INT101323

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Context Info
Confidence 0.40
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Amt) methyltransferase activity (Amt) cytoplasm (Amt)
Amt (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 20 99.14 Very High Very High Very High
agonist 4 98.78 Very High Very High Very High
Cannabinoid 12 97.46 Very High Very High Very High
Endocannabinoid 8 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methylation of the amide group decreased the activity at VR1, AMT, and FAAH.
Negative_regulation (decreased) of AMT
1) Confidence 0.40 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861807 Disease Relevance 0 Pain Relevance 0.27
Novel arvanil derivatives prepared by N-methylation, replacement of the amide with urea and thiourea moieties, and manipulation of the vanillyl group were evaluated for their ability to bind/activate CB1 receptors, activate VR1 receptors, inhibit the AMT and fatty acid amide hydrolase (FAAH), and produce cannabimimetic effects in mice.
Negative_regulation (inhibit) of AMT
2) Confidence 0.33 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861807 Disease Relevance 0 Pain Relevance 0.29
Arvanil, a structural "hybrid" between the endogenous cannabinoid CB1 receptor ligand anandamide and capsaicin, is a potent agonist for the capsaicin receptor VR1 (vanilloid receptor type 1), inhibits the anandamide membrane transporter (AMT), and induces cannabimimetic responses in mice.
Negative_regulation (inhibits) of AMT associated with qutenza, cannabinoid and agonist
3) Confidence 0.29 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861807 Disease Relevance 0 Pain Relevance 0.33
On the aromatic ring, the substitution of the 3-methoxy group with a chlorine atom or the lack of the 4-hydroxy group decreased the activity on VR1 and AMT, but not the affinity for CB1 receptors, and increased the capability to inhibit FAAH.
Negative_regulation (decreased) of AMT
4) Confidence 0.29 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861807 Disease Relevance 0 Pain Relevance 0.25

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