INT10132

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Context Info
Confidence 0.58
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 11.72
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinf1) extracellular region (Serpinf1)
Anatomy Link Frequency
epithelium 4
eyes 2
retina 2
Plasma 1
vitreous humor 1
Serpinf1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 99.84 Very High Very High Very High
Pain 16 99.22 Very High Very High Very High
Inflammation 173 99.16 Very High Very High Very High
ischemia 26 94.40 High High
withdrawal 8 92.20 High High
Glutamate 16 90.96 High High
cytokine 21 90.24 High High
peripheral neuropathy 2 85.64 High High
Angina 5 50.00 Quite Low
Kinase C 1 47.64 Quite Low
Disease Link Frequency Relevance Heat
Diabetic Retinopathy 24 99.84 Very High Very High Very High
Aging 8 99.56 Very High Very High Very High
Glaucoma 297 99.48 Very High Very High Very High
Diabetes Mellitus 17 99.28 Very High Very High Very High
Pain 16 99.22 Very High Very High Very High
INFLAMMATION 196 99.16 Very High Very High Very High
Coronary Artery Disease 1 97.92 Very High Very High Very High
Cancer 25 97.68 Very High Very High Very High
Necrosis 16 97.20 Very High Very High Very High
Retina Disease 20 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PEDF levels in vitreous humor are decreased in patients with diabetes and proliferative retinopathy [57].
Negative_regulation (decreased) of PEDF in vitreous humor associated with diabetes mellitus and diabetic retinopathy
1) Confidence 0.58 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.03 Pain Relevance 0.16
PEDF levels in aqueous humor were significantly reduced in advanced glaucoma as compared to normal controls [8].
Negative_regulation (reduced) of PEDF associated with glaucoma
2) Confidence 0.58 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.06 Pain Relevance 0.21
The studies reported herein strongly suggest a role for PEDF in the maintenance of RGC in the DBA/2J mouse model of glaucoma, and add indirectly to the evidence for reduced PEDF as a possible pathogenic mechanism in human glaucoma.
Spec (possible) Negative_regulation (reduced) of PEDF associated with glaucoma
3) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.39 Pain Relevance 0.24
Our data suggest that PEDF may be involved in the pathogenesis of glaucoma in this mouse model, that decreased PEDF levels in aging eyes may contribute to subclinical inflammation in glaucoma, and that the protective effect of PEDF on glaucoma in DBA/2J mice may be mediated, at least in part, by its anti-inflammatory activity.
Negative_regulation (decreased) of PEDF in eyes associated with aging, inflammation and glaucoma
4) Confidence 0.42 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.27 Pain Relevance 0.19
PEDF protein levels in the retina and optic nerves of DBA/2J mice declined with age.
Negative_regulation (declined) of PEDF protein in optic nerves
5) Confidence 0.42 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2647972 Disease Relevance 0.83 Pain Relevance 0.10
Reduction in PEDF gene and protein expression with age in eyes of DBA/2J mice
Negative_regulation (Reduction) of PEDF gene in eyes
6) Confidence 0.37 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.41 Pain Relevance 0
Vitreous levels of PEDF were significantly decreased in proliferative diabetic retinopathy, suggesting that reduced PEDF in the retina may contribute to the pathogenesis of diabetic retinopathy, perhaps by augmentation of retinal inflammation [10,11].
Negative_regulation (decreased) of PEDF in retina associated with inflammation and diabetic retinopathy
7) Confidence 0.37 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.32 Pain Relevance 0.27
With bevacizumab treatment, PEDF levels decreased on day 2 (0.44 fold), followed by a 2-fold increase on days 8 and 10, and a 5.48-fold increase on day 14 (Table 4, Figure 6B).


Negative_regulation (decreased) of PEDF
8) Confidence 0.30 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779062 Disease Relevance 0.06 Pain Relevance 0.03
In NPN patients we found an expression level decrease of three pigment epithelium-derived factor (PEDF) protein isoforms.
Negative_regulation (decrease) of PEDF in epithelium associated with pain
9) Confidence 0.25 Published 2005 Journal Proteomics Section Abstract Doc Link 16196102 Disease Relevance 1.08 Pain Relevance 0.73
In NPN patients we found an expression level decrease of three pigment epithelium-derived factor (PEDF) protein isoforms.
Negative_regulation (decrease) of epithelium-derived factor in epithelium associated with pain
10) Confidence 0.21 Published 2005 Journal Proteomics Section Abstract Doc Link 16196102 Disease Relevance 1.08 Pain Relevance 0.73
PEDF protein levels in the retina and optic nerves of DBA/2J mice declined with age.
Negative_regulation (declined) of PEDF protein in retina
11) Confidence 0.14 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2647972 Disease Relevance 0.83 Pain Relevance 0.10
Several other mechanisms may also contribute to corneal avascularity, such as the angiostatic nature of corneal epithelial cells, low levels of pro-angiogenic matrix metalloproteinases (MMPs), several anti-angiogenic factors—including pigment epithelium-derived factor and tissue inhibitor of metalloproteinases—as well as the barrier function of limbal cells [33].
Negative_regulation (inhibitor) of epithelium-derived factor in epithelium associated with metalloproteinase
12) Confidence 0.14 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2913137 Disease Relevance 0.28 Pain Relevance 0.10
This results from an increase in proangiogenic factors such as VEGF or a decrease in antiangiogenic factors such as pigment epithelium-derived factor (PEDF).
Negative_regulation (decrease) of PEDF in epithelium
13) Confidence 0.13 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 0.87 Pain Relevance 0.27
METHODS AND RESULTS: Plasma levels of SDF-1alpha were significantly decreased in patients with stable (n=30) and unstable angina (n=30) compared with healthy control subjects (n=20), particularly in those with unstable disease.
Negative_regulation (decreased) of SDF in Plasma
14) Confidence 0.01 Published 2002 Journal Circulation Section Body Doc Link 12093767 Disease Relevance 0.19 Pain Relevance 0
Furthermore, the latter group exhibited an elevation of F VIII activity, alpha 2-macroglobulin activity, and alpha 1-antitrypsin concentration and a significant reduction of antiplasmin activity despite a normal alpha 2-antiplasmin concentration.
Negative_regulation (reduction) of antiplasmin
15) Confidence 0.00 Published 1992 Journal Am. J. Med. Section Body Doc Link 1466361 Disease Relevance 0 Pain Relevance 0

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