INT101327

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Context Info
Confidence 0.25
First Reported 2002
Last Reported 2002
Negated 2
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Amt) signal transduction (Cnr1) methyltransferase activity (Amt)
aging (Cnr1) plasma membrane (Cnr1) cytoplasm (Amt)
Cnr1 (Mus musculus)
Amt (Mus musculus)
Pain Link Frequency Relevance Heat
Endocannabinoid 4 75.00 Quite High
qutenza 10 69.68 Quite High
agonist 2 68.96 Quite High
Cannabinoid 6 66.32 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The urea or thiourea analogs retained activity at VR1 and AMT but exhibited little affinity for CB1 receptors.
CB1 Neg (little) Binding (affinity) of AMT
1) Confidence 0.25 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861807 Disease Relevance 0 Pain Relevance 0.23
On the aromatic ring, the substitution of the 3-methoxy group with a chlorine atom or the lack of the 4-hydroxy group decreased the activity on VR1 and AMT, but not the affinity for CB1 receptors, and increased the capability to inhibit FAAH.
CB1 Neg (not) Binding (affinity) of AMT
2) Confidence 0.25 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861807 Disease Relevance 0 Pain Relevance 0.24

General Comments

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