INT10131

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Context Info
Confidence 0.76
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 53
Total Number 56
Disease Relevance 35.57
Pain Relevance 6.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinf1) extracellular region (Serpinf1)
Anatomy Link Frequency
retina 12
optic nerve 9
epithelium 5
eyes 3
neurons 2
Serpinf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 24 99.56 Very High Very High Very High
Inflammation 800 98.20 Very High Very High Very High
Angina 5 96.84 Very High Very High Very High
ischemia 126 94.24 High High
cytokine 98 90.44 High High
withdrawal 42 88.64 High High
Glutamate 84 87.40 High High
Inflammatory marker 42 86.80 High High
fibrosis 39 86.56 High High
peripheral neuropathy 3 86.32 High High
Disease Link Frequency Relevance Heat
Aging 42 99.84 Very High Very High Very High
Peripheral Neuropathy 9 99.84 Very High Very High Very High
Diabetic Retinopathy 126 99.64 Very High Very High Very High
Pain 24 99.56 Very High Very High Very High
Ganglion Cysts 378 99.32 Very High Very High Very High
Glaucoma 1558 99.26 Very High Very High Very High
Hypoxia 46 98.80 Very High Very High Very High
Corneal Neovascularization 226 98.64 Very High Very High Very High
Wound Healing 12 98.52 Very High Very High Very High
INFLAMMATION 892 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In DBA/2J mice, semi-quantitative RT–PCR revealed significantly decreased retinal PEDF gene expression with age (Figure 2A,B).
Gene_expression (expression) of PEDF gene
1) Confidence 0.76 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.39 Pain Relevance 0
In situ expression of GFP can be observed from cross-section or whole-mount techniques, whereas the expression of PEDF is detected using western blot.
Gene_expression (expression) of PEDF
2) Confidence 0.76 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.30 Pain Relevance 0
The long-term effect of PEDF gene transfer on RGC survival was also examined.
Gene_expression (transfer) of PEDF gene
3) Confidence 0.76 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.07 Pain Relevance 0
Ocular PEDF gene transfection in DBA/2J mice leads to increased intraocular PEDF expression, improved retinal ganglion cell survival, and better vision
Gene_expression (transfection) of PEDF gene in retinal ganglion cell associated with ganglion cysts
4) Confidence 0.76 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.33 Pain Relevance 0
Preparation and intravitreous delivery of adeno-associated virus expressing human PEDF
Gene_expression (expressing) of PEDF
5) Confidence 0.76 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.08 Pain Relevance 0.03
Moreover, downregulation of PEDF expression by siRNA treatment of retinal Müller cells resulted in significantly increased TNF expression [10,58].
Gene_expression (expression) of PEDF
6) Confidence 0.76 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.98 Pain Relevance 0.21
We also showed age dependent decreases in PEDF gene expression and protein in the iris/ciliary body and aqueous humor, respectively.
Gene_expression (expression) of PEDF gene in ciliary body
7) Confidence 0.76 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.54 Pain Relevance 0.12
We demonstrate that endogenous PEDF expression in retina and optic nerve of DBA/2J mice declines with age, while PEDF transfection maintains RGC viability, inhibits TNF and IL-18 upregulation, and reduces GFAP expression.
Gene_expression (expression) of PEDF in optic nerve
8) Confidence 0.76 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.36 Pain Relevance 0.24
Ocular PEDF gene transfection in DBA/2J mice leads to increased intraocular PEDF expression, improved retinal ganglion cell survival, and better vision
Gene_expression (expression) of PEDF in retinal ganglion cell associated with ganglion cysts
9) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.32 Pain Relevance 0
Adeno-associated virus expressing human PEDF (AAV-PEDF) has been used to protect neurons in animal models [27-29].
Gene_expression (expressing) of PEDF in neurons
10) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.09 Pain Relevance 0.08
Adeno-associated virus expressing human PEDF (AAV-PEDF) has been used to protect neurons in animal models [27-29].
Gene_expression (expressing) of AAV-PEDF in neurons
11) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.09 Pain Relevance 0.08
We demonstrate that endogenous PEDF expression in retina and optic nerve of DBA/2J mice declines with age, while PEDF transfection maintains RGC viability, inhibits TNF and IL-18 upregulation, and reduces GFAP expression.
Gene_expression (transfection) of PEDF in optic nerve
12) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.32 Pain Relevance 0.21
Transfection of AAV-PEDF resulted in a significant increase in PEDF protein level in retina from DBA/2J mice at 11 months of age (Figure 7C).
Gene_expression (Transfection) of AAV-PEDF in retina
13) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.23 Pain Relevance 0
It has also been suggested that the lower levels of PEDF in eyes with neuroretinal dystrophy may be related to the loss of the retinal ganglion or pigment epithelial cells that synthesize PEDF [22].
Gene_expression (synthesize) of PEDF in eyes associated with ganglion cysts
14) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.41 Pain Relevance 0
Our data suggest that PEDF may be involved in the pathogenesis of glaucoma in this mouse model, that decreased PEDF levels in aging eyes may contribute to subclinical inflammation in glaucoma, and that the protective effect of PEDF on glaucoma in DBA/2J mice may be mediated, at least in part, by its anti-inflammatory activity.
Gene_expression (levels) of PEDF in eyes associated with aging, inflammation and glaucoma
15) Confidence 0.66 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.27 Pain Relevance 0.19
Vitreous levels of PEDF were significantly decreased in proliferative diabetic retinopathy, suggesting that reduced PEDF in the retina may contribute to the pathogenesis of diabetic retinopathy, perhaps by augmentation of retinal inflammation [10,11].
Gene_expression (reduced) of PEDF in retina associated with inflammation and diabetic retinopathy
16) Confidence 0.66 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.37 Pain Relevance 0.26
First, PEDF protein levels in the retina and optic nerve of DBA/2J mice decrease significantly with age in comparison to C57BL/6J (control) mice.
Gene_expression (levels) of PEDF protein in optic nerve
17) Confidence 0.66 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.91 Pain Relevance 0.05
PEDF gene expression decreased in both the treated and untreated mice.
Gene_expression (expression) of PEDF gene
18) Confidence 0.61 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2779062 Disease Relevance 0.33 Pain Relevance 0.03
In the treated mice, the expression of PEDF decreased early and then increased progressively until day 14.
Gene_expression (expression) of PEDF
19) Confidence 0.61 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779062 Disease Relevance 0.37 Pain Relevance 0
At 6 months of age, decreased PEDF expression in the RGC layer with residual staining in the RPE layer of DBA/2J mice (Figure 3B) was detected when compared with the age-matched C57BL/6J controls (Figure 3C).


Gene_expression (expression) of PEDF
20) Confidence 0.59 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.43 Pain Relevance 0.08

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