Pain Relevance 0.05

General Comments

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