INT101302

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.56
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aif1) plasma membrane (Aif1) cytoskeleton (Aif1)
cytoplasm (Aif1)
Anatomy Link Frequency
Macrophage 2
spinal cord 2
microglia 2
frontal cortex 2
Aif1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 28 100.00 Very High Very High Very High
Spinal cord 57 99.60 Very High Very High Very High
cytokine 26 95.64 Very High Very High Very High
Sciatic nerve 8 91.64 High High
Dorsal horn 26 88.92 High High
chemokine 13 88.88 High High
Neuritis 1 86.76 High High
imagery 4 79.88 Quite High
Action potential 5 67.28 Quite High
Thalamus 7 65.84 Quite High
Disease Link Frequency Relevance Heat
Chlamydia Infection 67 100.00 Very High Very High Very High
INFLAMMATION 33 100.00 Very High Very High Very High
Urological Neuroanatomy 5 99.84 Very High Very High Very High
Diabetes Mellitus 154 99.44 Very High Very High Very High
Infection 25 99.16 Very High Very High Very High
Targeted Disruption 163 89.60 High High
Experimental Autoimmune Neuritis 1 87.72 High High
Bone Disease 12 79.52 Quite High
Hypersensitivity 14 59.64 Quite High
Hyperalgesia 19 55.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Staining of the frontal cortex showed increased IBA1 expression in the mutant versus wild type mice (Figure 7C,D).
Positive_regulation (increased) of Gene_expression (expression) of IBA1 in frontal cortex associated with urological neuroanatomy
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.56 Pain Relevance 0
We used quantitative image analysis of immunoreactivity for Iba1, the expression of which is upregulated following activation of microglia, as a measure of cell activity.
Positive_regulation (upregulated) of Gene_expression (expression) of Iba1 in microglia
2) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0 Pain Relevance 0.29
Iba-1 protein expression increased over time in diabetic spinal cord specimens (Figure 3) as compared to non-diabetic specimens.
Positive_regulation (increased) of Gene_expression (expression) of Iba-1 in spinal cord associated with diabetes mellitus and spinal cord
3) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2845559 Disease Relevance 1.76 Pain Relevance 0.46
Macrophage-restricted and interferon gamma-inducible expression of the allograft inflammatory factor-1 gene requires Pu.1.
Positive_regulation (requires) of Gene_expression (expression) of allograft inflammatory factor-1 gene in Macrophage associated with inflammation
4) Confidence 0.14 Published 2002 Journal J. Biol. Chem. Section Title Doc Link 11861656 Disease Relevance 0.38 Pain Relevance 0.23
These results suggest that CCL5 is required in part for optimal Chlamydia-specific IgA Ab responses during C. muridarum infection.
Positive_regulation (required) of Gene_expression (responses) of Chlamydia-specific associated with chlamydia infection and infection
5) Confidence 0.03 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.86 Pain Relevance 0.24

General Comments

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