INT101301

Context Info Confidence 0.42 First Reported 2002 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 17 Total Number 17 Disease Relevance 16.43 Pain Relevance 4.06

cytosol (Aif1) plasma membrane (Aif1) cytoskeleton (Aif1) cytoplasm (Aif1)

Anatomy Link Frequency spinal cord 2 dorsal 1 Macrophage 1 microglia 1 frontal cortex 1 Aif1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 265 100.00 Spinal cord 141 99.60 Neuropathic pain 256 96.18 cytokine 166 94.48 tolerance 16 93.00 Sciatic nerve 11 91.64 Crohn's disease 50 90.24 Dorsal horn 41 88.92 chemokine 76 87.72 Neuritis 1 86.40

Disease Link Frequency Relevance Heat Chlamydia Infection 335 100.00 INFLAMMATION 253 100.00 Pneumonia 33 99.70 Nicotine Addiction 351 99.64 Urological Neuroanatomy 5 99.64 Hypersensitivity 185 99.24 Infection 133 99.16 Diabetes Mellitus 616 99.04 Inflammatory Bowel Disease 38 99.04 Emphysema 9 98.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Staining of the frontal cortex showed increased IBA1 expression in the mutant versus wild type mice (Figure 7C,D).

Gene_expression (expression) of IBA1 in frontal cortex associated with urological neuroanatomy

1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.56 Pain Relevance 0

We used quantitative image analysis of immunoreactivity for Iba1, the expression of which is upregulated following activation of microglia, as a measure of cell activity.

Gene_expression (expression) of Iba1 in microglia

2) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0 Pain Relevance 0.29

Macrophage-restricted and interferon gamma-inducible expression of the allograft inflammatory factor-1 gene requires Pu.1.

Gene_expression (expression) of allograft inflammatory factor-1 gene in Macrophage associated with inflammation

3) Confidence 0.22 Published 2002 Journal J. Biol. Chem. Section Title Doc Link 11861656 Disease Relevance 0.38 Pain Relevance 0.23

Iba-1 protein expression increased over time in diabetic spinal cord specimens (Figure 3) as compared to non-diabetic specimens.

Gene_expression (expression) of Iba-1 in spinal cord associated with diabetes mellitus and spinal cord

4) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC2845559 Disease Relevance 1.75 Pain Relevance 0.46

Blots were probed with Iba-1 (1:1000), CB1 (1:1000), CB2 (1:1000) and p-p38 MAPK (1:1000).

Gene_expression (probed) of Iba-1

5) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC2845559 Disease Relevance 0.06 Pain Relevance 0.19

Western blotting confirmed lower levels of both Iba-1 and p-p38 MAPK protein expression in the dorsal spinal cord (Figure 8) of mice who received cannabidiol at diabetes onset.

Gene_expression (expression) of Iba-1 in spinal cord associated with diabetes mellitus and spinal cord

6) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC2845559 Disease Relevance 1.10 Pain Relevance 0.42

Despite transient improvement in neuropathic pain measures, diabetic mice receiving intranasal/intraperitoneal nabilone, WIN55212-2, or SR141716A had no differences noted for microglial densities (Table 3) and no visible changes in protein expression of Iba-1 or p-p38 MAPK within the dorsal spinal cord (Figure 11).

Gene_expression (expression) of Iba-1 in dorsal associated with diabetes mellitus, neuropathic pain and spinal cord

7) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC2845559 Disease Relevance 1.46 Pain Relevance 0.97

In contrast, Chlamydia-specific IgG Abs were not detected in vaginal secretions.

Neg (not) Gene_expression (detected) of Chlamydia-specific associated with chlamydia infection

8) Confidence 0.04 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.85 Pain Relevance 0.18

We can conclude that IBD patients have higher CXCL9, CXCL10, and CXCL11 levels and Mycobacteria-specific IgG1 and IgG2 Ab responses.

Gene_expression (levels) of Mycobacteria-specific associated with inflammatory bowel disease

9) Confidence 0.04 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.94 Pain Relevance 0.03

These results suggest that IBD patients have higher CXCL9, CXCL10, and CXCL11 levels and Mycobacteria-specific IgG1 and IgG2 Ab responses.

Gene_expression (levels) of Mycobacteria-specific associated with inflammatory bowel disease

10) Confidence 0.04 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 1.00 Pain Relevance 0.11

Chlamydia-specific T helper cell responses

Gene_expression (responses) of Chlamydia-specific associated with chlamydia infection

11) Confidence 0.04 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.26 Pain Relevance 0.03

CCL5 modulation of Chlamydia-specific humoral responses

Gene_expression (responses) of Chlamydia-specific associated with chlamydia infection

12) Confidence 0.04 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.67 Pain Relevance 0.06

These results suggest that CCL5 is required in part for optimal Chlamydia-specific IgA Ab responses during C. muridarum infection.

Gene_expression (responses) of Chlamydia-specific associated with chlamydia infection and infection

13) Confidence 0.04 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.86 Pain Relevance 0.24

These results suggest that CCL5 is required for optimal generation of Chlamydia-specific CD4+ T cells that proliferate after Ag recognition.

Gene_expression (generation) of Chlamydia-specific in T cells associated with chlamydia infection

14) Confidence 0.03 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.71 Pain Relevance 0.06

For example, chronic postnatal exposure to combination of OVA and ETS tended to reduce OVA-specific immunoglobulin production compared to OVA-alone exposure and showed no evident effects on pulmonary inflammation, although airway hyperresponsiveness was increased.

Gene_expression (production) of OVA-specific associated with nicotine addiction, inflammation and pneumonia

15) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2831838 Disease Relevance 1.71 Pain Relevance 0.15

In an "asthmatic mouse", chronic co-exposure to MS and OVA did neither aggravate airway inflammation, OVA-specific IgE production and remodelling, nor accelerate emphysema development [95].

Gene_expression (production) of OVA-specific associated with asthma, emphysema, nicotine addiction and inflammation

16) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2831838 Disease Relevance 2.01 Pain Relevance 0.30

However, in a BALB/c model examining the development of allergic inflammation, Moerloose et al [93] demonstrated that acute concurrent exposure to allergen (OVA) and MS enhances the allergic pulmonary inflammation, and augments OVA-specific IgE production and airway hyperresponsiveness [93].

Gene_expression (production) of OVA-specific associated with nicotine addiction, inflammation, hypersensitivity and pneumonia

17) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2831838 Disease Relevance 2.13 Pain Relevance 0.33

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