INT101340
From wiki-pain
|
|
|
|
|
Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Ramelteon also is a synthetic analog of melatonin.29 It is a MT1 and MT2 receptor agonist drug currently approved in the United States, Europe, and elsewhere for the treatment of insomnia characterized by difficulty falling sleep.34 Unlike agomelatine, it does not bind to any serotonin receptors and has not been investigated as an antidepressant.24 Mirtazapine and some other antidepressant drugs have 5HT-2C receptor blocking effects.37 Many of the so-called atypical or second generation antipsychotic drugs also have 5HT-2C receptor blocking effects,37 and these drugs are efficacious as augmentation agents when used together with antidepressant drugs for treatment resistant depression.38 The pharmacology of agomelatine, with its combined effects at MT1, MT2, and 5HT-2C receptors, is therefore unique and distinct compared to other antidepressant drugs. | |||||||||||||||
| |||||||||||||||
|
Melatonin (MLT) is the main hormone released from the pineal gland and has proved to have physiological antitumor activity. | |||||||||||||||
| |||||||||||||||
|
We used an oral fast release melatonin at a dose of 3 mg/day for 4 and 8 weeks. | |||||||||||||||
| |||||||||||||||
|
This observation is in agreement with KlupiƱska et al [18] who found that in patients with GERD and recurrent duodenal ulcers, melatonin concentration was lower than in healthy subjects and concluded that high or relatively correct secretion of melatonin is sufficient to prevent peptic changes in esophageal and duodenal mucosa. | |||||||||||||||
| |||||||||||||||
|
The interests of gstroenterologists mainly focused on studies on melatonin nocturnal secretion. | |||||||||||||||
| |||||||||||||||
|
General Comments
This test has worked.