INT10133

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 5.21
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F12) extracellular space (F12) extracellular region (F12)
Anatomy Link Frequency
blood 2
plasma 2
F12 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 11 99.92 Very High Very High Very High
Angina 15 97.92 Very High Very High Very High
Pain 10 93.96 High High
Inflammation 7 93.60 High High
bradykinin 1 89.44 High High
anesthesia 4 64.16 Quite High
agonist 1 57.12 Quite High
antagonist 1 56.08 Quite High
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 18 99.92 Very High Very High Very High
Targeted Disruption 6 99.00 Very High Very High Very High
Thrombosis 12 98.24 Very High Very High Very High
Sprains And Strains 1 98.00 Very High Very High Very High
Hematoma 74 97.46 Very High Very High Very High
Brain Hemorrhage 3 95.92 Very High Very High Very High
Contusions 1 95.04 Very High Very High Very High
Septic Shock 2 94.80 High High
Pain 6 93.96 High High
INFLAMMATION 4 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Characterization of factor XII Tenri, a rare CRM-negative factor XII deficiency.
Negative_regulation (deficiency) of factor XII
1) Confidence 0.49 Published 2004 Journal Ann. Clin. Lab. Sci. Section Title Doc Link 15228238 Disease Relevance 0.09 Pain Relevance 0.09
FXII deficiency has, however, not convincingly been shown to protect against arterial thrombosis in humans.
Negative_regulation (deficiency) of FXII associated with thrombosis
2) Confidence 0.43 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 17996217 Disease Relevance 0.67 Pain Relevance 0.14
Therefore, a complete evaluation of all these properties of FXII and FXIIa has to be considered when formulating a strategy for blocking FXII activation.
Negative_regulation (evaluation) of FXII
3) Confidence 0.43 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 17996217 Disease Relevance 0.58 Pain Relevance 0.18
Based on these experiments it has, therefore, been suggested, that blocking of FXII could be a unique target to prevent obstructive clot formation in arterial thrombosis without side effect of increased bleeding.
Negative_regulation (blocking) of FXII associated with cva and thrombosis
4) Confidence 0.43 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 17996217 Disease Relevance 0.55 Pain Relevance 0.05
Preoperative blood coagulation scan revealed prolonged activated partial thrombin time of 105.6 s (control, 30.3 s), and a decrease in factor XII level of 3% (normal; 70-120%).
Negative_regulation (decrease) of factor XII in blood
5) Confidence 0.42 Published 2001 Journal Masui Section Abstract Doc Link 11424474 Disease Relevance 0.18 Pain Relevance 0
[Anesthetic management of a patient with blood coagulation factor XII deficiency].
Negative_regulation (deficiency) of factor XII in blood
6) Confidence 0.42 Published 2001 Journal Masui Section Title Doc Link 11424474 Disease Relevance 0.23 Pain Relevance 0.06
Characterization of factor XII Tenri, a rare CRM-negative factor XII deficiency.
Negative_regulation (deficiency) of factor XII
7) Confidence 0.41 Published 2004 Journal Ann. Clin. Lab. Sci. Section Title Doc Link 15228238 Disease Relevance 0.09 Pain Relevance 0.09
Factor XII Tenri (Y34C), a rare cross-reacting material (CRM)-negative factor XII deficiency, was identified in a 71-yr-old Japanese woman with angina pectoris.
Negative_regulation (deficiency) of factor XII associated with angina
8) Confidence 0.41 Published 2004 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15228238 Disease Relevance 0.10 Pain Relevance 0.10
Extensive investigations did not reveal any abnormality apart from an elevated activated partial thromboplastin time as a result of factor XII deficiency.
Negative_regulation (deficiency) of factor XII
9) Confidence 0.16 Published 2004 Journal Australas. J. Dermatol. Section Abstract Doc Link 14961912 Disease Relevance 0.26 Pain Relevance 0.26
Mice deficient in tissue kallikrein, B1 and B2 receptors, some kinin-degrading enzymes, and factor XII followed, together with transgenic rat and mouse strains overexpressing tissue kallikrein, B1 and B2 receptors, and degrading enzymes.
Negative_regulation (deficient) of factor XII associated with targeted disruption and sprains and strains
10) Confidence 0.05 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16497143 Disease Relevance 0.42 Pain Relevance 0.16
DNA sequencing revealed no abnormality in 3 patients in the coding region of the gene encoding C1 inhibitor or in the 5' flanking regions of the genes encoding C1 inhibitor and factor XII.
Negative_regulation (inhibitor) of factor XII
11) Confidence 0.02 Published 2000 Journal J. Allergy Clin. Immunol. Section Body Doc Link 10984376 Disease Relevance 0 Pain Relevance 0
Levels of factor XII were reduced in 2 patients who had single factor assays performed, consistent with activation of the kallikrein-kinin system.
Negative_regulation (reduced) of factor XII
12) Confidence 0.01 Published 2000 Journal Clin. Infect. Dis. Section Abstract Doc Link 10880316 Disease Relevance 0.33 Pain Relevance 0.12
RESULTS: The AMI group showed a significant reduction in F XII activity, F XII activity-to-concentration ratio, and HMWK concentration.
Negative_regulation (reduction) of F XII
13) Confidence 0.01 Published 1992 Journal Am. J. Med. Section Body Doc Link 1466361 Disease Relevance 0 Pain Relevance 0
RESULTS: The AMI group showed a significant reduction in F XII activity, F XII activity-to-concentration ratio, and HMWK concentration.
Negative_regulation (reduction) of F XII
14) Confidence 0.01 Published 1992 Journal Am. J. Med. Section Body Doc Link 1466361 Disease Relevance 0 Pain Relevance 0
When compared to the range of normal plasma, the hematoma fluids demonstrated a marked reduction in factor II, V, VII, VIII, and X, moderate reduction of factors IX and XI, and slight reduction of factor XII.
Negative_regulation (reduction) of factor XII in plasma associated with hematoma
15) Confidence 0.01 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628130 Disease Relevance 0.86 Pain Relevance 0
Rather, there was a marked reduction in factor VIII, moderate reduction in factor IX and XI, and a slight reduction in factor XII.
Negative_regulation (reduction) of factor XII
16) Confidence 0.01 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628130 Disease Relevance 0.83 Pain Relevance 0
CONCLUSIONS: The observed reduction of the plasma F XII activity-to-antigen concentration ratio combined with a reduced HMWK concentration suggests intrinsic pathway activation, while the elevation of the D-dimer concentration indicates thrombin generation and fibrin formation and degradation in the AMI group.
Negative_regulation (reduction) of F XII in plasma
17) Confidence 0.01 Published 1992 Journal Am. J. Med. Section Body Doc Link 1466361 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox